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李明  研究员
转化基因组学科组
职  务: 转化基因组实验室负责人
学  历: 理学博士
电  话: +86 871 65190162
传  真: +86 871 65190162
电子邮件: limingkiz@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号 中国科学院昆明动物研究所    650223
其他主页: http://limingkiz.weebly.com/
  简  历

  研究员,博士生导师。2008年毕业于武汉大学生命科学学院获学士学位,2013年于中国科学院昆明动物研究所获得遗传学博士学位,同年8月赴约翰霍普金斯大学医学院Lieber脑发育研究所(Lieber Institute for Brain Development)从事博士后研究工作,2016年5月回昆明动物研究所工作。现为转化基因组学科组负责人。近年来已在Nature Medicine,American Journal of Psychiatry,Molecular Psychiatry,Schizophrenia Bulletin,British Journal of Psychiatry,Molecular Biology and Evolution,Genome Biology,BMC Biology,Translational Psychiatry和Schizophrenia Research等国内外著名期刊发表论文和评述40余篇。博士毕业论文获得2014年度中科院百篇优秀博士论文和云南省百篇优秀博士论文。荣获朱李月华奖学金(2011),院长优秀奖学金(2012),国家奖学金(2013),三好学生标兵称号(2011)及优秀博士毕业生(2013)等奖励。任《Scientific Reports》学术主编,受邀为超过20个SCI期刊审稿。 

  2004.09 - 2008.07   武汉大学生命科学学院,获学士学位 

  2008.09 – 2013.07中国科学院昆明动物研究所,获博士学位 

  2013.08 – 2016.09 Lieber脑发育研究所,博士后 

  2016.05 – 至今 研究员,博士生导师,中科院昆明动物研究所转化基因组学科组负责人。 

  研究方向

  实验室主要研究方向为DNA遗传变异如何通过改变易感基因的表达和功能从而影响大脑功能及精神疾病的发生;为了使我们的研究结果与临床实践紧密结合,我们还将研究精神疾病相关药物对易感基因的表达调控及作用机理,为精神疾病药物的改进及开发奠定理论基础,进而将我们的研究成果转化于临床应用。 

  承担科研项目
  专家类别
研究员
  社会任职
  获奖及荣誉
  代表论著

1.    Chang H,# Xiao X,# Li M.* The Schizophrenia Risk Gene ZNF804A: Clinical Associations, Biological Mechanisms and Neuronal Functions. Molecular Psychiatry 2017; 22:944-953.

2.    Chang H,# Hoshina N,# Zhang C,# Ma Y, Cao H, Wang Y, Wu DD, Bergen SE, Landén M, Hultman CM, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, N?then MM, The Swedish Bipolar Study Group, MooDS Bipolar Consortium, Walter H, Erk S, Heinz A, Amin N, van Duijn CM, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T,* Rietschel M,* Li M.* The Protocadherin 17 Gene Affects Cognition, Personality, Amygdala Structure and Function, Synapse Development and Risk of Major Mood Disorders. Molecular Psychiatry 2017 January 10. doi:10.1038/mp.2016.231.

3.    Chang H,# Li L,# Peng T,# Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, N?then MM, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M; Swedish Bipolar Study Group; MooDS Consortium, Xiao X,* Li M.* Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1. Molecular Neurobiology 2017; 54:5166-5176.

4.    Xiao X,# Luo XJ,# Chang H,# Liu Z, Li M.* Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses. Molecular Neurobiology 2017; 54:4071-4080.

5.   Chang H, Li L, Li M,* Xiao X.* Rare and common variants at 16p11.2 are associated with schizophrenia. Schizophrenia Research 2017; 184:105-108.

6.    Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR.* A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia associated locus. Nature Medicine 2016; 22:649-656.

7.    Li M,* Chang H, Xiao X. BDNF Val66Met Polymorphism and Bipolar Disorder in European Populations: A Risk Association in Case-Control, Family-based and GWAS Studies. Neuroscience and Biobehavioral Reviews 2016; 68:218-233.

8.    Li M,#,* Wu DD,# Yao YG, Huo YX, Liu JW, Su B, Chasman DI, Chu AY, Huang T, Qi L, Zheng Y, CHARGE Nutrition Working Group, DietGen Consortium, Luo XJ.#,* Recent positive selection drives the expansion of a schizophrenia risk non-synonymous variant at SLC39A8 in Europeans. Schizophrenia Bulletin 2016; 42:178-190.

9.    Li M,#,* Luo XJ,# Landén M, Bergen SE, Hultman CM, Li X, Zhang W, Yao YG, Zhang C, Liu J, Mattheisen M, Cichon S. Mühleisen TW, Degenhardt FA, N?then MM, Schulze TG, Grigoroiu-Serbanescu M, Li H, Fuller CK, Chen C, Dong Q, Chen C, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Preisig M, Kutalik Z, Castelao E, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, MooDS Consortium, The Swedish Bipolar Study Group, Rietschel M, Liu C, Kleinman JE, Hyde TM, Weinberger DR, Su B.*Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance. British Journal of Psychiatry 2016; 208:128-137.

10.     Li M,#,* Huang L,# Grigoroiu-Serbanescu M,* Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, N?then MM, Alkelai A, Lerer B, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M; MooDS Consortium; Swedish Bipolar Study Group. Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis. Molecular Neurobiology 2016; 53:6608-6619.

11.     Li M,# Luo XJ,# Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, N?then MM, Schulze TG, Sullivan PF, Bergen SE, Donohoe G, Morris DW, Hargreaves A, Gill M, Corvin A, Hultman C, Toga AW, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis JC, Ikram MA, Fornage M, Debette S, Launer LJ, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein JL, Medland SE, Vasquez AA, Hibar DP, Franke B, Martin NG, Wright MJ, MooDS Bipolar Consortium, The Swedish Bipolar Study Group, Alzheimer’ s Disease Neuroimaging Initiative, ENIGMA consortium, CHARGE consortium, Su B.* Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry 2014; 19:452-461.

12.     Luo XJ,#,Li M,# Huang L, Steinberg S, Mattheisen M, Liang G, Donohoe G, Shi Y, Chen C, Yue W, Alkelai A, Lerer B, Li Z, Yi Q, Rietschel M, Cichon S, Collier DA, Tosato S, Suvisaari J, Rujescu D, Golimbet V, Silagadze T, Durmishi N, Milovancevic MP, Stefansson H, Schulze TG, N?then MM, Chen C, Lyne R, Morris DW, Gill M, Corvin A, Zhang D, Dong Q, Moyzis RK, Stefansson K, Sigurdsson E, Hu F; MooDS SCZ Consortium, Su B, Gan L.* Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. Molecular Psychiatry 2014; 19:774-783.

13.     Li M, Ge T, Feng J, Su B.* SLC6A15 rs1545843 and depression: implications from brain imaging data. The American Journal of Psychiatry 2013; 170:805.

14.     Li M, Su B.* Meta-analysis supports association of a non-synonymous SNP in ZNF804A with schizophrenia. Schizophrenia Research 2013; 149:188-189.

15.     Li M,# Luo XJ,# Xiao X,# Shi L, Liu XY, Yin LD, Ma XY, Yang SY, Pu XF, Yu J, Diao HB, Shi H, Su B.* Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population. The World Journal of Biological Psychiatry 2013; 14:91-99.

16.     Li M,# Wang Y,# Zheng XB, Ikeda M, Iwata N, Luo XJ, Chong SA, Lee J, Rietschel M, Zhang FY, Müller-Myhsok B, Cichon S, Weinberger DR, Mattheisen M, Schulze TG, Martin NG, Mitchell PB, Schofield PR, Liu JJ, Su B,* MooDS Consortium. Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. Schizophrenia Research 2012; 142:200-205.

17.     Li M, Luo XJ, Xiao X, Shi L, Liu XY, Yin LD, Diao HB, Su B.* Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia. The American Journal of Psychiatry 2011; 168:1318-1325.

18.     Li M,# Luo XJ, Zhang X, Yang ZH, Xiang K, Xiao X, Su B,* Zhao YL,# Shen Y, Xu Q,* Chen XN, Chen JC, Liu XY, Yin LD, Ma XY, Yang SY, Yu J, Diao HB, Shi XD. A common variant of the cardiomyopathy associated 5 gene (CMYA5) is associated with schizophrenia in Chinese population.Schizophrenia Research 2011; 129:217-219.

19.     Li M,# Mo Y,# Luo XJ,# Xiao X,# Shi L, Peng YM, Qi XB, Liu XY, Yin LD, Diao HB, Su B.* Genetic association and identification of a functional SNP at GSK3beta for schizophrenia susceptibility. Schizophrenia Research 2011; 133:165-171.

  研究团队

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