专家人才库数据----中国科学院昆明动物研究所

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曾健雄研究员

神经病毒感染与疾病学科组

职　　务：

学　　历：

电　　话：

传　　真：

电子邮件：

zengjianxiong@mail.kiz.ac.cn

通讯地址：

云南省昆明市盘龙区茨坝街道龙欣路17号 503室 650201

其他主页：

简　　历

博士，研究员。2015年毕业于中国农业科学院哈尔滨兽医研究所获博士学位，同年赴南加州大学凯克医学院从事博士后研究工作，主要研究方向是嗜神经病毒的致病机制和抗感染免疫，相关研究成果发表在Cell Stem Cell、Nature Microbiology、Cell Reports、Journal of Virology、Antiviral Research、Journal of Neuroinflammation等刊物。2021年引进到中科院昆明动物所，建立神经病毒感染与疾病学科组。

研究方向

重大病毒性全球流行对公共卫生安全造成巨大挑战，2015-2016全球爆发与流行的寨卡病毒仅在巴西就造成几千例胎儿小头症，2019年底突发的新冠疫情已经造成全球范围流行。其中，众多人类重要（突发）病毒都不同程度表现出嗜神经感染能力，研究其致病机制以及与神经退行性疾病发生的关联机制具有重要意义。基于云南和研究所的动物资源，课题组以病毒与神经学科交叉为特色开展如下研究：

1、利用神经（干）细胞培养/分化和小鼠模型解析病毒嗜神经感染导致神经发育或功能异常的表型和机制；

2、利用细胞（iPSC诱导的类脑器官、神经细胞）和动物（小鼠、树鼩、非人灵长类猕猴）模型、高等级生物安全P3实验室（灵长类）研究重要（突发）病毒的致病机制和抗病毒药物或疫苗的评价；

3、利用动物模型（小鼠、树鼩）研究病毒嗜神经感染和其引发的神经免疫/炎症促发神经退行性疾病的分子机制和潜在药物靶点。

承担科研项目

专家类别

研究员

社会任职

获奖及荣誉

代表论著

[1] Jianxiong Zeng^#, Zhifei Luo^#, Shupeng Dong, Xiaochu Xie, Xinyan liang, Youzhen Yan, Qiming Liang, Zhen Zhao^*. Functional mapping of AGO-associate zika virus-derived small interfering RNAs in neural stem cells. Front. Cell. Infect. Microbiol. 2021, 11:628887.

[2] Haijian Wu^#, Jingwei Zheng^#, Shenbin Xu, Yuanjian Fang, Yingxi Wu, Jianxiong Zeng, Anwen Shao, Ligen Shi, Jianan Lu, Shuhao Mei, Xiaoyu Wang, Xinying Guo, Yirong Wang, Zhen Zhao^*, Jianmin Zhang^*. Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury. Journal of Neuroinflammation. 2021, 18:2.

[3] Jianxiong Zeng^#, Shupeng Dong^#, Zhifei Luo^#, Xiaochun Xie^#, Bishi Fu^#, Ping Li^#, Chengrong Liu^#, Xing Yang, Yujie Chen, Xin Wang, Zhenshan Liu, Jing Wu, Jian-Fu Chen, Jian Zhang, Gang Long, Steven A. Goldman, Shitao Li^*, Zhen Zhao^*, Qiming Liang^*. The zika virus capsid disrupts corticogenesis by suppressing dicer activity and miRNA biogenesis. Cell Stem Cell. 2020, 27:1-15.

[4] Jianxiong Zeng^#, Yaoming Wang^#, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yan, Younho Choi, Xiaochu Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav V. Zlokovic^*, Zhen Zhao^*, Jae U. Jung^*. TRIM9-mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice. Cell Reports. 2019, 27(2):549-560.

[5] Su-Jin Park^#, Young-II Kim^#, Angela Park, Hyeok-II Kwon, Eun-Ha Kim, Young-Jae Si, Min-Suk Song, Chul-Ho Lee, Kyle Jung, Woo-Jin Shin, Jianxiong Zeng, Younho Choi, Jae U. Jung^*, Young Ki Choi^*. Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis. Nature Microbiology. 2019, 4(3):438.

[6] Qiming Liang^*, Zhifei Luo, Jianxiong Zeng, Weiqiang Chen, Suan-Sin Foo, Shin-Ae Lee, Jianning Ge, Su Wang, Steven A. Goldman, Berislav V. Zlokovic, Zhen Zhao^*, Jae U. Jung^*. Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy. Cell Stem Cell. 2016 19(5):663-671.

[7] Jianxiong Zeng^#, Haiwei Wan^#, Xiaochun Xie, Chen Li, Guohui Zhou, Decheng Yang, Li Yu^*. Ribavirin-resistant variants of foot-and-mouth disease virus: The effect of restricted quasispecies diversity on viral virulence. Journal of Virology. 2014, 88(8): 4008-4020.

[8] Jianxiong Zeng^#, Haiwei Wang^#, Xiaochun Xie, Chen Li, Decheng Yang, Guohui Zhou, Li Yu^*. An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo. Antiviral Research. 2013, 100:1-7.

[9] Xiaochun Xie^#, Haiwei Wang^#, Jianxiong Zeng, Chen Li, Guohui Zhou, Decheng Yang, Li Yu^*. Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated. Archives of virology. 2014, 159(10):2641-2650.

[10] Haiwei Wang, Shanshan Song, Jianxiong Zeng, Guohui Zhou, Decheng Yang, Te Liang, Li Yu^*. Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus. Virologica Sinica. 2014, 29(2):103-111.

研究团队

李晓红科研助理