硕士生导师     首页 > 研究队伍
肖潇  副研究员
转化基因组学科组
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电子邮件: xiaoxiao2@mail.kiz.ac.cn
通讯地址: 云南省昆明市龙欣路17号    650201
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  简  历

肖潇,博士,中国科学院昆明动物研究所转化基因组学科组副研究员。2016年于美国约翰霍普金斯大学公共卫生学院获博士学位,主持多项国家自然科学基金和云南省自然科学基金项目,获云南省优秀青年基金资助,并入选云岭青年人才、中国科学院西部青年学者以及中国科学院青年创新促进会。长期从事人类复杂精神疾病及相关性状的遗传学研究,过去几年来开展了一系列针对精神分裂症及情感障碍等疾病的遗传和分子机制的探索,以第一或通讯作者身份在Molecular PsychiatryBiological PsychiatrySchizophrenia BulletinNeuropsychopharmacologyTranslational Psychiatry等杂志发表SCI论文十余篇,并担任Molecular PsychiatryWorld Journal of Biological PsychiatryScientific Reports等杂志审稿人。

  研究方向

以精神分裂症(SZ)、双相情感障碍(BD)和抑郁症(MDD)为代表的常见精神疾病在全世界范围内均造成了沉重的社会与经济负担,但囿于对其发病机制认识的欠缺,目前针对这些疾病的诊断仍缺少有效的生物学标记,且已有疗法效果不尽理想。过往研究表明这些精神疾病具有较高遗传力,提示遗传风险因素在其发病中的作用;而多种重性精神疾病往往具有较高的遗传关联以及部分相似的临床表型。这一特征提示需整合基因组、转录组、表观组等精神疾病的多组学数据,结合相关神经分子生物学分析,从功能基因组学(Functional genomics)及表型组学(phenomics)角度对其共有及独有的关键遗传风险和机制展开解析,从而为开发针对性临床分型和诊疗提供依据。聚焦这一核心问题,本团队的主要研究目标为通过整合多组学数据,结合实验生物学手段解析精神疾病遗传风险位点与基因参与疾病或有关表型的可能机制,通过关注不同精神疾病跨诊断遗传风险和表型的遗传与分子机制,力图为针对性干预诊疗提供潜在靶标。

  承担科研项目

1、中国科学院青年创新促进会,2018-01-01 - 2021-12-3180.0万元,中国科学院计划,主持;

2、基于多组学分析探索精神疾病的遗传基础与生物学机制,2021-06-01 - 2024-05-3130.0万元,云南省优秀青年基金,主持; 

3、抑郁症风险基因PCDH9在发病过程中的生物学机制研究,2021-01-01 - 2024-12-355.0万元,国家自然科学基金面上项目,主持。
  专家类别
  社会任职
 
  获奖及荣誉
 
  代表论著

1.Chen Zhang,# Xiao Xiao,# Tao Li,* Ming Li.* Translational genomics and beyond in bipolar disorder. Molecular Psychiatry 2021; 26(1):186-202.

2.Zhihui Yang,# Danyang Zhou,# Huijuan Li,# Xin Cai, Weipeng Liu, Lu Wang, Hong Chang, Ming Li,* Xiao Xiao.* The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine. Molecular Psychiatry 2020; 25(2):48-66.  

3.Xiao Xiao, Chen Zhang,* Maria Grigoroiu-Serbanescu,* Lu Wang, Lingyi Li, Dongsheng Zhou, Ti-Fei Yuan, Chuang Wang, Hong Chang, Yong Wu, Yan Li, Dong-Dong Wu, Yong-Gang Yao, Ming Li.* The cAMP responsive-element binding (CREB)-1 gene increases risk of major psychiatric disorders. Molecular Psychiatry 2018; 23(9):1957-1967. 

4.Hong Chang,# Xiao Xiao,# Ming Li.* The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. Molecular Psychiatry 2017; 22(7),944-953. 

5.Hong Chang,# Xin Cai,# Hui-Juan Li,# Wei-Peng Liu, Li-Juan Zhao, Chu-Yi Zhang, Jun-Yang Wang, Jie-Wei Liu, Xiao-Lei Ma, Lu Wang, Yong-Gang Yao, Xiong-Jian Luo, Ming Li,* Xiao Xiao.* Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus. Biological Psychiatry 2021; 89(3):246-255. 

6.Huijuan Li, Chuyi Zhang, Xin Cai, Lu Wang, Fang Luo, Yina Ma, Ming Li,* Xiao Xiao,* GeseDNA Research Team. Genome-wide association study of creativity reveals genetic overlap with psychiatric disorders, risk tolerance, and risky behaviors. Schizophrenia Bulletin 2020; 46(5):1317-1326. 

7.Jun-Yang Wang,# Xiao-Yan Li,# Hui-Juan Li,# Jie-Wei Liu, Yong-Gang Yao, Ming Li, Xiao Xiao,* Xiong-Jian Luo.* Integrative analyses followed by functional characterization reveal TMEM180 as a schizophrenia risk gene. Schizophrenia Bulletin 2021 Mar 26;sbab032. 

8.Weipeng Liu,# Wenqiang Li,# Xin Cai,# Zhihui Yang,# Huijuan Li, Xi Su, Meng Song, Dong-Sheng Zhou, Xingxing Li, Chen Zhang, Minglong Shao, Luwen Zhang, Yongfeng Yang, Yan Zhang, Jingyuan Zhao, Hong Chang, Yong-Gang Yao, Yiru Fang, Luxian Lv,* Ming Li,* Xiao Xiao.* Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci. Neuropsychopharmacology 2020; 45(7):1196-1206. 

9.Huijuan Li,# Hong Chang,# Xueqin Song,# Weipeng Liu, Lingyi Li, Lu Wang, Yongfeng Yang, Luwen Zhang, Wenqiang Li, Yan Zhang, Dong-Sheng Zhou, Xingxing Li, Chen Zhang, Yiru Fang, Yan Sun, Jia-Pei Dai, Xiong-Jian Luo, Yong-Gang Yao, Xiao Xiao,* Luxian Lv,* Ming Li.* Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. Neuropsychopharmacology 2019; 44(9):1552-1561. 

10.Xiao Xiao,# Fanfan Zheng,# Hong Chang, Yina Ma, Yong-Gang Yao, Xiong-Jian Luo, Ming Li.* The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder. Neuropsychopharmacology 2018; 43(5):1128-1137. 

11.Hui-Juan Li,# Na Qu,# Li Hui,# Xin Cai, Chu-Yi Zhang, Bao-Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Lu Wang, Qiu-Fang Jia, Wei Li, Hong Chang, Xiao Xiao,* Ming Li,* Yi Li.* Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data. Translational Psychiatry 2020; 10(1):98. 

12.Weipeng Liu,# Hao Yan,# Danyang Zhou,# Xin Cai,# Yuyanan Zhang, Shiyi Li, Huijuan Li, Shiwu Li, Dong-Sheng Zhou, Xingxing Li, Chen Zhang, Yan Sun, Jia-Pei Dai, Jingmei Zhong, Yong-Gang Yao, Xiong-Jian Luo, Yiru Fang, Dai Zhang, Yina Ma, Weihua Yue,* Ming Li,* Xiao Xiao.* The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population. Translational Psychiatry 2019; 9(1):333. 

13.Lijuan Zhao,# Hong Chang,# Dong-Sheng Zhou,# Jun Cai, Weixing Fan, Wei Tang, Wenxin Tang, Xingxing Li, Weiqing Liu, Fang Liu, Yuanfang He, Yan Bai, Yan Sun, Jiapei Dai, Lingyi Li, Xiao Xiao,* Chen Zhang,* Ming Li.* Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. Translational Psychiatry 2018; 8:270. 

14.Xiao Xiao, Lu Wang, Chuang Wang, Ti-Fei Yuan, Dongsheng Zhou, Fanfan Zheng, Lingyi Li, Maria Grigoroiu-Serbanescu, Masashi Ikeda, Nakao Iwata, Atsushi Takahashi, Yoichiro Kamatani, Michiaki Kubo, Martin Preisig, Zoltán Kutalik, Enrique Castelao, Giorgio Pistis, Najaf Amin, Cornelia M van Duijn, Andreas J Forstner, Jana Strohmaier, Julian Hecker, Thomas G Schulze, Bertram Müller-Myhsok, Andreas Reif, Philip B Mitchell, Nicholas G Martin, Peter R Schofield, Sven Cichon, Markus M N?then, Hong Chang, Xiong-Jian Luo, Yiru Fang, Yong-Gang Yao, Chen Zhang, Marcella Rietschel, Ming Li.* Common variants at 2q11.2, 8q21.3 and 11q13.2 are associated with major mood disorders. Translational Psychiatry 2017; 7(12):1273.
  研究团队

 

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