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何永捍  研究员
衰老调控与功能研究学科组
职  务: 衰老调控与功能研究学科组 负责人
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电子邮件: heyonghan@mail.kiz.ac.cn
通讯地址: 云南省昆明市盘龙区茨坝街道龙欣路17号 425室    650201
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  简  历

何永捍,博士,研究员,中国科学院昆明动物研究所“衰老调控与功能研究”学科组负责人。从事衰老及衰老相关疾病的功能学研究,已在Nature CommunicationsGenome ResearchAging CellJournal of Hematology & OncologyTheranostics等国际核心刊物上发表研究论文60余篇;作为核心发明人申请抗衰老和抗肿瘤美国专利3项;参编衰老研究国际著作《Senolytics in Disease, Ageing and Longevity》。

学习和研究经历

2020.10 - 至今      中国科学院昆明动物研究所,研究员

2018.06 - 2020.09   美国佛罗里达大学,博士后

2016.10 - 2018.05   美国阿肯色医科大学,博士后

2015.01 - 2016.09   中国科学院昆明动物研究所,副研究员

2013.01 - 2014.12  中国科学院昆明动物研究所,助理研究员

2011.09 - 2012.09   加拿大国家研究委员会(NRC),访问学者

2007.09 - 2012.12   哈尔滨医科大学,医学博士学位

2002.09 - 2007.07   哈尔滨医科大学,医学学士学位

  研究方向

衰老是一个极其复杂的生物学性状,是衰老相关疾病的重要危险因素。研究衰老调控机理、挖掘有效抗衰老策略对认识衰老的本质及衰老相关疾病的防治具有重大意义。基于云南得天独厚的动物资源,课题组重点开展的研究方向有:

1)衰老调控:利用多组学手段,从遗传、进化等角度解析动物和人体衰老的调控网络,识别衰老及独特生物学性状(如肿瘤抵抗、极端环境适应等)的调控因子;

2)衰老靶点:利用衰老生物模型(线虫、果蝇、小鼠或灵长类等),挖掘衰老及相关性状的干预靶点,制定有效的干预措施;

3)细胞衰老和小分子药物:细胞是组成机体的基本单位,细胞衰老是生物衰老的直接原因。我们利用模式生物及人体细胞的衰老体系研究针对衰老细胞的体内、外干预策略(如),为抗衰老、延长健康寿命提供理论和应用依据。

  承担科研项目

[1] 国家自然科学基金面上项目,81671404,长寿人群特异低表达基因-甲状腺素转运蛋白MCT10调控衰老的作用机制研究,50万,在研,主持

[2] 国家自然科学基金青年基金项目,81500670,热休克蛋白 70HSP-70)在肥胖发生中的作用和机制研究, 21.42万,结题,主持

[3] 国家重点基础研究发展计划(973计划)项目,2013CB530802,“内脏器官衰老与相关老年疾病防治的基础研究”子课题, 96.93万,结题,课题骨干

[4] 中国科学院A类战略性先导科技专项“泛第三极环境变化与绿色丝绸之路建设”项目子课题, 137.262万,在研,课题骨干

[5] 云南省应用基础研究计划重点项目,2017FA038,甲状腺素单羧酸转运蛋白10 影响衰老/寿命的作用及机制研究,50万,在研,主持

[6] 云南省应用基础研究计划面上项目,2013FB069,中国人群长寿相关DNA甲基化调控位点的筛查和功能研究,10万,结题,主持

[7] 中科院西部之光“西部博士”项目,20万,结题,主持

  专家类别
研究员
  社会任职
  获奖及荣誉

2020年 美国血液协会第61届学术年会研究报告成就奖

2016年 中国科学院青年创新促进会会员

2013年 黑龙江省高校科学技术一等奖

2013年 黑龙江省科技进步二等奖

  代表论著

 (#共同一作,*共同通讯)

[1] He YH#, Zhang X(uan)#, Chang JH#, Kim H#, Zhang PY, Wang YY, Khan Sajid, Liu XG, Zhang X(in), Lv DW, Li W, Thummuri Dinesh, Yuan YX, Elisseeff Jennifer, Campisi Judith, Almeida Maria, Song L, Zheng GR*, Zhou DH*. Using Proteolysis-Targeting Chimera Technology to Reduce Navitoclax Platelet Toxicity and Improve Its Senolytic Activity. Nature Communications. 2020;11(1):1996

[2] He YH, Koch R, Budamagunta V, Zhang PY, Zhang X(uan), Khan S, Thummuri D, Ortiz Y. T, Zhang X(in), Lv DW, Wiegand J. S, Li W, Palmer A. C, Zheng GR, Weinstock D. M*, Zhou DH*. DT2216–a Bcl-xL specific degrader is highly active against Bcl-xL-dependent T-cell lymphomas. Journal of Hematology & Oncology. 2020;13(1):95

[3] He YH, Wen Li, Lv DW, Zhang Xin, Zhang X, Campisi Judith, Zheng GR, Zhou DH*. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging Cell. 2020; 19(3):e13117

[4] He YH#, Khan S#, Huo ZG, Lv DW, Zhang X, Liu XG, Yuan YX, Hromas R, Xu MJ, Zheng GR, Zhou DH. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. Journal of Hematology & Oncology. 2020;13(1):103

[5] He YH, Zheng GR, Zhou DH. Senolytic Drug Development. In: Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity. Springer, Cham. 2020; 11. Doi: 10.1007/978-3-030-44903-2_1 (Book chapter)

[6] Khan S#, He YH# , Zhang X, Yuan YX, Pu SY, Kong QP, Zheng GR, Zhou DH*. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. Oncogene. 2020;39(26):4909-4924

[7] Zhang X#, He YH#, Zhang PY#, Budamagunta V, Lv DW, Thummuri D, Yang Y, Pei J, Yuan YX, Zhou DH*, Zheng GR*. Discovery of IAP-Recruiting BCL-XL PROTACs as Potent Degraders across Multiple Cancer Cell Lines. European Journal of Medicinal Chemistry. 2020;199:112397.

[8] Khan Sajid#, Zhang X#, Lv DW#, Zhang Q, He YH, Zhang PY, Yuan YX, Liu XG, Thummuri Dinesh, Wiegand Janet, Ferrando Adolfo, Hromas Robert, Konopleva Maria, Zheng GR*, Zhou DH*. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nature Medicine. 2019;25(12):1938-1947

[9] He YH, Thummuri D, Zheng GR, Okunieff P, Citrin DE, Vujaskovic Z, Zhou DH*. Cellular Senescence and Radiation-induced Pulmonary Fibrosis. Translational Research. 2019;209:14-21

[10] Yu Q, Pu SY, Wu H, Chen XQ, Jiang JJ, Gu KS, He YH*, Kong QP*. TICRR Contributes to Tumorigenesis through Accelerating DNA Replication in Cancers. Front Oncol. 2019;9:516

[11] Li W#, Qin L#, Feng RN, Hu GR, Sun H, He YH*, RP Zhang*. Emerging senolytic agents derived from natural products. Mechanisms of Ageing and Development. 2019;181:1-6

[12] Xiao FH#, Chen XQ#, Yu Q#, Ye YS#, Liu YW, Yan DJ, Yang LQ, Chen GJ, Lin R, Yang LP, Liao XP, Zhang W, Zhang W, Wang XF, Zhou JM*, Cai WW*, He YH*, Kong QP*. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research. 2018;28(11):1601-1610

[13] He YH*, Li Wen, Hu GR, Kong QP. Bioactivities of EF24, a novel curcumin analog: A review. Frontiers in Oncology. Front Oncol. 2018;11(8):614

[14] Xiao FH, Chen XQ, He YH, Kong QP*. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. Clinical Epigenetics. 2018;10(1):133

[15] Li QG#, He YH#, Wu H#, Yang CP, Pu SY, Fan SQ, Jiang LP, Shen QS, Wang XX, Chen XQ, Yu Q, Li Y, Sun C, Wang XT, Zhou JM, Li HP, Chen YB*, Kong QP*. A normalization-free and nonparametric method sharpens pan-cancer expression analysis. Theranostics. 2017;7(11):2888-2899

[16] Pu SY#, Yu Q#, Wu H, Jiang JJ, Chen XQ, He YH*, Kong QP*. ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers. Oncotarget. 2017;8(26):42116-42124

[17] He YH#, Chen XQ#, Yan DJ, Xiao FH, Lin R, Liao XP, Liu YW, Pu SY, Yu Q, Sun HP, Jiang JJ, Cai WW*, Kong QP*. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. Neurobiology of Aging. 2016;47:218.e11-218.e18

[18] He YH, Pu SY, Xiao FH, Chen XQ, Yan DJ, Liu YW, Lin R, Liao XP, Yu Q, Yang LQ, Yang XL, Ge MX, Li Y, Jiang JJ, Cai WW*, Kong QP*. Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families. Scientific Reports. 2016;25;6:21962

[19] He YH#, Lu X#, Tian JY, DJ Yan, Li YC, Lin R, Perry B, Chen XQ, Yu Q, Cai WW*, Kong QP*. Mitochondrial DNA contributes equally to female and male longevity in Chinese centenarians. Experimental Gerontology. 2016;83:94-96

[20] Xiao FH, Kong QP, Perry B, He YH*. Progress on the role of DNA methylation in aging and longevity. Briefings in Functional Genomics. 2016;15(6):454-459

[21] Han LY, Liu YF, Duan SW, Perry B, Li W*, He YH*. DNA methylation and hypertension: emerging evidence and challenges. Briefings in Functional Genomics. 2016;15(6):460-469

[22] Jiang JJ, Cheng LH, Wu H, He YH*, Kong QP*. Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance. Epigenetics & Chromatin. 2016;9:51

[23] He YH, Chen XQ, Yan DJ, Xiao FH, Liu YW, Lin R, Liao XP, Cai WW*, Kong QP*. Thyroid function decreases with age and may contribute to longevity in Chinese centenarians’ families. J Am Geriatr Soc. 2015;63(7) 1474-1476

[24] Yu Q, Sun HP, Chen WQ, Chen XQ, Xu Y*, He YH*, Kong QP*. Sex-specific association of rs4746172 of VCL gene with hypertension in two Chinese Han populations. Scientific Reports. 2015;5:15245

[25] Xiao FH#, He YH#, Li QG, Wu H, Luo LH, Kong QP*. A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. PLoS One. 2015;10(3):e0120388

[26] He YH, Lu X, Wu H, Cai WW*, Yang LQ, Sun HP, Kong QP*. MtDNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. Neurobiology of Aging. 2014;35(7):1779.e1-1779.e14

[27] He YH, Zhang YX, Yang LQ, Liao XP, Cai WW*, Kong QP*. Assessment of the health status of centenarians in the South of China: A cross-sectional study. J Am Geriatr Soc. 2014;62(7):1402-1404

[28] He YH, Lu X, Yang LQ, Xu LY, Kong QP*. Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians. Aging-US. 2014;6(11):944-56

[29] He YH, Kong WL, Wang G, Zhao Y, Bi MX, Na LX, Wang MQ, Perry B, Li Y*. The calcium-sensing receptor R990G polymorphism is associated with increased risk of hypertriglyceridemia in obese Chinese. Gene. 2014;533:67-71

[30] He YH, Li W, Li Y, Zhang SC, Wang YW*, Sun CH*. Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. PLoS One. 2014;9 (10): e110711

[31] He YH, Lu X, Bi MX, Yang LQ, Xu LY, Kong QP*. The reduction of vascular disease risk mutations contributes to longevity in Chinese. Meta Gene. 2014;2:761-768.

[32] He YH, Li Y, Zhang SC, Perry B, Zhao TT, Wang YW*, Sun CH*. Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2013;436: 169-174

[33] He YH, Perry B, Bi MX, Sun H, Zhao TT, Li Y*, Sun CH*. Allosteric regulation of the calcium-sensing receptor in obese individuals. Int J Mol Med. 2013;32:511-518

[34] He YH, Li Y, Zhao TT, Wang YW*, Sun CH*. Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. PLoS One. 2013;8: 8(7):e70135

[35] He YH, Han LY, Li W, Shu X, Zhao C, Bi MX, Li Y*, Sun CH*. Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in healthy individuals: a meta-analysis. Gene. 2012;491:110-115

[36] He YH, He Y, Liao XL, Niu YC, Wang G, Zhao C, Wang L, Tian MJ, Li Y*, Sun CH*. The calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPARgamma pathway. Molecular and Cellular Biochemistry. 2012;361:321-328

[37] He YH, Song Y, Liao XL, Wang L, Li G, Alima, Li Y*, Sun CH*. The calcium-sensing receptor affects fat accumulation via effects on antilipolytic pathways in adipose tissue of rats fed low-calcium diets. Journal of Nutrition. 2011;141(11):1938-46

[38] He YH, Li ST, Wang YY, Wang G, He Y, Liao XL, Sun CH*, Li Y*. Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. Journal of Nutritional Biochemistry. 2011;23:1238-1244

[39] He YH, Zhang HQ, Teng JH, Huang LN, Li Y*, Sun CH*. Involvement of calcium-sensing receptor in inhibition of lipolysis through intracellular cAMP and calcium pathways in human adipocytes. Biochem Biophys Res Commun. 2011;404:393-399  

  研究团队

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