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分子进化与基因组多样性学科组
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学  历: 理学博士
电  话: +86 871 6852 6518
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电子邮件: wanggd@mail.kiz.ac.cn
通讯地址: 云南省昆明市茨坝青松路21号西南生物多样性实验室,中国科学院昆明动物研究所    650204
其他主页: https://wanggd.weebly.com/
  简  历

研究员,特聘青年研究员,2004年毕业于山东大学生命科学学院获学士学位,2010年于中国科学院昆明动物研究所获得动物学博士学位,随后留所工作。期间至中科院北京基因组研究所和牛津大学学术访问。近年来已在Nature GeneticsNature CommunicationsPNASCell ResearchMolecular Biology and EvolutionNucleic Acids Research等国际著名SCI期刊发表论文20余篇。受邀为Nature Communications, Molecular Biology and EvolutionPLoS GeneticsBMC Genomics等国际知名期刊审稿。

2017.01 至今      研究员,特聘青年科学家

2015.11 2016.03   牛津大学,访问学者

2014.01 2016.12   中国科学院昆明动物研究所,副研究员

2010.01 2011.12   中国科学院北京基因组研究所,访问学者

2010.07 2013.12   中国科学院昆明动物研究所,助理研究员

2004.09 2010.06   中国科学院昆明动物研究所,获博士学位

2000.09 2004.06   山东大学生命科学学院,获学士学位

  研究方向

主要从事群体基因组学和复杂性状进化和遗传机制研究,以家犬为主要研究对象。研究方向为:1)家犬的驯化历史和趋同进化;2)人工选择和自然选择的遗传机制;3)复杂性状产生和进化的遗传机制。

  承担科研项目

1. 中国科学院青年创新促进会会员,2015年。

2. 第十七批云南省中青年学术和技术带头人后备人才,2014HB0442014/10-2017/10

3. 国家自然科学基金重大研究计划集成项目,9153130012,家犬在人工选择下的微进化研究,2016/01-2018/12336万元,主持。

4. 国家重点基础研究发展计划(973计划),2013CB835202,家犬性状进化的遗传和基因组基础,2013/01-2017/08300万,课题负责人。

5. 国家自然科学基金重大研究计划培育项目,91231108,家犬在人工选择下的高原适应机制研究,2013/01-2015/1290万元,主持。
  专家类别
特聘青年研究员
  社会任职
  获奖及荣誉
  代表论著

#第一作者;*通讯作者)

1.         Bixia Tang, Qing Zhou, Lili Dong, Wulue Li, Xiangquan Zhang, Li Lan, Shuang Zhai, Jingfa Xiao, Zhang Zhang, Yiming Bao, Ya-Ping Zhang, Guo-Dong Wang#, Wenming Zhao: iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Research 10/2018;, DOI:10.1093/nar/gky1041

2.         Guo-Dong Wang, Xiu-Juan Shao, Bing Bai, Junlong Wang, Xiaobo Wang, Xue Cao, Yan-Hu Liu, Xuan Wang, Ting-Ting Yin, Shao-Jie Zhang, Yan Lu, Zechong Wang, Lu Wang, Wenming Zhao, Bing Zhang, Jue Ruan, and Ya-Ping Zhang: Structure variation during dog domestication: insight from grey wolf and dhole genomes. National Science Review 7/2018 nwy076, https://doi.org/10.1093/nsr/nwy076

3.         Shyam Gopalakrishnan, Mikkel-Holger S. Sinding, Jazmín Ramos-Madrigal, Jonas Niemann, Jose A. Samaniego Castruita, Filipe G. Vieira, Christian Car?e, Marc de Manuel Montero, Lukas Kuderna, Aitor Serres, Víctor Manuel González-Basallote, Yan-Hu Liu, Guo-Dong Wang, Tomas Marques-Bonet, Siavash Mirarab, Carlos Fernandes, Philippe Gaubert, Klaus-Peter Koepfli, Jane Budd, Eli Knispel Rueness, Mads Peter Heide-J?rgensen, Bent Petersen, Thomas Sicheritz-Ponten, Lutz Bachmann, ?ystein Wiig, Anders J. Hansen, M. Thomas P. Gilbert: Interspecific Gene Flow Shaped the Evolution of the Genus Canis. Current Biology 10/2018; 28(21)., DOI:10.1016/j.cub.2018.08.041

4.         Yalan Han, Bowen Li, Ting-Ting Yin, Cheng Xu, Rose Ombati, Lei Luo, Yujie Xia, Lizhen Xu, Jie Zheng, Yaping Zhang, Fan Yang, Guo-Dong Wang#, Shilong Yang, Ren Lai: Molecular mechanism of the tree shrew’s insensitivity to spiciness. PLoS Biology 07/2018; 16(7):e2004921., DOI:10.1371/journal.pbio.2004921

5.         Guo-Dong Wang, Bao-Lin Zhang, Wei-Wei Zhou, Yong-Xin Li, Jie-Qiong Jin, Yong Shao, He-chuan Yang, Yan-Hu Liu, Fang Yan, Hong-Man Chen, Li Jin, Feng Gao, Yaoguang Zhang, Haipeng Li, Bingyu Mao, Robert W. Murphy, David B. Wake, Ya-Ping Zhang, Jing Che: Selection and environmental adaptation along a path to speciation in the Tibetan frog Nanorana parkeri. Proceedings of the National Academy of Sciences 05/2018; 115(22):201716257., DOI:10.1073/pnas.1716257115

6.         Hechuan Yang, Guodong Wang, Meng Wang, Yaping Ma, Tingting Yin, Ruoxi Fan, Hong Wu, Li Zhong, David M. Irwin, Weiwei Zhai, Yaping Zhang: The origin of chow chows in the light of the East Asian breeds. BMC Genomics 12/2017; 18(1)., DOI:10.1186/s12864-017-3525-9

7.         Yan-Hu Liu, Lu Wang, Tao Xu, Xiaomin Guo, Yang Li, Ting-Ting Yin, He-Chuan Yang, Hu Yang, Adeniyi C Adeola, Oscar J Sanke, Newton O Otecko, Meng Wang, Yaping Ma, Olaogun S Charles, Mikkel-Holger S Sinding, Shyam Gopalakrishnan, José Alfredo Samaniego, Anders J Hansen, Carlos Fernandes, Philippe Gaubert, Jane Budd, Philip M Dawuda, Eli Knispel Rueness, Lubin Jiang, Weiwei Zhai, M Thomas P Gilbert, Min-Sheng Peng, Xiaopeng Qi, Guo-Dong Wang#, Ya-Ping Zhang: Whole-Genome Sequencing of African Dogs Provides Insights into Adaptations against Tropical Parasites. Molecular Biology and Evolution 10/2017; 35(2)., DOI:10.1093/molbev/msx258

8.         Adeniyi C. Adeola, Sheila C. Ommeh, Jiao-Jiao Song, S. Charles Olaogun, Oscar J. Sanke, Ting-Ting Yin, Guo-Dong Wang, Shi-Fang Wu, Zhong-Yin Zhou, Jacqueline K. Lichoti, Bernard R. Agwanda, Philip M. Dawuda, Robert W. Murphy, Min-Sheng Peng, Ya-Ping Zhang: A cryptic mitochondrial DNA link between North European and West African dogs. Journal of Genetics and Genomics 03/2017; 44(3):163-170.

9.         Zeinab Amiri Ghanatsaman, Adeniyi C. Adeola, Masood Asadi Fozi, Ya-Ping Ma, Min-Sheng Peng, Guo-Dong Wang, Ali Esmailizadeh, Ya-Ping Zhang: Mitochondrial DNA sequence variation in Iranian native dogs. 03/2017; 29(3):1-9., DOI:10.1080/24701394.2017.1289375

10.     Newton O Otecko, Min-Sheng Peng, He-Chuan Yang, Ya-Ping Zhang, Guo-Dong Wang#: Re-evaluating data quality of dog mitochondrial, Y chromosomal, and autosomal SNPs genotyped by SNP array. Zoological Research 12/2016; 37(6):358-362., DOI:10.13918/j.issn.2095-8137.2016.6.358

11.     Lu WANG, Ya-Ping MA, Qi-Jun ZHOU, Ya-Ping ZHANG, Peter SAVOLAINEN, Guo-Dong WANG#: The geographical distribution of grey wolves (Canis lupus) in China: a systematic review. Zoological Research 11/2016; 37(6):315-326., DOI:10.13918/j.issn.2095-8137.2016.6.315

12.     Adeniyi Charles Adeola, Guo-Dong Wang, Sheila C Ommeh, Robert W Murphy, Sunday Olaogun: A cryptic mitochondrial DNA link between North European and West African dogs. Journal of Genetics and Genomics 10/2016; 44(3)., DOI:10.1016/j.jgg.2016.10.008

13.     Hong Wu, Yan-Hu Liu, Guo-Dong Wang, Chun-Tao Yang, Newton O. Otecko, Fei Liu, Shi-Fang Wu, Lu Wang, Li Yu, Ya-Ping Zhang: Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome. Scientific Reports 10/2016; 6:35004., DOI:10.1038/srep35004

14.     Mingqiang Rong, Jiangxin Liu, Meilin Zhang, Gan Wang, Gang Zhao, Guodong Wang, Yaping Zhang, Kaifeng Hu, Ren Lai: A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds. Scientific Reports 07/2016; 6:29691., DOI:10.1038/srep29691

15.     Li Yu, Guo-Dong Wang*, Jue Ruan, Yong-Bin Chen, Cui-Ping Yang, Xue Cao, Hong Wu, Yan-Hu Liu, Zheng-Lin Du, Xiao-Ping Wang, Jing Yang, Shao-Chen Cheng, Li Zhong, Lu Wang, Xuan Wang, Jing-Yang Hu, Lu Fang, Bing Bai, Kai-Le Wang, Na Yuan, Shi-Fang Wu, Bao-Guo Li, Jin-Guo Zhang, Ye-Qin Yang, Cheng-Lin Zhang, Yong-Cheng Long, Hai-Shu Li, Jing-Yuan Yang, David M Irwin, Oliver A Ryder, Ying Li, Chung-I Wu, Ya-Ping Zhang: Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nature Genetics 07/2016; 48(8)., DOI:10.1038/ng.3615

16.     Andrea Strakova, Máire Ní Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo Domracheva, Castro Karina F de, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Manrique Rodrigo F H?felin, Joaquim JGP Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Quintana Adriana M Lopez, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Casta?eda Simón Martínez, Mayra F Martínez-López, Michael Meyer, Berna Nakanwagi, Nardi Andrigo B De, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth J Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vi??laru, Vos Anna P de, Vos Johan P de, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, der Wel Mirjam G van, Sophie AE Widdowson, Elizabeth Proby Murchison: Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer. eLife 05/2016; 5., DOI:10.7554/eLife.14552

17.     Guo-Dong Wang, Min-Sheng Peng, He-Chuan Yang, Peter Savolainen, Ya-Ping Zhang: Questioning the evidence for a Central Asian domestication origin of dogs. Proceedings of the National Academy of Sciences 04/2016; 113(19)., DOI:10.1073/pnas.1600225113

18.     Guo-Dong Wang, Weiwei Zhai, He-Chuan Yang, Lu Wang, Li Zhong, Yan-Hu Liu, Ruo-Xi Fan, Ting-Ting Yin, Chun-Ling Zhu, Andrei D Poyarkov, David M Irwin, Marjo K Hyt?nen, Hannes Lohi, Chung-I Wu, Peter Savolainen, Ya-Ping Zhang: Out of southern East Asia: The natural history of domestic dogs across the world. Cell Research 12/2015; 26(1)., DOI:10.1038/cr.2015.147

19.     Kexin Li, Wei Hong, Hengwu Jiao, Guo-Dong Wang, Karl A Rodriguez, Rochelle Buffenstein, Yang Zhao, Eviatar Nevo, Huabin Zhao: Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax. Proceedings of the National Academy of Sciences 09/2015; 112(38)., DOI:10.1073/pnas.1514896112

20.     Ruoxi Fan, Fei Liu, Hong Wu, Shifang Wu, Chunling Zhu, Yan Li, Guodong Wang#, Yaping Zhang: A Positive Correlation between Elevated Altitude and Frequency of Mutant Alleles at the EPAS1 and HBB Loci in Chinese Indigenous Dogs. Journal of Genetics and Genomics 03/2015; 7(4)., DOI:10.1016/j.jgg.2015.02.006

21.     Xue Cao, Yan-Bo Sun, David M Irwin, Guo-Dong Wang#, Ya-Ping Zhang: Nocturnal to Diurnal Transition in the Common Ancestor of Haplorrhines: Evidence from Genomic-Scan for Positively Selected Genes. Journal of Genetics and Genomics 01/2015; 42(1):33-37., DOI:10.1016/j.jgg.2014.11.004

22.     Bing Bai, Wen-Ming Zhao, Bi-Xia Tang, Yan-Qing Wang, Lu Wang, Zhang Zhang, He-Chuan Yang, Yan-Hu Liu, Jun-Wei Zhu, David M Irwin, Guo-Dong Wang#, Ya-Ping Zhang: DoGSD: the dog and wolf genome SNP database. Nucleic Acids Research 11/2014; 43(D1)., DOI:10.1093/nar/gku1174

23.     Yan Li, Guo-Dong Wang#, Ming-Shan Wang, David M Irwin, Dong-Dong Wu, Ya-Ping Zhang: Domestication of the Dog from the Wolf Was Promoted by Enhanced Excitatory Synaptic Plasticity: A Hypothesis. Genome Biology and Evolution 11/2014; 6(11)., DOI:10.1093/gbe/evu245

24.     Xue Cao, David M Irwin, Yan-Hu Liu, Lu-Guang Cheng, Lu Wang, Guo-Dong Wang#, Ya-Ping Zhang: Balancing Selection on CDH2 May Be Related to the Behavioral Features of the Belgian Malinois. PLoS ONE 10/2014; 9(10):e110075., DOI:10.1371/journal.pone.0110075

25.     Guo-Dong Wang, Ruo-Xi Fan, Weiwei Zhai, Fei Liu, Lu Wang, Li Zhong, Hong Wu, He-Chuan Yang, Shi-Fang Wu, Chun-Ling Zhu, Yan Li, Yun Gao, Ri-Li Ge, Chung-I Wu, Ya-Ping Zhang: Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau. Genome Biology and Evolution 08/2014; 6(8)., DOI:10.1093/gbe/evu162

26.     Yan Li, Dong-Dong Wu, Adam R Boyko, Guo-Dong Wang, Shi-Fang Wu, David M Irwin, Ya-Ping Zhang: Population Variation Revealed High-Altitude Adaptation of Tibetan Mastiffs. Molecular Biology and Evolution 02/2014; 31(5)., DOI:10.1093/molbev/msu070

27.     Guo-Dong Wang, Hai-Bing Xie, Min-Sheng Peng, David Irwin, Ya-Ping Zhang: Domestication Genomics: Evidence from Animals. Annual Review of Animal Biosciences 02/2014; 2(1):65-84., DOI:10.1146/annurev-animal-022513-114129

28.     Guo-Dong Wang, Weiwei Zhai, He-Chuan Yang, Ruo-Xi Fan, Xue Cao, Li Zhong, Lu Wang, Fei Liu, Hong Wu, Lu-Guang Cheng, Andrei D Poyarkov, Nikolai A Poyarkov Jr, Shu-Sheng Tang, Wen-Ming Zhao, Yun Gao, Xue-Mei Lv, David M Irwin, Peter Savolainen, Chung-I Wu, Ya-Ping Zhang: The genomics of selection in dogs and the parallel evolution between dogs and humans. Nature Communications 05/2013; 4:1860., DOI:10.1038/ncomms2814

29.     Guo-Dong Wang, Lu-Guang Cheng, Ruo-Xi Fan, David M Irwin, Shu-Sheng Tang, Jian-Guo Peng, Ya-Ping Zhang: Signature of Balancing Selection at the MC1R Gene in Kunming Dog Populations. PLoS ONE 02/2013; 8(2):e55469., DOI:10.1371/journal.pone.0055469

30.     Yin-Qiu Ji, Dong-Dong Wu, Gui-Sheng Wu, Guo-Dong Wang, Ya-Ping Zhang: Multi-Locus Analysis Reveals A Different Pattern of Genetic Diversity for Mitochondrial and Nuclear DNA between Wild and Domestic Pigs in East Asia. PLoS ONE 10/2011; 6(10):e26416., DOI:10.1371/journal.pone.0026416

31.     GuoDong Wang, ZhouHai Zhu, Peng Shi, YaPing Zhang: Comparative genomic analysis reveals more functional nasal chemoreceptors in nocturnal mammals than diurnal mammals. Chinese Science Bulletin 12/2010; 55(34):3901-3910., DOI:10.1007/s11434-010-4202-4

32.     Guodong Wang, Peng Shi, Zhouhai Zhu, Ya-ping Zhang: More Functional V1R Genes Occur in Nest-Living and Nocturnal Terricolous Mammals. Genome Biology and Evolution 05/2010; 2(1):277-83., DOI:10.1093/gbe/evq020

33.     Ruiqiang Li, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, Jing Cai, Quanfei Huang, Qingle Cai, Bo Li, Yinqi Bai, Zhihe Zhang, Yaping Zhang, Wen Wang, Jun Li, Fuwen Wei, Heng Li, Min Jian, Jianwen Li, Zhaolei Zhang, Rasmus Nielsen, Dawei Li, Wanjun Gu, Zhentao Yang, Zhaoling Xuan, Oliver A Ryder, Frederick Chi-Ching Leung, Yan Zhou, Jianjun Cao, Xiao Sun, Yonggui Fu, Xiaodong Fang, Xiaosen Guo, Bo Wang, Rong Hou, Fujun Shen, Bo Mu, Peixiang Ni, Runmao Lin, Wubin Qian, Guodong Wang, Chang Yu, Wenhui Nie, Jinhuan Wang, Zhigang Wu, Huiqing Liang, Jiumeng Min, Qi Wu, Shifeng Cheng, Jue Ruan, Mingwei Wang, Zhongbin Shi, Ming Wen, Binghang Liu, Xiaoli Ren, Huisong Zheng, Dong Dong, Kathleen Cook, Gao Shan, Hao Zhang, Carolin Kosiol, Xueying Xie, Zuhong Lu, Hancheng Zheng, Yingrui Li, Cynthia C Steiner, Tommy Tsan-Yuk Lam, Siyuan Lin, Qinghui Zhang, Guoqing Li, Jing Tian, Timing Gong, Hongde Liu, Dejin Zhang, Lin Fang, Chen Ye, Juanbin Zhang, Wenbo Hu, Anlong Xu, Yuanyuan Ren, Guojie Zhang, Michael W Bruford, Qibin Li, Lijia Ma, Yiran Guo, Na An, Yujie Hu, Yang Zheng, Yongyong Shi, Zhiqiang Li, Qing Liu, Yanling Chen, Jing Zhao, Ning Qu, Shancen Zhao, Feng Tian, Xiaoling Wang, Haiyin Wang, Lizhi Xu, Xiao Liu, Tomas Vinar, Yajun Wang, Tak-Wah Lam, Siu-Ming Yiu, Shiping Liu, Hemin Zhang, Desheng Li, Yan Huang, Xia Wang, Guohua Yang, Zhi Jiang, Junyi Wang, Nan Qin, Li Li, Jingxiang Li, Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang, Jun Wang: The sequence and de novo assembly of the giant panda genome. Nature 02/2010; 463(7284):1106., DOI:10.1038/nature08846

34.     Dong-Dong Wu, Guo-Dong Wang, David M Irwin, Ya-Ping Zhang: A Profound Role for the Expansion of Trypsin-Like Serine Protease Family in the Evolution of Hematophagy in Mosquito. Molecular Biology and Evolution 08/2009; 26(10):2333-41., DOI:10.1093/molbev/msp139

  研究团队

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