简历 

马鹏程，博士，副研究员，硕士生导师。主要以非洲爪蛙、文昌鱼和小鼠为模式动物从事脊椎动物神经系统发育和演化机制的研究。目前，已在Nature communications、Cell Death and Differentiation、Cell Reports和Development等杂志发表研究论文十余篇；获得国家自然科学基金青年基金、中国科学院“西部之光”-西部博士以及云南省应用基础研究计划面上项目等项目资助。 

学习和工作经历 

2019/01-  至今  中国科学院昆明动物研究所，副研究员 

2013/07-2018/12  中国科学院昆明动物研究所，助理研究员 

2008/09-2013/07  中国科学院昆明动物研究所，博士 

2004/09-2008/07  鲁东大学，生命科学学院，学士 

1．脊椎动物神经系统发育的调控机制

2．遗传性神经系统罕见疾病的致病机理 

3．神经系统进化发育调控研究 

1.中国科学院青年创新促进会人才专项，2021/01-2024/12，80万，主持 

2.中国科学院“西部之光”人才培养计划“西部博士”项目，泛素连接酶RNF220调控Wnt信号通路的机制及其在肿瘤发生中的功能，2013/09-2016/09，20万，主持 

3.国家自然科学基金青年基金项目，泛素连接酶RNF220在中枢去甲肾上腺素能神经元发育中的功能研究，31500847，2016/01-2018/12，20万，主持 

4.云南省应用基础研究计划项目面上项目，泛素连接酶RNF220在脑干蓝斑核神经元发育中的功能及作用机制，C0120150169，2016/10-2019/09，10万，主持 

 2021年，入选中国科学院青年创新促进会

 （^#co-first author; *Corresponding author）

1.Huishan Wang, Chencheng Yang, Yuwei Li, Pengcheng Ma* and Bingyu Mao*. (2021) RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6. Biochemical and Biophysical Research Communications 557: 323-328 

2.Pengcheng Ma^#, Yuwei Li^#, Huishan Wang, Shuhua Zhao and Bingyu Mao*. (2021) Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse. Journal of Molecular Cell Biology mjaa072 

3.Xiaomin Guo^#, Pengcheng Ma^#, Yuwei Li, Chaoming Wang, Tao Xu, Huishan Wang, Chaocui Li, Bingyu Mao*, and Xiaopeng Qi*. (2021) RNF220 mediated K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death and Differentiation 28(2): 640-656 

4.Ning-Ning Song^#, Pengcheng Ma^#, Qiong Zhang, Lei Zhang, Longlong Zhang, Liang Zhu, Chui-Hui He, Bingyu Mao*, and Yu-Qiang Ding*. (2020) RNF220/ZC4H2-mediated monoubiquitination of Phox2 is requried for the development of central noradrenergic neurons. Development 147(6): dev185199 

5.Pengcheng Ma^#, Tao An^#, Liang Zhu, Longlong Zhang, Huishan Wang, Biyu Ren, Bin Sun, Xia Zhou, Yan Li*, and Bingyu Mao*. (2020) RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling. Development 147(21): dev188078 

6.Shao-jie Zhang^#, Guo-Dong Wang^#, Pengcheng Ma^#, Liang-liang Zhang, Ting-Ting YIN, Yan-hu Liu, Newton O. Otecko, Meng Wang, Ya-ping Ma, Lu Wang, Bingyu Mao*, Peter Savolainen*, and Ya-ping Zhang*. (2020) Genomic regions under selection in the feralization of the dingoes. Nature Communications 11(1): 671 

7.Pengcheng Ma^#, Ning-Ning Song^#, Xiaoning Cheng^#, Liang Zhu, Qiong Zhang, Longlong Zhang, Xiangcai Yang, Huishan Wang, Qinghua Kong, Deli Shi*, Yu-Qiang Ding*, and Bingyu Mao*. (2020) ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. Journal of Molecular Cell Biology 12(5): 337-344 (Featured Article) 

8.Lei Zhang^#, Ning-Ning Song^#, Qiong Zhang^#, Chun-Hui He, Xin Yu, Pengcheng Ma, Ying Huang, Jia-Yin Chen, Bingyu Mao, Bing Lang, and Yu-Qiang Ding*. (2019) Satb2 is required for the regionalization of retrosplenial cortex. Cell Death and Differentiation 27(5): 1604-1617 

9.Pengcheng Ma^#, Ning-Ning Song^#, Yongxin Li^#, Qiong Zhang, Lei Zhang, Qinghua Kong, Li Ma, Xiangcai Yang, Biyu Ren, Chaocui Li, Xudong Zhao, Yan Li, Xiang Gao*, Yu-Qiang Ding_*, and Bingyu Mao*. (2019) Fine-turning of Shh/Gli signaling gradient by non-proteolytic ubiquitination during neural patterning. Cell Reports 28(2): 541-553 

10.Xia Zhou^#, Yadong Yang^#, Pengcheng Ma, Na Wang, Dong Yang, Qiu Tu, Bin Sun, Tingxiu Xiang, Xudong Zhao, Zongliu Hou*, Xiangdong Fang*. (2019) TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway. Journal of Neuro-Oncology 145(2): 211-222 

11.Zhaohui Yang^#, Hong Shi^#, Pengcheng Ma^#, Shilei Zhao, Qinghong Kong, Tianhao Bian, Chao Gong, Qi Zhao, Yuan Liu, Xuebin Qi, Xiaoming Zhang, Yinglun Han, Jiewei Liu, Qingwei Li, Huan Chen*, and Bing Su*. (2018) Darwinian positive selection on the pleiotropic effects of KITLG explain skin pigmentation and winter temperature adaptation in Eurasians. Molecular Biology and Evolution 35(9): 2272-2283 

12.Pengcheng Ma^#, *, Biyu Ren^#, Xiangcai Yang^#, Bin Sun, Xiaoliang Liu, Qinghua Kong, Chaocui Li and Bingyu Mao*. (2017) ZC4H2 stabilizes Smads to enhance BMP signaling, which is involved in neural development in Xenopus. Open Biology 7(8): 170122 

13.Xiaoliang Liu^#, Yingjie Xia^#, Jixin Tang, Li Ma, Chaocui Li, Pengcheng Ma* and Bingyu Mao*. (2017) Dual roles of Akirin2 during Xenopus neural development. The Journal of Biological Chemistry 292(14): 5676-5684 

14.Tao An, Yaxiao Gong, Xue Li, Lingmei Kong, Pengcheng Ma, Liang Gong, Huifang Zhu, Chunlei Yu, Jianmei Liu, Hongyu Zhou, Bingyu Mao and Yan Li. (2017) USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochemical Pharmacology 131: 29-39 

15.Xiaoliang Liu, Xiangcai Yang, Yongxin Li, Shuhua Zhao, Chaocui Li, Pengcheng Ma* and Bingyu Mao*. (2016) Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response. FEBS Letters 590(23): 4213-4222 

16.Xingyao Li, Bai Bing, Li Liu, Pengcheng Ma, Lingmei Kong, Juming Yan, Jing Zhang, Zhennan Ye, Hongyu Zhou, Bingyu Mao, Huajie Zhu and Yan Li. (2015) Novel β-carbolines against colorectal cancer cell growth via inhibition of Wnt/β-catenin signaling. Cell Death Discovery 1: 15033 

17.Pengcheng Ma, Xiangcai Yang, Qinghua Kong, Shuangjuan Yang, Yan Li and Bingyu Mao. (2014) The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7 mediated deubiquitination of β-catenin. Molecular and Cellular Biology 34 (23): 4355-4366 

18.Pengcheng Ma^#, Yingjie Xia^#, Li Ma, Shuhua Zhao, Bingyu Mao*. (2013) Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development. Development Genes and Evolution 223(4): 253-259 

19.Pengcheng Ma^#, Shuhua Zhao^#, Wanli Zeng, Qiutan Yang, Chaocui Li, Xiaoyan Lv, Qin Zhou, Bingyu Mao*. (2011) Xenopus Dbx2 is involved in primary neruogenesis and early neural plate patterning. Biochemical and Biophysical Research Communications 412(1): 170-174