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研究队伍 -- 非人灵长类感觉、运动及其整合研究组
  胡新天    研究员
职  务:
学  历: 博士
电  话: +86 871 65197002
传  真: +86 871 65193083
电子邮件: xthu@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号 中国科学院昆明动物研究所    650223
其他主页: http://159.226.149.45/other/labhuxintian/
 
  简  历

胡新天,研究员,博士生导师,中国科学院百人计划获得者。男,1964年12月18日生。 1994-2000年美国普林斯顿大学神经生物学博士,2000-2005年贝勒医学院博士后。2005年回国建立中国科学院昆明动物所非人灵长类运动,感觉及其整合实验室。2007年获中国科学院百人计划资助。2014年,被聘为中国科学院脑卓越中心核心骨干。 

  研究方向

胡新天实验室长期从事非人灵长类神经生物学的研究,学科组主要从事脑疾病相关方面的研究;重点关注老年痴呆症、帕金森病猕猴模型的建立,学习记忆、老年痴呆及帕金森病相关神经回路的研究。目前已建立了一种人类早期逆境(Feng et al,PNAS 2011),两种新型帕金森氏病,两种种新型老年痴呆(Yang et al,Journal of Alzheimer’s disease,2014)和三种抑郁症的新型猕猴模型。另外,他还:1)首次报道了猕猴脑内每个运动命令在单个运动前神经元上得到了高度精确的表达(Hu et al,PNAS 2007,第一和通讯作者),2)参与发现了猕猴大脑前额叶运动前区存在一种全新的空间信息编码系统,这一系统对于脑内运动编程有重要意义(Graziano et al, Science 1997);3)成功研制了国内外第一台具有实用价值的电刺激噪声干扰压制器,在首次将电刺激和单位放电记录这两项重要的神经电生理研究技术有机的结合起来,形成了一个研究脑内回路的有力工具,是神经电生理研究方法学上的一个重要突破(专利号: ZL2007 1 0031057.8)

  承担科研项目
  专家类别
百人计划;省、部级有突出贡献专家;研究员
  社会任职
  获奖及荣誉

1. 谭恒;王毅;胡新天;马原野。多功能可调猴椅。中国专利,授权时间(20091216日)(申请号: 2008 1 0027194.9)专利号:ZL2008 1 0027194.9 

2胡新天;马原野,李燕娇,杨美凤。模拟老年痴呆病变的非人灵长类动物模型的建立方法。中国专利,授权时间(2010120日)专利号:ZL 201010039183.X. 

3. 胡新天;马原野。一种电刺激噪声消除仪。中国专利,授权时间(20101124日)专利号: ZL2007 1 0031057.8 

4. 杨上川;胡新天;王正波;王文超;马原野。脑微量组织取样器。中国专利,授权时间(20131016日)专利号:ZL 201210110829.8 

5.杨上川;吴晶;胡英周;马原野;胡新天。中国专利,深部硬脑膜穿孔装置。中国专利,授权时间(2014122日)专利号:ZL 201210102811.3 

  代表论著

  1.   Li H, Lei X, Yan T, Li H, Huang B, Li L, Xu L, Liu L, Chen N, Lü L, Ma Y, Xu L, Li J, Wang Z, Zhang B, Hu X. The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys. Sci Rep. 2015 Jul 29;5:12178. doi: 10.1038/srep12178     

  2.   Qin D, Chu X, Feng X, Li Z, Yang S, Lü L, Yang Q, Pan L, Yin Y, Li J, Xu L, Chen L, Hu X. The first observation of seasonal affective disorder symptoms in rhesus macaque. Behav Brain Res. 2015 Jul 8. pii: S0166-4328(15)30082-6. doi: 10.1016/j.bbr.2015.07.005. [Epub ahead of print]     

  3.   He-Qun Liu,    Jing-Kuan Wei,      Bo Li,   Ming-Shan Wang, Rui-Qi Wu,   Joshua D. Rizak,  Li Zhong, Lu Wang,     Fu-Qiang Xu,  Yong-Yi Shen,     Xin-Tian Hu & Ya-Ping Zhang. Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological methods. Sci Rep. 2015 Jun 23;5:11531. doi: 10.1038/srep11531.     

  4.   Qin D, Rizak J, Chu X, Li Z, Yang S, Lü L, Yang L, Yang Q, Yang B, Pan L, Yin Y, Chen L, Feng X, Hu X. A spontaneous depressive pattern in adult female rhesus macaques. Sci Rep. 2015 Jun 10;5:11267. doi: 10.1038/srep11267.     

  5.   Lei X, Huang B, Li H, Jiang H, Hu X, Zhang B., Drift in centrality of different brain regions in an anatomical neural network with Parkinson’s disease: A view from complex network analysis. Neuroscience. 2015 Jul 23;299:107-24. doi: 10.1016/j.neuroscience.2015.04.056. Epub 2015 Apr 30.     

  6.   Li H, Lei X, Huang B, Rizak JD, Yang L, Yang S, Wu J, Lü L, Wang J, Yan T, Li H, Wang Z, Hu Y, Le W, Deng X, Li J, Xu L, Zhang B, Hu X. A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections. J Neurosci Methods. 2015 May 20. pii: S0165-0270(15)00181-8. doi: 10.1016/j.jneumeth.2015.05.008. [Epub ahead of print]     

  7.   Wei P, Liu N, Zhang Z, Liu X, Tang Y, He X, Wu B, Zhou Z, Liu Y, Li J, Zhang Y, Zhou X, Xu L, Chen L, Bi G, Hu X, Xu F, Wang L. Processing of visually evoked innate fear by a non-canonical thalamic pathway. Nat Commun. 2015 Apr 9;6:6756. doi: 10.1038/ncomms7756.     

  8.   Dongdong Qin; Joshua Rizak; Xiaoli Feng; Shangchuan Yang; Lichuan Yang; Xiaona Fan; Longbao Lü; Lin Chen; Xintian Hu. Cortisol responses to chronic stress in adult macaques: moderation by a polymorphism in the serotonin transporter gene. Behavioural Brain Research. 2014 Oct 13;278C:280-285.     

  9.   Rizak, JD., Ma, YY., Hu, XT. Is formaldehyde the missing link in AD pathology? The differential aggregation of Amyloid-beta with APOE isoforms in vitro. Current Alzheimer Research. Curr Alzheimer Res. 2014;11(5):461-8.     

  10.  Meifeng Yang, Jing Lu, Junye Miao, Joshua Rizak, Jianzhen Yang, Rongwei Zhai, Jun Zhou, Jiagui Qu, Jianhong Wang, Yuanye Ma, Xintian Hu *, Rongqiao He *. 2004, Alzheimer’s Disease and Methanol Toxicity (Pt.1): Chronic methanol feeding led to memory impairments, tau hyperphosphorylation in mice. Journal of Alzheimer’s disease. J Alzheimers Dis. 2014;41(4):1117-29     

  11. Meifeng Yang, Junye Miao, Joshua Rizak, Rongwei Zhai, Zhengbo Wang, Tanzeel Huma Anwar, Ting Li, Na Zheng, Shihao Wu, Yingwei Zheng, Xiaona Fan, Jianzhen Yang, Jianhong Wang, Yuanye Ma, Longbao Lü, Rongqiao He *, Xintian Hu *.  Alzheimer’s Disease and Methanol Toxicity (Pt.2): Lessons from four rhesus macaques (macaca mulatta) chronically fed methanol. J Alzheimers Dis. 2014;41(4):1131-47     

  12.  Yan T, Rizak JD, Yang S, Li H, Huang B, Ma Y, Hu X. Acute morphine treatments alleviate tremor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. PLoS One. 2014 Feb 10;9(2):e88404. doi: 10.1371/journal.pone.0088404. eCollection 2014.   

  13. Wu J, Wang W, Rizak JD, Wang Z, Wang J, Feng X, Dong J, Li L, Liu L, Xu L, Yang S, Hu X. A new method for piercing the tentorium cerebelli for implanting fragile electrodes into the brain stem in the rhesus monkey (Macaca mulatta). J Neurophysiol. 2014 Mar;111(5):1027-32.     

  14. Hu YZ, Jiang HH, Liu CR, Wang JH, Yu CY, Carlson S, Saarinen VM, Rizak J, Tian XG, Tan H, Chen ZY, Ma YY, Hu XT. What interests them in the pictures? -- The difference in eye tracking between rhesus monkeys and humans. Neuroscience Bulletin, 2013   

  15. Xintian Hu, Bing Su, and Weizhi Ji*Nonhuman Primates: Important Animal Models for Regenerative MedicineScience Supplement J. (April 27, 2012):_PF032712-DT     

  16.  Ma Y, Hu X, Wilson FA. The egocentric spatial reference frame used in dorsal-lateral prefrontal working memory in primates. Neurosci Biobehav Rev. 2012 Jan;36(1):26-33.【引用9次】     

  17.  Feng XL, Wang LN, Yang SC, Qin DD, Wang JH, Li CL, Lv LB, Ma YY, Hu XT. Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys. PNAS, 2011, 23; 108(34): 14312-7. 【引用28次】     

  18.  Wu J, Wang WC, Li L, Liu L, Wang GM, Tan HG, Jiang HH, Wang JH, Ma YY, Hu XT. A new MRI approach for accurately implanting microelectrodes into deep brain structures of the rhesus monkey (Macaca mulatta). Journal of Neuroscience Methods, 2010, 193: 203–209.【引用6次】     

  19.  Gu C, Li P, Hu B, Ouyang X, Fu J, Gao J, Song Z, Han L, Ma Y, Tian S, Hu X. Chronic Morphine Selectively Impairs Cued Fear Extinction in Rats: Implications for Anxiety Disorders Associated with Opiate Use. Neuropsychopharmacology. 2008, 33:666-673.     

  20.  Hu X*, Jiang H, Gu C, Li C, Sparks DL*. Reliability of oculomotor command signals carried by individual neurons. Proc Natl Acad Sci U S A. 2007, May 8;104(19):8137-42.      

  21.  Sparks DL, Hu X. Saccade initiation and the reliability of motor signals involved in the generation of saccadic eye movements. Novartis Found Symp. 2006;270:75-88; discussion 88-91, 108-13.     

  22.  Graziano MS, Alisharan SE, Hu X, Gross CG. The clothing effect: tactile neurons in the precentral gyrus do not respond to the touch of the familiar primate chair.Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11930-3..     

  23.  Graziano, M. S. A., X. T. Hu & C. G. Gross. 1997 CODING THE LOCATION OF OBJECTS IN THE DARK. Science. 277:239-242.   

  研究团队