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TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response
author: Jiang D, Wei S, Chen F, Zhang Y, Li J.
Abstract: An efficient, accurate, and timely DNA damage response (DDR) is crucial for the maintenance of genome integrity. Here, we report that ten-eleven translocation dioxygenase (TET) 3-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in response to ATR-dependent DDR regulates DNA repair. ATR-dependent DDR leads to dynamic changes in 5hmC levels and TET3 enzymatic activity. We show that TET3 is an ATR kinase target that oxidizes DNA during ATR-dependent DNA damagerepair. Modulation of TET3 expression and activity affects DNA damage signaling and DNA repair and consequently cell death. Our results provide novel insight into ATR-mediated DDR, in which TET3-mediated DNA demethylation is crucial for efficient DNA repair and maintenance of genome stability
Contact the author: lijiali@mail.kiz.ac.cn
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PubYear: 2017
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Unit code: 152453
Publication name: EMBO reports.
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Paper source: ://embor.embopress.org/content/early/2017/03/21/embr.201643179
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