专家人才     首页 > 研究队伍
齐晓朋  研究员
病原菌感染与宿主免疫机制学科组
职  务:
学  历: 理学博士
电  话: +86 871 65110289
传  真: +86 871 65110289
电子邮件: qixiaopeng@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号 中国科学院昆明动物研究所    650223
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  简  历

主要从事免疫细胞的增殖、分化以及宿主抵抗病原微生物侵染的免疫机制研究。

2016.03 中国科学院昆明动物研究所, 研究员

2014.012016.02美国圣犹大儿童研究医院(St. Jude Children’s Research Hospital),博士后

2010.062013.12 美国犹太医学中心(National Jewish Health), 博士后

2009.012010.05 美国印第安纳大学(Indiana University),博士后

2007.102008.12 美国德州理工大学(Texas Tech University),博士后  

2006.072007.10 浙江省农科院,助理研究员

2001.092006.07 浙江大学,遗传学专业获博士学位  

1997.092001.07聊城大学,生物教育专业获学士学位     

  研究方向

实验室主要研究病原体感染诱导的宿主免疫激活和免疫细胞的发育、分化调控机制,以及慢性炎症疾病发生的内在机理。具体包括以下方面内容:

a. 耐药性胞外菌和高致病性胞内菌的感染致病机理;

b. 蚊媒介导的病毒感染、传播机制;

c. 过敏及环境污染等因素导致的慢性炎症疾病;

d. 过敏及环境因素导致的病原体易感机制研究。

  承担科研项目

国家重点研发计划重点专项畜禽重要胞内菌基因调控及其与宿主互作的分子机制研究项目,2017-2020,课题三负责人。

  专家类别
研究员
  社会任职
  获奖及荣誉
  代表论著

1.     Fubing Li*, Yang Li*, Huichun Liang*, Tao Xu*, Yanjie Kong, Maobo Huang, Ji Xiao, Xi Chen, Houjun Xia, Yingying Wu, Zhongmei Zhou, Xiaomin Guo, Chunmiao Hu, Chuanyu Yang, Xu Cheng, Ceshi Chen#, and Xiaopeng Qi#. 2018. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. Journal of Clinical Investigation, doi:10.1172/JCI120406 (IF: 13.251)

2.     Lin Jin*, Xiaomin Guo*, Chuanbin Shen*, Xue Hao*, Peng Sun*, Pengpeng Li, Tao XuChunmiao Hu, Ombati Rose, Hongning Zhou, Mingdong Yang, Cheng-Feng Qin, Jingya Guo, Hua Peng, Mingzhao Zhu, Gong Cheng#, Xiaopeng Qi#, and Ren Lai#. 2018. Salivary factor LTRIN from Aedes aegypti facilitates Zika virus transmission by interfering with the lymphotoxin-b receptor. Nature Immunology, 19: 342–353. (IF: 21.809)

3.     Yang Li*, Xiaomin Guo*, Chunmiao Hu, Yan Du, Chuansheng Guo, Di Wang, Weiheng Zhao, Gonghua Huang, Chunliang Li, Qiumin Lu, Ren Lai, Tao Xu, and Xiaopeng Qi#. 2018. Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death & Differentiation, doi:10.1038/s41418-017-0041-z (IF: 8.339)

4.     Yan-Hu Liu*, Lu Wang*, Tao Xu*Xiaomin Guo, Yang Li, Ting-Ting Yin, He-Chuan Yang, Yang Hu, Adeniyi C. Adeola, Oscar J. Sanke, Newton O. Otecko, Meng Wang, Yaping Ma, Olaogun S. Charles, Mikkel-Holger S. Sinding, Shyam Gopalakrishnan, José Alfredo Samaniego, Anders J. Hansen, Carlos Fernandes, Philippe Gaubert, Jane Budd, Philip M. Dawuda, Lubin Jiang, M.T.P Gilbert, Weiwei Zhai, Xiaopeng Qi#, Guo-Dong Wang#, Ya-Ping Zhang#. 2018. Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites. Molecular Biology and Evolution, 35(2): 287-298. (IF: 10.217)

5.     Qiang Shao, Stephanie Herrlinger, Ya-Nan Zhu, Mei Yang, Forrest Goodfellow, Steven L. Stice, Xiaopeng Qi, Melinda A. Brindley, Jian-Fu Chen. 2017. The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus. Development, 144(22): 4114-4124. (IF: 6.059)

6.     Xiaopeng Qi#. 2016. Formation of membrane pores by gasdermin-N causes pyroptosis.  Sci China-Life Sci, 07.26, 59(10): 1071-1073. (IF: 3.085)

7.     Xiaopeng Qi, Si Ming Man, R K Subbarao Malireddi, Rajendra Karki, Christopher Lupfer, Prajwal Gurung, Geoffrey Neale, Clifford Guy, Mohamed Lamkanfi, Thirumala-Devi Kanneganti. 2016. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. The Journal of Experimental Medicine, 213(10): 2081-97. (IF: 13.912)

8.     Rajendra Karki,Si Ming Man, Subbarao Malireddi,Sannula Kesavardhana, Qifan Zhu, Amanda R. Burton,Bhesh Raj Sharma, Xiaopeng Qi, Stephane Pelletier, Peter Vogel, Philip Rosenstiel    & Thirumala-Devi Kanneganti. 2016. NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer. Nature, 540: 583–587. (IF: 38.138)

9.     Xiaopeng Qi, Prajwal Gurung, R. K. Subbarao Malireddi, Peer W. F.  Karmaus, Deepika Sharma, Peter Vogel, Hongbo Chi, Douglas R. Green and Thirumala-Devi Kanneganti. 2016. Critical role of caspase-8–mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunology, 10(1): 128-138. (IF: 7.374)

10.  Yapeng Li, Xiaopeng Qi, Bing Liu, Hua Huang. 2015. The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance. The Journal of Immunology, 194(9): 4328-38. (IF: 4.92)

11.  Xiaopeng Qi, Jessie Hong, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chabon, Brian Graham, Keitaro Ohmori, Yapeng Li, and Hua Huang. 2013. Antagonistic regulation by the transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 39 (1): 97-110. (IF: 24.082)

12.  Zhihong Chen, Shanze Wang, Nkiruka Erekosima, Yapeng Li, Jessie Hong, Xiaopeng Qi, Patricia Merkel, Vijaya Nagabhushanam, Eugene Choo, Rohit Katial, Rafeul Alam, Anita Trikha, HongWei Chu, Yonghua Zhuang, Meiling Jin, Chunxue Bai, and Hua Huang. 2013. IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing STAT1 signaling. The Journal of Allergy and Clinical Immunology, 132 (4): 912-921. (IF: 13.258)

13.  Xiaopeng Qi, Jun Nishida, Lee Chaves, Keitaro Ohmori and Hua Huang. 2011. C/EBPα is critical for interleukin-4 expression in response to FcεR1 receptor cross-linking. The Journal of Biological Chemistry, 286 (18): 16063-16073.

14.  Xiaopeng Qi, Tyler Droste and Cheng Kao. 2011. Cell-Penetrating Peptides Derived from Viral Capsid Proteins. Molecular Plant-Microbe Interactions. 24 (1): 25-36.

15.  Xiaopeng Qi, Forrest Sheng Bao and Zhixin Xie. 2009. Small RNA Deep Sequencing Reveals Role for Arabidopsis thaliana RNA-dependent RNA polymerases in Viral siRNA Biogenesis. PLoS one, 4 (3):e4971.

16.  Xiaopeng Qi, Zhongchang Wu, Jinhui Li, Xiaorong Mo, Shihua Wu, Jun Chu, Ping Wu. 2007. AtCYT-INV1, a neutral invertase, is involved in osmotic stress-induced inhibition on lateral root growth in Arabidopsis. Plant Molecular Biology, 64: 575-587.

  研究团队

研究工作人员:

徐涛,冷小鹏,李杨,郭晓敏,王欢,王朝明,郭宇,董锭

研究生: 在招,欢迎有兴趣的同学随时来信咨询实验室的硕士生、博士生、博士后、助理研究员等位置的相关信息!

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