简历 

毕蕊，女，博士，副研究员。从事阿尔茨海默病（AD）等神经精神疾病的遗传和分子机制研究，围绕线粒体这一细胞能量工厂的相关基因开展了系列工作，发现线粒体基因和变异通过影响线粒体功能而增加这些疾病的患病风险。并通过系统遗传分析，发现了一批与AD发病风险相关的基因。相关研究结果以第一作者或通讯作者（含并列）在American Journal of Human Genetics、Neuropsychopharmacology、Human Mutation、Neurobiology of Aging等国际期刊发表SCI论文16篇，参与专著撰写一篇，以合作作者发表论文20篇。主持国家自然科学基金青年基金和面上项目、云南省面上项目和云南省重点项目，入选中国科学院青年创新促进会会员和云南省万人计划青年拔尖人才。 

学习和工作经历 

2018. 01-现在 中国科学院昆明动物研究所，疾病机理遗传学与进化医学学科组，副研究员 

2015. 01-2017.12 中国科学院昆明动物研究所，疾病机理遗传学与进化医学学科组，助理研究员 

2009. 09-2014.12 中国科学院昆明动物研究所，获博士学位 

2005. 09-2009.06 云南大学生命科学学院，获学士学位 

1.阿尔茨海默病等神经精神疾病的遗传和分子机制 

1.2015年 云南省科学技术奖励二等奖(自然科学奖); 项目名称: Leber遗传性视神经病遗传易感分析; 获奖人员: 姚永刚、张阿梅、余丹丹、毕蕊. 

2.2015年 昆明市科学技术进步奖二等奖; 项目名称: 线粒体DNA突变对母系遗传性高血压影响的临床应用; 获奖人员: 郭皓，余丹丹，袁勇，郭立，毕蕊，田青，王玮，冯月梅，熊国昌 

3.2013年 三好学生标兵 

4.2012年 中国科学院大学 国家奖学金 

5.2012年 朱李月华优秀博士生奖 

6.2011年 中国科学院院长奖，优秀奖 

1.第一作者论文和通讯作者论文（含共同） 

(1)Bi R*, Zhang W, Zhang D-F, Xu M, Fan Y, Hu Q-X, Jiang H-Y, Tan L, Li T, Fang Y, Zhang C, Yao Y-G*, Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese. Neuropsychopharmacology, 2018, 43: 2264 - 2276. 

(2)Wang D^#, Fan Y^#, Malhi M^#, Bi R^#, Wu Y, Xu M, Yu X-F, Long H, Li Y-Y, Zhang D-F*, Yao Y-G*, Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese,  Am J Hum Genet, 2018, 102: 794 – 805. 

(3)Bi R^#, Kong L-L^#, Xu M, Li G-D, Zhang D-F, Alzheimer’s Disease Neuroimaging Initiative, Li T, Fang Y, Zhang C, Zhang B, Yao Y-G*, The Arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese, Mol Neurobiol, 2018, 55: 1217-1226. 

(4)Li H^#, Bi R^#, Fan Y, Wu Y, Tang Y, Li Z, He Y, Zhou J, Tang J*, Chen X*, Yao Y-G*, mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia, Mol Neurobiol, 2017, 54: 4343-4352. 

(5)Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG*, Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia, Schizophr Res, 2016, 171(1-3):200-206. 

(6)Wang HZ^#, Bi R^#, Hu QX, Xiang Q, Zhang C, Zhang DF, Zhang W, Ma X, Guo W, Deng W, Zhao L, Ni P, Li M, Fang Y, Li T, Yao YG*, Validating GWAS-identified risk loci for Alzheimer's disease in Han Chinese populations, Mol Neurobiol, 2016, 53(1):379-390. 

(7)Wang HZ^#, Bi R^#, Zhang DF, Li GD, Ma XH, Fang Y, Li T, Zhang C, Yao YG*, Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese, Mol Neurobiol, 2016, 53: 4883-92. 

(8)Bi R, Zhang W, Yu D, Li X, Wang HZ, Hu QX, Zhang C, Lu W, Ni J, Fang Y, Li T, Yao YG*, Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese, Neurobiol Aging, 2015, 36(3):1604 e7-16. 

(9)Bi R, Zhao L, Zhang C, Lu W, Feng JQ, Wang Y, Ni J, Zhang J, Li GD, Hu QX, Wang D, Yao YG*, Li T*, No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals, Neurobiol Aging, 2014, 35(2):444 e5-9. 

(10)Bi R, Zhang AM, Jia X, Zhang Q, Yao YG*, Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G>A and Leber hereditary optic neuropathy, Mol Vis, 2012, 18:3087-3094. 

(11)Bi R, Zhang AM, Yao YG*, Leber's hereditary optic neuropathy, Ophthalmology, 2011, 118(7):1489-1489 e1481. 

(12)Bi R^#, Li WL^#, Chen MQ, Zhu Z, Yao YG*, Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny, Mutat Res, 2011, 709-710:15-20. 

(13)Bi R, Zhang AM, Zhang W, Kong QP, Wu BL, Yang XH, Wang D, Zou Y, Zhang YP, Yao YG*, The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells, Hum Mutat, 2010, 31(5):538-543. 

(14)Bi R, Zhang AM, Yu D, Chen D, Yao YG*, Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR, Clin Chim Acta, 2010, 411(21-22):1671-1674. 

(15)Xiang Q, Bi R*, Xu M, Zhang D-F, Tan L, Zhang C, Fang Y, Yao Y-G*, Rare genetic variants of the transthyretin gene are associated with Alzheimer’s disease in Han Chinese, Mol Neurobiol, 2017, 54: 5192-5200. 

(16)Guo L, Yuan Y, Bi R*, Mitochondrial DNA mutation m.5512A > G in the acceptor-stem of mitochondrial tRNATrp causing maternally inherited essential hypertension, Biochem Biophys Res Commun, 2016, 479: 800-807. 

2.参予撰写书中章节 

Bi R, Logan I, Yao Y-G*. 2016. Leber hereditary optic neuropathy: a mitochondrial disease unique in many ways. In: H. Singh, S.-S. Sheu. (eds). Pharmacology of Mitochondria. Handbook of Experimental Pharmacology, 240:309-336