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常宏  副研究员
转化基因组学科组
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电子邮件: changhong@mail.kiz.ac.cn
通讯地址: 云南省昆明市龙欣路17号    650201
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  简  历

简历 

主要从事疾病功能基因组解析的相关研究,即通过生物信息学方法鉴定人类基因组中与疾病发生显著相关的遗传变异及风险基因,并结合基因编辑、分子遗传学及神经生物学方法,进一步分析风险遗传变异调控靶基因表达的分子机制及风险基因参与疾病发生的分子机理。近5年在Biol PsychiatryMol PsychiatrySchizophr BullNeuropsychopharmacology等杂志发表第一作者(含共同第一)及通讯作者SCI论文15篇,已申请并主持国家自然科学基金面上项目(在研)及青年项目(已结题),于2018年入选云南省高层次人才引进计划青年人才   

学习和工作经历 

1. 2017/01-至今,中国科学院昆明动物研究所,转化基因组,副研究员 

2. 2016/07-2016/12,中国科学院昆明动物研究所,转化基因组,助理研究员 

3. 2014/01-2016/06,美国南阿拉巴马大学Mitchell肿瘤研究所,博士后 

4. 2011/07-2013/09,中国科学院昆明动物研究所,分子病理组,助理研究员 

5. 2008/09-2011/07,中国科学院昆明动物研究所,细胞生物学,博士 

6. 2005/09-2008/07,云南大学,生命科学学院,细胞及分子生物学,硕士 

7. 2001/09-2005/07,云南大学,生命科学学院,生物技术,学士 

  研究方向

 精神疾病功能基因组解析

  承担科研项目
1.国家自然科学基金-面上项目,82071534,双相情感障碍易感基因Trank1的功能研究,2021/01-2024/1255万元,在研,主持。

2.云南省高层次人才引进计划“青年人才”-项目培养经费支持,2020-18号,遗传风险基因Trank1参与双相情感障碍发病的机制研究,2020/02-2024/12100万元,在研,主持。 

3.国家自然科学基金-面上项目,81871067,遗传风险基因PCDH17参与心境障碍发病的机制研究,2019/01-2022/1256万元,在研,主持。 

4.河南省生物精神病学重点实验室开放课题,ZDSYS2018001,中国人群中Setd1A基因内罕见外显子突变与精神分裂症的易感性分析,2019/01-2021/125万元,在研,主持。 

5.云南省基础研究专项-面上项目,2018FB136,硫化舒林酸诱导Snail蛋白降解进而抑制肠癌细胞转移的分子机制,2018/06-2021/0510万元,在研,主持。 

6.国家自然科学基金-青年项目,81201667Symplekin 在细胞间黏附及肿瘤发生发展中的功能研究,2013/01-2015/1223万元,已结题,主持。 

7.国家自然科学基金-地区项目,81960662,组蛋白去乙酰化酶HDAC8调节原肌球蛋白TPM3巴豆酰化修饰对血管舒张的作用及机制研究,2020/01-2023/1235万元,在研,参加。 

8.国家自然科学基金-面上项目,81272617,新的肺癌相关基因MCRS1异常表达与肿瘤细胞增殖、浸润的关系及机理,2013/01-2016/1270万元,已结题,参加。 

  专家类别
  社会任职
 
  获奖及荣誉

 1. 云南省高层次人才引进计划“青年人才,2018

  代表论著

 第一作者(含共同第一作者)及通讯作者论文(#共同第一作者,*共同通讯作者):

1.Chang H., Cai X., Yang Z.H, Xiao X., Li M*. (2021) Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions. Mol Psychiatry. Online ahead of print.中科院JCR分区:医学1区;当年影响因子:12.384 

2.Chang H.#, Cai X.#, Li H.J.#, Liu W.P., Zhao L.J., Zhang C.Y., Wang J.Y., Liu J.W., Ma X.L., Wang L., Yao Y.G., Luo X.J., Li M.*, Xiao X.* (2021) Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus. Biol Psychiatry 89, 246-255. DOI: 10.1016/j.biopsych.2020.09.016.(封面论文;中科院JCR分区:医学1区;当年影响因子:12.095 

3.Chang H.#, Hoshina N.#, Zhang C.#, Ma Y., Cao H., Wang Y., Wu D.D., Bergen S.E., Landen M., Hultman C.M., Preisig M., Kutalik Z., Castelao E., Grigoroiu-Serbanescu M., Forstner A.J., Strohmaier J., Hecker J., Schulze T.G., Muller-Myhsok B., Reif A., Mitchell P.B., Martin N.G., Schofield P.R., Cichon S., Nothen M.M., Swedish Bipolar Study G., Moo D.S.B.C., Walter H., Erk S., Heinz A., Amin N., van Duijn C.M., Meyer-Lindenberg A., Tost H., Xiao X., Yamamoto T.*, Rietschel M.*, Li M.* (2018). The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders. Mol Psychiatry 23, 400-412. DOI: 10.1038/mp.2016.231.中科院JCR分区:医学1区;当年影响因子:11.973 

4.Chang H.#, Xiao X.#, Li M.* (2017). The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. Mol Psychiatry 22, 944-953. DOI: 10.1038/mp.2017.19.中科院JCR分区:医学1区;当年影响因子:11.64 

5.Cai X.#, Yang Z.H.#, Li H.J., Xiao X., Li M.*, Chang H.* (2021). A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density. Schizophr Bull 47, 219-227. DOI: 10.1093/schbul/sbaa098.中科院JCR分区:医学1区;当年影响因子:7.958 

6.Li W.#, Cai X.#, Li H.J.#, Song M.#, Zhang C.Y., Yang Y., Zhang L., Zhao L., Liu W., Wang L., Shao M., Zhang Y., Zhang C., Cai J., Zhou D.S., Li X., Hui L., Jia Q.F., Qu N., Zhong B.L., Zhang S.F., Chen J., Xia B., Li Y., Song X., Fan W., Tang W., Tang W., Tang J., Chen X., Yue W., Zhang D., Fang Y., Xiao X., Li M.*, Lv L.*, Chang H.* (2021). Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. Neuropsychopharmacology 46, 1103-1112. DOI: 10.1038/s41386-020-00788-4.中科院JCR分区:医学1区;当年影响因子:6.751 

7.Li H.#, Chang H.#, Song X.#, Liu W., Li L., Wang L., Yang Y., Zhang L., Li W., Zhang Y., Zhou D.S., Li X., Zhang C., Fang Y., Sun Y., Dai J.P., Luo X.J., Yao Y.G., Xiao X.*, Lv L.*, Li M.* (2019). Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. Neuropsychopharmacology 44, 1552-1561. DOI: 10.1038/s41386-019-0346-3.中科院JCR分区:医学1区;当年影响因子:6.751 

8.Zhao L.#, Chang H.#, Zhou D.S.#, Cai J., Fan W., Tang W., Tang W., Li X., Liu W., Liu F., He Y., Bai Y., Sun Y., Dai J., Li L., Xiao X.*, Zhang C.*, Li M.* (2018). Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. Transl Psychiatry 8, 270. DOI: 10.1038/s41398-018-0337-x.(中科院JCR分区:医学2区;当年影响因子:5.182 

9.Chang H.#, Li L.#, Peng T.#, Grigoroiu-Serbanescu M., Bergen S.E., Landen M., Hultman C.M., Forstner A.J., Strohmaier J., Hecker J., Schulze T.G., Muller-Myhsok B., Reif A., Mitchell P.B., Martin N.G., Cichon S., Nothen M.M., Jamain S., Leboyer M., Bellivier F., Etain B., Kahn J.P., Henry C., Rietschel M., Swedish Bipolar Study G., Moo D.S.C., Xiao X.*, Li M.* (2017). Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1. Mol Neurobiol 54, 5166-5176. DOI: 10.1007/s12035-016-0041-x.(中科院JCR分区:医学2区;当年影响因子:5.076 

10.Xiao X.#, Luo X.J.#, Chang H.#, Liu Z., Li M.* (2017). Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses. Mol Neurobiol 54, 4071-4080. DOI: 10.1007/s12035-016-9990-3.(中科院JCR分区:医学2区;当年影响因子:5.076 

11.Chang H., Li L., Li M.*, Xiao X.* (2017). Rare and common variants at 16p11.2 are associated with schizophrenia. Schizophr Res 184, 105-108. DOI: 10.1016/j.schres.2016.11.031.(中科院JCR分区:医学2区;当年影响因子:3.958 

12.Li H.#, Zhou D.S.#, Chang H.#, Wang L., Liu W., Dai S.X., Zhang C., Cai J., Liu W., Li X., Fan W., Tang W., Tang W., Liu F., He Y., Bai Y., Hu Z., Xiao X., Gao L.*, Li M.* (2019). Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder. J Psychiatr Res 115, 165-175. DOI: 10.1016/j.jpsychires.2019.05.024.(中科院JCR分区:医学2区;当年影响因子:3.745 

13.Chang H.#, Yi B.#, Ma R., Zhang X., Zhao H., Xi Y.* (2016). CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo. Sci Rep 6, 22312. DOI: 10.1038/srep22312.(中科院JCR分区:综合性期刊3区;当年影响因子:4.259 

14.Chang H.#, Li L.#, Peng T., Li M.*, Gao L.*, Xiao X.* (2016). Replication analyses of four chromosomal deletions with schizophrenia via independent large-scale meta-analyses. Am J Med Genet B Neuropsychiatr Genet 171, 1161-1169. DOI: 10.1002/ajmg.b.32502.(中科院JCR分区:医学3区;当年影响因子:3.258 

15.Chang H.#, Zhang C.*, Xiao X., Pu X., Liu Z., Wu L., Li M.* (2016). Further evidence of VRK2 rs2312147 associated with schizophrenia. World J Biol Psychiatry 17, 457-466. DOI: 10.1080/15622975.2016.1200746.(中科院JCR分区:医学3区;当年影响因子:3.658 

  

其他作者论文: 

1.Li H.J., Qu N., Hui L., Cai X., Zhang C.Y., Zhong B.L., Zhang S.F., Chen J., Xia B., Wang L., Jia Q.F., Li W., Chang H., Xiao X., Li M., Li Y. (2020). Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data. Transl Psychiatry 10, 98. DOI: 10.1038/s41398-020-0777-y. 

2.Liu W., Li W., Cai X., Yang Z., Li H., Su X., Song M., Zhou D.S., Li X., Zhang C., Shao M., Zhang L., Yang Y., Zhang Y., Zhao J., Chang H., Yao Y.G., Fang Y., Lv L., Li M., Xiao X. (2020). Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci. Neuropsychopharmacology 45, 1196-1206. DOI: 10.1038/s41386-020-0659-2. 

3.Yang Z.H., Cai X., Qu N., Zhao L.J., Zhong B.L., Zhang S.F., Chen J., Xia B., Jiang H.Y., Zhou D.Y., Liu W.P., Chang H., Xiao X., Li Y., Li M. (2019). Identification of a functional 339-bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32. Zool Res, 1-7. DOI: 10.24272/j.issn.2095-8137.2020.014. 

4.Yang Z., Zhou D., Li H., Cai X., Liu W., Wang L., Chang H., Li M., Xiao X. (2020). The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine. Mol Psychiatry 25, 48-66. DOI: 10.1038/s41380-019-0592-0. 

5.Yang Y., Wang L., Li L., Li W., Zhang Y., Chang H., Xiao X., Li M., Lv L. (2018). Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations. Transl Psychiatry 8, 144. DOI: 10.1038/s41398-018-0211-x. 

6.Xiao X., Zhang C., Grigoroiu-Serbanescu M., Wang L., Li L., Zhou D., Yuan T.F., Wang C., Chang H., Wu Y., Li Y., Wu D.D., Yao Y.G., Li M. (2018). The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Mol Psychiatry 23, 1957-1967. DOI: 10.1038/mp.2017.243. 

7.Xiao X., Zheng F., Chang H., Ma Y., Yao Y.G., Luo X.J., Li M. (2018). The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder. Neuropsychopharmacology 43, 1128-1137. DOI: 10.1038/npp.2017.241. 

8.Xiao X., Yu H., Li J., Wang L., Li L., Chang H., Zhang D., Yue W., Li M. (2017). Further evidence for the association between LRP8 and schizophrenia. Schizophr Res. DOI: 10.1016/j.schres.2017.05.002.
  研究团队

 

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