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赵旭东  研究员
肿瘤干细胞生物学学科组
职  务: PI;中科院昆明灵长类研究中心主任
学  历: 博士
电  话: +86 871 68125430
传  真:
电子邮件: zhaoxudong@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号中国科学院昆明动物研究所    650223
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  简  历

博士,研究员。中科院昆明动物研究所动物模型与人类疾病机理重点实验室”PI,肿瘤干细胞生物学学科组负责人,中科院昆明灵长类研究中心主任。2013年入选云南省高端科技人才引进计划,从事肿瘤干细胞、动物模型等相关研究,已在Nature Cell BiologyDevelopmental CellJCICancer ResearcOncogene等刊物发表论文30余篇。

2011.03 至今     中科院昆明动物研究所,肿瘤干细胞生物学学科组,研究员

2005.11—2011.03 美国哥伦比亚大学癌症遗传学研究所,博士后, Associate Research Scientist

2003.07—2005.10 上海南方模式生物中心,助理研究员、副研究员

2000.09—2003.07 上海第二医科大学 (现上海交通大学医学院),获博士学位

1997.09—2000.08 重庆医科大学第一附属医院消化疾病实验室,研究实习员、助理研究员

1994.09—1997.08 中国科学院昆明动物研究所,获硕士学位

1990.09—1994.07 西南师范大学(现西南大学)生物系,获学士学位

  研究方向

实验室主要在肿瘤干细胞和动物模型平台上研究癌症发病机理和药物研发,以及抗衰老药物及生物技术研发等。主要研究方向:

1. 抗肿瘤干细胞药物发现;

2. 抗衰老药物发现及生物技术;

3. 创新动物模型的建立,特别是灵长类肿瘤模型建立及其应用;

4. 肿瘤免疫和免疫治疗。

  

  承担科研项目

1. 国家基金委-云南省联合基金“胰腺癌灵长类模型建立及其在循环肿瘤细胞研究中的应用” (204万)

2. 国家自然科学基金面上项目基于胶质母细胞瘤干细胞的高通量抗肿瘤药物筛选技术的建立和应用80万元)

3. 国家自然科学基金面上项目“HUWE1在卵巢癌发生发展中的作用60万元)

4. 中科院干细胞与再生医学研究先导科技专项子课题 (600万元)

5. 云南省高端科技人才引进计划癌症干细胞特异性分子标记发掘和药物筛选200万元)

6.中国科学院战略生物资源科技服务网络计划模式与特色动物实验平台野生动物实验动物化项目“树鼩实验动物化研究”(90万元)

  专家类别
研究员
  社会任职
  获奖及荣誉

(一)获奖

2005 云南省科学技术奖二等奖(自然科学类);获奖名称:两性生殖道内抗原特异性抗体和抗体分泌细胞的功能、来源和性激素的调控。获奖人员:贲昆龙、曹筱梅、王玉奇、王晓蕾、陈云亮、俞明灿、王云美、赵旭东。

(二)专利

1. 赵旭东、杨东、代智、王路.一种抗肿瘤药物筛选细胞模型及其应用(专利号:201410381401.6

2. 赵旭东、涂秋. 一种建立胰腺癌模型的方法.(申请号:201510531787.9)

3. 严兰珍、赵旭东、涂秋、孙彬. 一种曲细精管支持细胞转基因非人灵长类动物模型及其用途(申请号:201611187895.X

4. 赵旭东、涂秋. 一种用慢病毒在野生型成体小鼠中建立胰腺癌模型的方法.(申请号:201710718479.6 )

  代表论著

(*共同第一作者,# 共同通讯作者)

1.      Zhou X, Li G, An S,…, Iavarone A#, Zhao X#. A new method of identifying glioblastoma subtypes and creation of corresponding animal models. Oncogene. (Accepted)

2.      Yang D*, Cheng D*, Tu Q*,…, Yu X#, Jiang H#, Zhao X#. The HUWE1-p53 axis Controls the Development of Non-Small Cell Lung Cancer. Theranostics. (Accepted)

3.      Li C, Yan L, Ban W, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma Y, Nie W, Lv L, Yao Y#, Zhao X#, Zheng P#. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Res. 2017; 27(2):241-252.

4.      Yang D, Sun B, Zhang X, Cheng D, Yu X, Yan L, li L, An S, Jiang H, Lasorella A, Iavarone A, Zhang S, Zou F#, Zhao X#. Huwe1 sustains normal ovarian epithelial cell transformation and tumor growth through the histone H1.3-H19 cascade. Cancer Res 2017; 77(18):4773-4784.

5.      Tu Q*, Hao J*, Zhou X*, Yan L, Dai H, Sun B, Yang D, An S, Lv L, Jiao B, Chen C, Lai R, Shi P#, Zhao X#. CDNK2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletin due to juxtposition to CDKN2A. Oncogene 2018; 37(1):128-138.

6.      Tong Y*, Hao J*, Tu Q*, Yu H, Yan L, Li Y, Lv L, Wang F, Iavarone A, Zhao X. A tree shrew glioblastoma model recapitulates features of human glioblastoma. Oncotarget. 2017; 8:17897-19072.

7.      Li YZhao YZhou XNi WDai ZYang DHao JLuo LLiu YLuo X#Zhao X#. Cytotoxic indole alkaloid 3a-acetonyltabersonine glioblastoma apoptosis via inhibition of DNA damage repair. Toxins. 2017; 9(5):150-167.

8.      Liu T*, Guo Y*, Yan L, Sun B, Zheng P, Zhao X. Depletion of endogenous germ cells in tree shrews in preparation for spermatogonial transplantation. Exp Ther Med. 2017; 14(3):2349-2354

9.      Dai Z, Li S, Zhu P, Liu L , Wang B, Liu Y, Luo X#, Zhao X #. Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis. Bioorg Med Chem Let. 2017; 27(13):2863-2867

10. Wei X, Dai Z, Yang J, Khanc A, Yu HF, ZhaoYL, Wang YF, Liu YP, Yang ZF, Huang WY, Wang XH#, Zhao X#, Luo XD#. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells. Bioorg Med Chem 201826(8):1776-83

11. Yan L, Sun B, Lv L, Ma Y, Chen J, Lin Q, Zheng P, Zhao X. Early embryonic development and transplantation in tree shrews. Dongwuxue Yanjiu. 2016; 37(4): 252-258.

12. Niola F*, Zhao X*, Singh D, Sullivan R, Castano A, Verrico A, Zoppoli P, Friedmann-Morvinski D, Sulman E, Barrett L, Zhuang Y, Verma I, Benezra R, Aldape K, Iavarone A, Lasorella A . Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. J Clin Invest, 2013;123(1):405–417.

13. Niola F*, Zhao X*, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A.Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nat Cell Biol, 2012;14(5):477-487. (* equal contribution)

14. Zhao X*, D’Arca D*, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, and Lasorella A. the N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell, 2009;17(2): 210-221. (Cover article)

15. Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A. The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol, 2008;10(6): 643-653.

16. Liu X*, Zhao X*, Wang X*, Yao Y, Zhang L,Shu R, Ren W, Huang Y, Huang L, Gu M, Kuang Y, Wang L, Lu S, Chi J, Fen J, Wang Y, Fei J, Dai W, Wang Z. Germinal cell aplasia in Kif18a mutant male mice due to impaired chromosome congression and dysregulated BubR1 and CENP-E. Genes Cancer, 2010; 1(1): 26–39. (Cover article)

17. Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z. Wnt pathway is involved in tumorigenesis of pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. Int J Cancer, 2006; 118(3): 643-648.

18. Zhao X, Dang S, Liang B, Lei X, Chen Z, Wang L, Yan L, Sun H, Fu J, Fei J, Wang Z. PCR-based approaches for identification of multi-copy transgene integration sites in mouse genome. Chin Sci Bull, 2006; 51(18): 2231-2235.

19. Wang X*, Zhao X*, Ben K, Cao X, Wang Y, Zhou H. Circulating immunoglobulin A- and immunoglobulin G-secreting hybridoma cells in peripheral blood preferably migrate to female genital tracts. The role of sex hormones. Immunology. 2002 Jul;106(3):343-53.

20. Zhao X, Yang WJ, Wang L, Kong H, Ren WH, Zhang M, Fei J, Zhang CP, Wang ZG. Development of salivary gland tumors in pleomorphic adenoma gene 1 transgenic mice. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003; 20(5):390-5. Chinese.

21. Xu J, Yu M, Peng C, Carter P, Tian J, Ning X, Zhou Q, Tu Q, Zhang G, Dao A, Jiang X, Kapur P, Hsieh JT, Zhao X, Liu P, Zheng J. Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates. Angew Chem Int Ed Engl. 2018;57(1):266-271.

22. Zhu P, Dai Z, Wang B, Wei X, Yu H, Yan Z, Zhao X, Liu Y, Luo X. The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum. Nat Prod Bioprospect. 2017; 7(4):323-327.

23. Zhu PF, Dai Z, Wang B, Wei X, Yu HF, Yan ZR, Zhao XD, Liu YP, Luo XD. The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum. Nat Prod Bioprospect. 2017; 7(6):421-431.

24. Fan Y, Huang Z, Cao C, Chen C, Chen Y, Fan D, He J, Hou H, Hu L, Hu X, Jiang X, Lai R, Lang Y, Liang B, Liao S, Mu D, Ma Y, Niu Y, Sun X, Xia J, Xiao J, Xiong Z, Xu L, Yang L, Zhang Y, Zhao W, Zhao X, Zheng Y, Zhou J, Zhu Y, Zhang G, Wang J, Yao Y. Genome of the Chinese tree shrew. Nat Commun, 2013;4:1426-1434.

25. Jones-Mason ME, Zhao X, Kappes D, Lasorella A, Iavarone A, Zhuang YE. protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity, 2012; 36(3):348-361.

26. D’Arca D, Zhao X, Xu W, Ramirez-Martinez NC, Iavarone A, Lasorella A. The Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. Proc Natl Acad Sci USA, 2010; 107: 5875-5880.

27. Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A.The transcriptional network for mesenchymal transformation of brain tumours. Nature, 2010; 463(7279):318-325.

28. Gan Y, Zhao X, Hu J, Wang ZG and Zhao XT. HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality. Cell Death and Diff, 2008; 15 (9): 1481–1490.

29. Rothschild G, Zhao X, Iavarone A, Lasorella A. E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. Mol Cell Biol, 2006; 26(11): 4351-4361.

  研究团队

工作人员:

严兰珍 高级实验师 yanlanzhen@mail.kiz.ac.cn

孙彬 助理研究员 sunbin@mail.kiz.ac.cn

杨东 助理研究员  yangdong@mail.kiz.ac.cn

戴红娟 助理研究员 daihongjaun@mail.kiz.ac.cn

涂秋 博士后 tuqiu@mail.kiz.ac.cn

周霞 博士后 zhouxia@mail.kiz.ac.cn

研究生:

智;李仕容;张现宁;贾昕彤;崔潇月;祁士钢;刘秀云;齐华新;陈新茹;李国蒙;王恩娜;刘昱辰

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