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王树  研究员
离子通道药物研发学科组
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电子邮件: wangshu@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号 中国科学院昆明动物研究所    650223
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  简  历

2002-2008年中国科学技术大学生物物理和神经生物学系理学博士;2008-2012年康奈尔大学生物医学系博士后;2012-2017年中国科学院昆明动物研究所副研究员;2017-至今研究员。在NaturePNASJBCEMBO系列期刊发表SCI研究论文20余篇。

  研究方向

外周感觉神经系统参与和调节生物体的众多重要生理功能和相关疾病的发生发展,如疼痛、瘙痒和炎症等,但是其背后的分子、细胞和神经机制很大程度上并不清楚,阻碍了相关疾病的治疗和药物研发。通过建立疼痛、瘙痒和炎性疾病等动物模型,使用分子生物学、电生理记录、原代神经元培养及活细胞荧光成像、转录组和蛋白质组分析技术以及动物行为学分析,去解析外周神经系统相关疾病的分子机制,寻找疾病治疗的新靶点,在并在此基础上进行活性分子的筛选和药物研发。

  承担科研项目

中国科学院西部之光重点项目    30 

国家自然科学基金青年项目          23 

云南省应用基础研究计划面上项目    10 

中国科学院重点部署项目子课题      236

中国科学院青年创新促进会人才项目  50

  专家类别
特聘青年研究员
  社会任职
  获奖及荣誉
  代表论著

1.       Shu Wang* Dan Zhang, Jinsheng Hu, Qi Jia, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang*Jianru Xiao*. A clinical and mechanistic study of topical borneol-induced analgesia. EMBO molecular medicine 2017 Apr 10. (Impact factor 9.547) *第一兼通讯作者

2.       Deyuan Su, Yin Nian, Fenglei Zhang, Jinsheng Hu, Jianmin Cui, Ming Zhou, Jian Yang*, Shu Wang*. Thiazolidine reacts with thioreactive biomolecules. Free Radical Biology & Medicine 2017 Mar;104:272-279 (Impact factor 5.784)  *通讯作者

3.       Minghui Li, Wei K Zhang, Nicole M Benvin, Xiaoyuan Zhou, Deyuan Su, Huan Li, Shu Wang, Ioannis E Michailidis, Liang Tong, Xueming Li & Jian Yang. Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel. Nature Structural & Molecular Biology  2017 Mar;24(3):205-213. (Impact factor 13.338)

4.       Minghui Li#, Xiaoyuan Zhou#, Shu Wang#, IoannisMichailidis, Ye Gong, Deyuan Su, Huan Li, Xueming Li & Jian Yang. Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature 2017 Feb 2;542(7639):60-65. (Impact factor 38.138)  #共同第一作者

5.       Deyuan Su, Hong Zhao, Jinsheng Hu, Dan Tang, Jianmin Cui, Ming Zhou, Jian Yang*, Shu Wang*. TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy. EMBO Reports 2016 Oct;17(10):1422-1430. (Impact factor 7.739) *通讯作者

6.       Shu Wang, Huai-hu Chuang. C-terminal Dimerization Activates the Nociceptive Transduction Channel Transient Receptor Potential Vanilloid 1. Journal of Biological Chemistry 2011 Nov 25; 286(47): 40601–40607. (Impact factor 4.773)

7.       Elaine Wang#, Hui Li#, Shu Wang#, Alexander Y Chuang, and Huai-huChuang.Induction of TRPV1 desensitization by a biased receptor agonist. Channels (Austin) 2011 Nov-Dec;5(6):464-7. (Impact factor 2.140)  #共同第一作者

8.       Ahmed, Shu Wang, Huai-Hu Chuang, and Robert Oswald. Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations. Journal of Biological Chemistry 2011 Oct 7;286(40):35257-66. (Impact factor 4.773)

9.       90. Hui Li#, Shu Wang#, Alexander Y. Chuang, Bruce E. Cohen, and Huai-hu Chuang. Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Proceedings of the National Academy of Sciences. 2011 May 17;108(20):8497-502 (Impact factor 9.423)  #共同第一作者

10.   Shu Wang, Kinning Poon, Robert Oswald, and Huai-hu Chuang.Distinct Modulations of Human Capsaicin Receptor by Protons and Magnesium through Different Domains. Journal of Biological Chemistry  2010 Apr 9; 285(15): 11547–11556. (Impact factor 5.328)

11.   Shu Wang, Tai-Ran Xing, Ming-Liang Tang, Wu Yong, Chen-Chen Li, Di-Yun Ruan. Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons. Naunyn-Schmiedeberg Archives of Pharmacology 2008 May;377(3):245-53. (Impact factor 2.830)

12.   Shu Wang, Pu Hu, Hui-Li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Effects of Cd2+ on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area. Toxicology Letters 2008 Feb 15;176(3):215-22. (Impact factor 3.249)

13.   Shu Wang, Yan Gu, Hui-Li Wang, Xin-Mei Li, Ming Wang, Li-Guang Sun, Di-Yun Ruan. Inhibitory effect of Cd2+ on glycine-induced chloride current in rat hippocampal neurons. Brain Research Bulletin 2006 May 31;69(6):680-6. (Impact factor 1.684)

14.   Hao Sun, Hui-Li Wang, Shu Wang*. d-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro. Neuroscience Letter 2007 Mar 1; 417(2): 118-22. (Impact factor 2.085)  *通讯作者

15.   Wu Yong, Min-Min Zhang, Shu Wang, Di-Yun Ruan. Effects of sodium valproate on synaptic transmission and neuronal excitability in rat hippocampus. Clinical and Experimental Pharmacology and Physiology 2009 Nov;36(11):1062-7. (Impact factor 1.936)

16.   Wu Yong, Tai-Ran Xing, Shu Wang, Liang Chen, Pu Hu, Chen-Chen Li, Hui-li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Protective Effects of Gastrodin on Lead-Induced Synaptic Plasticity Deficits in Rat Hippocampus. Planta Medica 2009 Aug;75(10):1112-7. (Impact factor 2.037)

17.   Hui-Li Wang, Xiang-Tao Chen, Bin Yang, Fang-Li Ma, Shu Wang, Ming-Liang Tang, Ming-Gao Hao, and Di-Yun Ruan. Case-control study of blood lead levels and attention deficit hyperactivity disorder in Chinese children. Environmental Health Perspectives 2008 Oct;116(10):1401-6. (Impact factor 6.123)

18.   Pu Hu, Lei Sun, Zhi-Qiang Zhu, Xiao-Wei Hou, Shu Wang, Shan-Shan Yu, Hui-Li Wang, Ping Zhang, Ming Wang, Li-Wen Niu, Mai-Kun Teng, Di-Yun Ruan. Crystal structure of Natratoxin, a novel snake secreted phospholipasesA2 neurotoxin from Najaatra Venom inhibiting A-type K+ currents. Proteins-Structure, Function, and Bioinformatics 2008 Aug;72(2):673-83. (Impact factor 3.419)

19.   Zhi-Dian Niu, Ju-Tao Chen, Shu Wang, Ming Wang, Xin-Mei Li and Di-Yun Ruan. Inhibition of delayed rectifier K+ currents by copper in acutely dissociated rat hippocampal CA1 neurons. Toxicology Letters 2006 Sep 10;165(3):289-96. (Impact factor 2.784)

20.   Hui-Li Wang, Xiang-Tao Chen, Le Luo, Zhi-Yi Lou, Shu Wang, Ju-Tao Chen, Ming Wang, Li-Guang Sun and Di-Yun Ruan. Reparatory effects of nicotine on NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 region of chronically lead-exposed rats. European Journal of Neuroscience  2006 Mar;23(5):1111-9. (Impact factor 3.709)

  研究团队

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