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焦保卫  研究员
表观遗传与发育调控学科组
职  务: 表观遗传与发育调控研究组 负责人
学  历:
电  话: +86 871 65191706
传  真:
电子邮件: jiaobaowei@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号    650223
其他主页: http://imprinting.kiz.ac.cn
  简  历

2013.04—      中国科学院昆明动物研究所 研究员  

2008.10—2013.04  马萨诸塞大学医学院 博士后 

2007.05—2008.10  香港中文大学中医学院任研究助理 

2003.09—2007.03  香港中文大学生化系环境科学哲学博士 

2000.09—2003.07  西南大学生命科学学院动物学专业理学硕士 

1996.09—2000.07  西南大学生命科学学院理学学士
  研究方向

乳腺发育、乳腺癌、乳腺(癌)干细胞

  

  承担科研项目

2013  国家自然科学基金面上项目   

2014  中国科学院先导专项课题  

        云南省高端科技人才引进项目 

2016  干细胞及转化研究国家重点研发计划项目

2018  国家自然科学基金-云南联合基金

  专家类别
研究员
  社会任职

云南省细胞生物学学会第五届理事会秘书长

  获奖及荣誉
  代表论著

1. Wang S#, Ke H#, Zhang H, Ma Y, Ao L, Zou L, Yang Q, Zhu H, Nie J*, Wu C*, Jiao B*. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death and Disease. 2018 Jul 24;9(8):805. 

2. Chen W#, Wang H#, Cheng M#, Ni L, Zou L, Yang Q, Cai X*, Jiao B*. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Biomedicine & Pharmacotherapy. 2018 Jul;103:435-442

3. Ke H#, Zhao L#, Zhang H#, Feng X, Xu H, Hao J, Wang S, Yang Q, Zou L, Su X, Wang L, Wu C, Wang Y, Nie J, Jiao B*. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3.Proceedings of the National Academy of Sciences of U S A. http://www.pnas.org/content/early/2018/03/21/1714573115 

4. Zhang H#, Yang X#, Feng X, Xu H, Yang Q, Zou L, Yan M, Liu D, Su X, Jiao B*. Chromosome-wide gene dosage rebalance may benefit tumor progression. Molecular Genetics and Genomics. 2018 Mar 15. https://link.springer.com/article/10.1007/s00438-018-1429-2

5. Lv C, Li F, Li X, Tian Y, Zhang Y, Sheng X, Song Y, Meng Q, Yuan S, Luan L, Andl T, Feng X, Jiao B, Xu M, Plikus MV, Dai X, Lengner C, Cui W, Ren F, Shuai J, Millar SE, Yu Z*. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications. 2017, 8(1):1036. doi: 10.1038/s41467-017-01059-5.

6. Yang X#, Wang H*, Jiao B*. Mammary gland stem cells and their application in breast cancer. Oncotarget. 2017;8(6):10675-91.

7. Ke H#, Zhao L#, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L, Jiao B*. NEAT1 is required for survival of breast cancer cells through FUS and miR-548. Gene Regulation and Systems Biology,2016,10(Suppl 1):11-7.

8. Wu Y#, Feng X#, Gao L*Jiao B*. Imprinted genes: important regulators in development.Hereditas(Beijing). 2016,38(6):508-522.

9. Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones S, Mager JBach I*. 2013.  Rnf12/RLIM is dispensable for X chromosome inactivation in the mouse embryonic epiblast. Nature2014,511(7507):86-9.  

10. Jiao B#, Taniguchi-Ishigaki N#, Güngr C#, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA#*, Bach I*. 2013. Nucleo-cytoplasmic shuttling regulates functional activity of Rnf12/RLIM. Molecular Biology of the Cell, 24(19):3085-96.

11. Jiao B, Ma H, Shokhirev M, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach Ihttp://10.20.40.10/wcm/app/editor/editor/images/spacer.gif*. 2012. http://10.20.40.10/wcm/app/editor/editor/images/spacer.gifPaternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell, 149:630-41.

12. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I*. 2010.  http://10.20.40.10/wcm/app/editor/editor/images/spacer.gifMaternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature, 467:977-81.   

13. Lin ZX*, Jiao B, Che CT, Zuo Z, Mok CF, Zhao M, Ho WK, Tse WP, Lam KY, Fan RQ, Yang ZJ, Cheng CH*. 2010. Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment. Phytotherapy Research, 24:1056-64.  

14. Jiao B, Yeung EKC, Chan CB, Cheng CHK*. 2008. Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green. Journal of Cellular Biochemistry,105:1399-409.   

15. Jiao B, Cheng CHK*. 2010. Disrupting actions of bisphenol A and malachite green on growth hormone receptor gene expression and signal transduction in seabream. Fish Physiology and Biochemistry, 36:251-61.

16. Wang DS#*, Jiao B#, Hu C, Huang X, Liu Z, Cheng CHK*. 2008. Discovery of a gonad-specific IGF subtype in teleost, Biochemical and Biophysical Research Communications, 367, 336-41.   

17. Huang X#, Jiao B#, Fung KK#, Zhang Y#, Chan CB, Lin H, Wang DS, Cheng CHK*. 2007. The presence of two distinct prolactin receptors with different signal pathways and constructive expression pattern under the stimulation of steroid hormones in teleost. Journal of Endocrinology, 194, 373-92.   

18. Liu Z#, Wu F#, Jiao B#, Zhang X, Hu C, Huang B, Zhou L, Huang X, Wang Z, Zhang Y, Nagahama Y, Cheng CHK*, Wang DS*. 2007. Molecular cloning of Dmrt1, Foxl2 and Cyp19 in Southern catfish and their possible roles in sex differentiation. Journal of Endocrinology, 194, 223-41.   

19. Jiao B#, Huang X#, Chan CB#, Zhang L#, Wang DS#, Cheng CHK*. 2006. The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology, 36, 23-40. 

  研究团队

工作人员:

王    慧    助理研究员 wanghui1@mail.kiz.ac.cn

张洪磊    助理研究员 hlzhang2014@163.com

柯    浩    助理研究员 kehao@mail.kiz.ac.cn

邹    丽    实    验    师 zouli@mail.kiz.ac.cn

研究生:

赵丽娜、徐海波、赵丽敏、杨星、郭璐、李玲玲、成美、杨旭、习显红

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