研究队伍
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百千万人才
杰出青年科学基金
优秀青年科学基金
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中青年科技创新领军人才
云南省高层人才
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研究队伍 -- 疾病机理遗传学与进化医学研究组
  姚永刚    研究员
职  务: 昆明动物研究所所长
学  历:
电  话: +86 871 65180085;68125440
传  真: +86 871 65180085
电子邮件: yaoyg@mail.kiz.ac.cn
通讯地址: 云南省昆明市教场东路32号 中国科学院昆明动物研究所 动物模型与人类疾病机理重点实验室    650223
其他主页: http://mitotool.kiz.ac.cn/lab/index.html
 
  简  历

姚永刚,博士,研究员,博士生导师。1997年毕业于安徽师范大学生物系获学士学位,2003年于中国科学院昆明动物研究所获得理学博士学位,同年2月后赴约翰霍普金斯大学医学院 (The Johns Hopkins University School of Medicine) 从事博士后研究工作,200410月转至美国国家健康研究院心脏、肺、血液研究所(National Heart, Lung, and Blood Institute, National Institutes of Health)学习和工作,200712回昆明动物研究所工作。现为疾病机理遗传学与进化医学学科组负责人。目前已在Am J Hum GenetAutophagyPNASAlzheimers DementNat CommunSCI期刊发表论文和评述200余篇,被SCI引用5170多次,h指数=38。先后获得国家自然科学奖二等奖(第二获奖人)、新世纪百千万人才工程国家级人选、云南省有突出贡献优秀专业技术人才奖、朱李月华优秀教师奖等奖项与荣誉称号。2009年获得国家杰出青年基金和云南省高端科技人才计划资助,先后承担中科院战略性科技专项(B类)(子课题负责人)、973计划(课题负责人)、基金委重点和面上项目等。现担任“Journal of Genetics and Genomics” Editorial Board Member (2010- ), “Journal of Human Genetics” Associate Editor (2011- ), “PLoS ONE” Academic Editor (2012- ), “Infection, Genetics and Evolution” Receiving Editor (2012- ), “Scientific Reports” Editorial Board Member (2016- ), “Journal of Alzheimer’s Disease” Associate Editor (2018- ), “Zoological Research” Associate editor (2010.12 – 2012.08) and Editor-in-chief (2012.09- )

  2014.07 -   中国科学院昆明动物研究所所长  

  2012.04 - 2014.07  中国科学院昆明动物研究所副所长(主持工作)  

  2010.04 - 2012.03  中国科学院昆明动物研究所所长助理  

  2007.12 - 至今  中国科学院昆明动物研究所,疾病机理遗传学与进化医学研究组学科带头人  

  2004.10 - 2008.01  美国国家健康研究院心脏、肺、血液研究所(National Heart, Lung, and Blood Institute, National Institutes of Health)Visiting Fellow  

  2003.02 - 2004.09  约翰霍普金斯大学医学院 (The Johns Hopkins University School of Medicine) 从事博士后研究工作  

  1997.09 - 2003.02  中国科学院昆明动物研究所,获博士学位 

  2001.05 - 2001.08  德国汉堡大学从事合作研究  

  1997.09 - 1998.07  中国科学院研究生院学习 

目前Yaolab开发的数据库:

AlzData: www.alzdata.org; Tree shrew database: www.treeshrewdb.org; Schizophrenia genetic research: www.szdb.org; mtDNA analysis: http://159.226.149.55/ or http://mitotool.kiz.ac.cn

  研究方向

致力于人类疾病机理的遗传机制与进化医学研究,按照EAF (E = Evolutionary analysis; A = Association study; F = Functional assay)三层次,带领团队深入开展神经和免疫系统相关疾病的遗传易感解析和机制研究,通过对阿尔茨海默症、精神分裂症、LHON等神经精神疾病以及感染性疾病麻风的遗传易感性解析,试图阐明机体神经系统与免疫系统紊乱和病变导致的复杂临床表型的遗传基础与机理。力争将复杂纷繁的科研工作变得“Easier And Fun”。同时,集中开展实验动物树鼩基础生物学和品系创制研究。

  承担科研项目

1)老年痴呆症、精神分裂症和麻风等疾病遗传易感与发病机制研究  

2)线粒体、自噬与疾病  

3)树鼩基础生物学

  专家类别
研究员;杰青;百千万人才
  社会任职
 
  获奖及荣誉

2014    云南省科学技术奖励二等奖(自然科学奖); 项目名称: Leber遗传性视神经病遗传易感分析; 获奖人员: 姚永刚、张阿梅、余丹丹、毕蕊. 

2012    中国科学院 朱李月华优秀教师奖 

2010    云南省有突出贡献优秀专业技术人才奖 二等奖 (一等奖空缺) 

2009    新世纪百千万人才工程国家级人选 

2006    国家自然科学奖二等奖; 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 获奖人员: 张亚平、姚永刚、孔庆鹏、丁远春、孙昌. 

2005    全国百篇优秀博士论文 

2002    中国科学院院长奖特别奖. 

  代表论著

 

1.      Bi R*, Zhang W, Zhang D-F, Xu M, Fan Y, Hu Q-X, Jiang H-Y, Tan L, Li T, Fang Y, Zhang C, Yao Y-G*. 2018. Genetic association of the cytochrome c oxidase-related genes with Alzheimer’s disease in Han Chinese. Neuropsychopharmacology, in press

2.      Ni H, Xu M, Zhan G-L, Fan Y, Zhou H, Jiang H-Y, Lu W-H, Tan L, Zhang D-F*, Yao Y-G*, Zhang C*. The GWAS risk genes for depression may be actively involved in Alzheimer’s disease. Journal of Alzheimer’s Disease, in press

3.      Li X, Luo Z, Gu C, Hall LS, McIntosh AM, Zeng Y, Porteous DJ, Hayward C, Li M, Yao Y-G, Zhang C, Luo X-J; 23andMe Research Team7. 2018. Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder. Neuropsychopharmacology, in press, doi: 10.1038/s41386-018-0078-9

4.      Wang D, Fan Y, Malhi M, Bi R, Wu Y, Xu M, Yu X-F, Long H, Li Y-Y, Zhang D-F*, Yao Y-G*. 2018. Missense variants in HIF1A and LACC1 contribute to leprosy risk in Han Chinese. American Journal of Human Genetics, 102: 794-805.

5.      Yang C-P, Li X, Wu Y, Shen Q, Zeng Y, Xiong Q, Wei M, Chen C, Liu J, Huo Y, Li K, Xue G, Yao Y-G, Zhang C, Li M, Chen Y, Luo X-J. 2018. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nature Communications, 9: 838.

6.      Fan Y, Luo R, Su L-Y, Xiang Q, Yu D, Xu L, Chen J-Q, Bi R, Wu D-D, Zheng P*, Yao Y-G*. 2018. Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer’s disease research? Journal of Alzheimer’s Disease, 61: 1015-1028 (doi: 10.3233/JAD-170594)

7.      Luo M-T, Fan Y, Mu D, Yao Y-G, Zheng Y-T. 2018. Molecular cloning and characterization of APOBEC3 family in tree shrew. Gene, 646: 143-152

8.      Peng M-S, Xu W, Song J-J, Chen X, Sulaiman X, Cai L, Liu H-Q, Wu S-F, Gao Y, Abdulloevich NT, Afanasevna ME, Ibrohimovich KB, Chen X, Yang W-K, Wu M, Li G-M, Yang X-Y, Rakha A, Yao Y-G, Upur H, Zhang Y-P. 2018. Mitochondrial genomes uncover the maternal history of the Pamir populations. European Journal of Human Genetics, 26:124-136 (doi: 10.1038/s41431-017-0028-8)

9.      Xiao X, Zhang C, Grigoroiu-Serbanescu M, Wang L, Li L, Zhou D, Yuan T-F, Wang C, Chang H, Wu Y, Li Y, Wu D-D, Yao Y-G, Li M. 2018. The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Molecular Psychiatry, doi: 10.1038/mp.2017.243.

10.    Zeng L, Ming C, Li Y, Su L-Y, Su Y-H, Otecko NO, Dalecky A, Donnellan S, Aplin K, Liu X-H, Song Y, Zhibin Z, Esmailizadeh A, Sohrabi SS, Nanaei HA, Liu H-Q, Wang M-S, Atteynine SA, Rocamora G, Brescia F, Morand S, Irwin DM, Peng M-S, Yao Y-G, Li H, Wu D-D, Zhang Y-P. 2018. Out of southern East Asia of the brown rat revealed by large scale genome sequencing. Molecular Biology and Evolution, 35: 149-158 (doi: 10.1093/molbev/msx276)

11.    Xiao X, Zheng F, Chang H, Ma Y, Yao Y-G, Luo X-J, Li M. 2018. The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder. Neuropsychopharmacology, 43: 1128-1137 (doi: 10.1038/npp.2017.241)

12.    Wang D*, Zhang D-F, Li GD, Bi R, Fan Y, Wu Y, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2018. A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China. British Journal of Dermatology, 178: 931-939.

13.    Xu M, Zhang D-F*, Luo R, Wu Y, Zhou H, Kong L-L, Bi R, Yao Y-G*. 2018. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease. Alzheimer’s & Dementia, 14: 215-229 (doi: 10.1016/j.jalz.2017.08.012)

14.    Bi R, Kong L-L, Xu M, Li G-D, Zhang D-F; Alzheimer’s Disease Neuroimaging Initiative., Li T, Fang Y, Zhang C, Zhang B, Yao Y-G*. 2018. The Arc gene confers genetic susceptibility to Alzheimer's disease in Han Chinese. Molecular Neurobiology, 55: 1217-1226 (doi: 10.1007/s12035-017-0397-6)

15.    Xiao X, Wang L, Wang C, Yuan T-F, Zhou D, Zheng F, Li L, Grigoroiu-Serbanescu M, Ikeda M, Iwata N, Takahashi A, Kamatani Y, Kubo M, Preisig M, Kutalik Z, Castelao E, Pistis G, Amin N, van Duijn CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, N?then MM, Chang H, Luo X-J, Fang Y, Yao Y-G, Zhang C, Rietschel M, Li M; Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium. 2017. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. Translational Psychiatry, 7: 1273.

16.    Zeng L, Ming C, Li Y, Su L-Y, Su Y-H, Otecko NO, Liu H-Q, Wang M-S, Yao Y-G, Li H-P, Wu D-D, Zhang Y-P. 2017. Rapid evolution of genes involved in learning and energy metabolism for domestication of the laboratory rat. Molecular Biology and Evolution, 34: 3148-3153 (doi: https://doi.org/10.1093/molbev/msx238)

17.    Wang D, Li G-D, Fan Y, Zhang D-F, Bi R, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2017. The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China. Journal of Dermatological Science, 88: 349-356 (doi: http://dx.doi.org/10.1016/j.jdermsci.2017.09.001)

18.    Zhang Y, Wu K, Su W, Zhang D-F, Wang P, Qiao X, Yao Q, Yuan Z, Yao Y-G, Liu G, Zhang C, Liu L, Chen C. 2017. Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα. Journal of Neuroscience, 37: 9741-9758 (doi: 10.1523/JNEUROSCI.0681-17.2017)

19.    Rakha A, Fatima, Peng M-S, Adan A, Bi R, Yasmin M, Yao Y-G. 2017. mtDNA sequence diversity of Hazara ethnic group from Pakistan. Forensic Science International: Genetics, 30: e1-e5 (doi: 10.1016/j.fsigen.2017.07.004)

20.    Su L-Y, Luo R, Liu Q, Su J-R, Yang L-X, Ding Y-Q, Xu L*, Yao Y-G*. 2017. Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine. Autophagy, 13: 1496-1511

21.    Tang J, Fan Y, Li H, Xiang Q, Zhang D-F, Li Z, He Y, Liao Y, Wang Y, He F, Zhang F, Shugart YY, Liu C, Tang Y*, Chan RCK*, Wang C-Y*, Yao Y-G*, Chen X*. 2017. Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. Journal of Genetics and Genomics, 44: 295-306

22.    Yao Y-G*. 2017. Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)? Zoological Research, 38: 118-126

23.    Li G-D, Bi R, Zhang D-F, Xu M, Luo R, Wang D; Alzheimer's Disease Neuroimaging Initiative (ADNI)., Fang Y, Li T, Zhang C, Yao Y-G*. 2017. Female-specific effect of the BDNF gene on Alzheimer's disease. Neurobiology of Aging, 53: 192.e11 - 192.e19 (doi: 10.1016/j.neurobiolaging.2016.12.023)

24.    Li C-H, Yan L-Z, Ban W-Z, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma Y-H, Nie W-H, Lv L-B, Yao Y-G*, Zhao X-D*, Zheng P*. 2017. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research, 27: 241-252

25.    Wu Y, Yao Y-G*, Luo X-J*. 2017. SZDB: a database for schizophrenia genetic research. Schizophrenia Bulletin, 43: 459-471

26.    Xiang Q, Bi R*, Xu M, Zhang D-F, Tan L, Zhang C, Fang Y, Yao Y-G*. 2017. Rare genetic variants of the Transthyretin gene are associated with Alzheimer's disease in Han Chinese. Molecular Neurobiology, 54: 5192-5200

27.    Li H, Bi R, Fan Y, Wu Y, Tang Y, Li Z, He Y, Zhou J, Tang J*, Chen X*, Yao Y-G*. 2017. mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia. Molecular Neurobiology, 54: 4343-4352

28.    Zhang A-M, Bi R, Hu Q-X, Fan Y, Zhang Q, Yao Y-G*. 2017. The OPA1 gene mutations are frequent in Han Chinese patients with suspected optic neuropathy. Molecular Neurobiology, 54: 1622-1630

29.    Wang D, Zhang D-F, Feng J-Q, Li G-D, Li X-A, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2016. Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China. Scientific Reports, 6: 37086 (doi: 10.1038/srep37086)

30.    Shen Q-K, Sulaiman X, Yao Y-G, Peng M-S, Zhang Y-P. 2016. Was ADH1B under selection in European populations? American Journal of Human Genetics, 99: 1217-1219

31.    Rakha A, Peng M-S, Bi R, Song J-J, Salahudin Z, Adan A, Israr M, Yao Y-G. 2016. EMPOP-quality mtDNA control region sequences from Kashmiri of Azad Jammu & Kashmir, Pakistan. Forensic Science International: Genetics, 25: 125-131

32.    Wang D, Li G-D, Zhang D-F, Xu L, Li X-A, Yu X-F, Long H, Li Y-Y, Yao Y-G*. 2016. Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China. Infection, Genetics and Evolution, 45: 105-110

33.    Wang M-S, Huo Y-X, Li Y, Otecko NO, Su L-Y, Xu H-B, Wu S-F, Peng M-S, Liu H-Q, Zeng L, Irwin DM, Yao Y-G, Wu D-D, Zhang Y-P. 2016. Comparative population genomics reveals genetic basis underlying body size of domestic chickens. Journal of Molecular Cell Biology, 8: 542-552

34.    Li G-D, Wang D, Zhang D-F, Xiang Q, Feng J-Q, Li X-A, Li Y-Y, Yao Y-G*. 2016. Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy. Journal of Dermatological Science, 84: 322-329 (doi: 10.1016/j.jdermsci.2016.09.018)

35.    Huo Y-X, Huang L, Zhang D-F, Yao Y-G, Fang Y-R, Zhang C, Luo X-J. 2016. Identification of SLC25A37 as a major depressive disorder risk gene. Journal of Psychiatric Research, 83: 168-175

36.    Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y-G*. 2016. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proceedings of the National Academy of Sciences of the United States of America, 113: 10950-10955

37.    Wei J-K, Wang W-C, Zhai R-W, Zhang Y-H, Yang S-C, Rizak J, Li L, Xu L-Q, Liu L, Pan M-K, Hu YZ, Ghanemi A, Wu J, Yang L-C, Li H, Lv L-B, Li J-L, Yao Y-G, Xu L, Feng X-L, Yin Y, Qin D-D, Hu X-T, Wang Z-B. 2016. Neurons differentiated from transplanted stem cells respond functionally to acoustic stimuli in the awake monkey brain. Cell Reports, 16: 1016-1025

38.    Wang M-S, Zhang R-W, Su L-Y, Li Y, Peng M-S, Liu H-Q, Zeng L, Irwin DM, Du J-L, Yao Y-G, Wu D-D, Zhang Y-P. 2016. Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication. Cell Research, 26: 556-573

39.    Zhang C, Zhang D-F, Wu Z-G, Peng D-H, Chen J, Ni J, Tang W, Xu L, Yao Y-G*, Fang Y-R*. 2016. Complement factor H and susceptibility to major depressive disorder in Han Chinese. British Journal of Psychiatry, 208: 446-452

40.    Yu D, Wu Y, Xu L, Fan Y, Peng L, Xu M, Yao Y-G*. 2016. Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis). Developmental and Comparative Immunology, 60: 127-138

41.    Li M, Huang L, Li K, Huo Y, Chen C, Wang J, Liu J, Luo Z, Chen C, Dong Q, Yao Y-G, Su B, Luo X-J. 2016. Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations. Human Genetics, 135: 377-392

42.    Bi R, Tang J, Zhang W, Li X, Chen S-Y, Yu D, Chen X, Yao Y-G*. 2016. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Schizophrenia Research, 171: 200-206

43.    Zhang D-F*, Wang D, Li Y-Y, Yao Y-G*. 2016. Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile. Journal of Dermatological Science, 82: 18-27 (doi: 10.1016/j.jdermsci.2016.01.001)

44.    Liu C, Saffen D, Schulze TG, Burmeister M, Sham PC, Yao Y-G, Kuo PH, Chen C, An Y, Dai J, Yue W, Li MX, Xue H, Su B, Chen L, Shi Y, Qiao M, Liu T, Xia K, Chan RC. 2016. Psychiatric genetics in China: achievements and challenges. Molecular Psychiatry, 21: 4-9 (doi: 10.1038/mp.2015.95)

45.    Wang H-Z, Bi R, Zhang D-F, Li G-D, Ma X-H, Fang Y, Li T, Zhang C, Yao Y-G*. 2016. Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese. Molecular Neurobiology, 53: 4883-4892

46.    Li M, Luo XJ, Landén M, Bergen SE, Hultman CM, Li X, Zhang W, Yao Y-G, Zhang C, Liu J, Mattheisen M, Cichon S, Mühleisen TW, Degenhardt FA, N?then MM, Schulze TG, Grigoroiu-Serbanescu M, Li H, Fuller CK, Chen C, Dong Q, Chen C, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Preisig M, Kutalik Z, Castelao E, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG; MooDS Consortium; Swedish Bipolar Study Group, Rietschel M, Liu C, Kleinman JE, Hyde TM, Weinberger DR, Su B. 2015. Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance. British Journal of Psychiatry, 208: 128-137

47.    Zhang D-F, Li J, Wu H, Cui Y, Bi R, Zhou H-J, Wang H-Z, Zhang C, Wang D; Alzheimer's Disease Neuroimaging Initiative (ADNI), Kong Q-P, Li T, Fang Y, Jiang T*, Yao Y-G*. 2016. CFH variants affect structural and functional brain changes and genetic risk of Alzheimer's disease. Neuropsychopharmacology, 41: 1034-1045

48.    Li M, Wu D-D, Yao Y-G, Huo Y-X, Liu JW, Su B, Chasman DI, Chu A-Y, Huang T, Qi L, Zheng Y; CHARGE Nutrition Working Group; DietGen Consortium, Luo X-J. 2016. Recent positive selection drives the expansion of a schizophrenia risk nonsynonymous variant at SLC39A8 in Europeans. Schizophrenia Bulletin, 42: 178-190

49.    Wang H-Z, Bi R, Hu Q-X, Xiang Q, Zhang C, Zhang D-F, Zhang W, Ma X, Guo W, Deng W, Zhao L, Ni P, Li M, Fang Y, Li T, Yao Y-G*. 2016. Validating GWAS-identified risk loci for Alzheimer's disease in Han Chinese populations. Molecular Neurobiology, 53: 379-390

50.    Zhang D-F, Fan Y, Wang D, Bi R, Zhang C, Fang Y, Yao Y-G*. 2016. PLD3 in Alzheimer's disease: a modest effect as revealed by updated association and expression analyses. Molecular Neurobiology, 53: 4034-4045

51.    Zhang A-M, Hu Q-X, Liu F-L, Bi R, Yang B-Q, Zhang W, Guo H, Logan I, Zheng Y-T*, Yao Y-G*. 2016. Mitochondrial DNA haplogroup A decreases the risk of drug addiction but conversely increases the risk of HIV-1 infection in Chinese addicts. Molecular Neurobiology, 53: 3873-3881

52.    Xiang Y-L, Zhang D-F, Wang D, Li Y-Y*, Yao Y-G*. 2015. Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China. Journal of Dermatological Science, 80: 133-141 (doi: 10.1016/j.jdermsci.2015.09.001)

53.    Su L-Y, Li H, Lv L, Feng Y-M, Li G-D, Luo R, Zhou H-J, Lei X-G, Ma L, Li J-L, Xu L, Hu X-T*, Yao Y-G*. 2015. Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation. Autophagy, 11: 1745-1759

54.    Yao Y-G*, Chen YB, Liang B. 2015. The 3rd symposium on animal models of primates - the application of non-human primates to basic research and translational medicine. Journal of Genetics and Genomics, 42: 339-341

55.    Hu Q-X, Fan Y, Xu L, Pang W, Wang S, Zheng Y-T, Lv LB, Yao Y-G*. 2015. Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina. Gene, 571: 279-285 (doi: 10.1016/j.gene.2015.06.085)

56.    Yao Y-G*, Kajigaya S, Young NS. 2015. Mitochondrial DNA mutations in single human blood cells. Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, 779: 68-77

57.    Li X, Zhang W, Tang J, Tan L, Luo X-J, Chen X*, Yao Y-G*. 2015. Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations? Scientific Reports, 5: 11076 (doi: 10.1038/srep11076)

58.    Xu L, Yu D, Peng L, Fan Y, Chen J, Zheng Y-T, Wang C, Yao Y-G*. 2015. Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis). Developmental and Comparative Immunology, 52: 58-68 (doi: 10.1016/j.dci.2015.04.014)

59.    Li X, Zhang W, Lencz T, Darvasi A, Alkelai A, Lerer B, Jiang HY, Zhang D-F, Yu L, Xu X-F, Li M*, Yao Y-G*. 2015. Common variants of IRF3 conferring risk of schizophrenia. Journal of Psychiatry Research, 64: 67-73

60.    Zhang C-C, Ren H-Y, Li M-L, Wang Q, Deng W, Guo WJ, Lei W, Xiang B, Zhao L-S, Ma X-H, Yao Y-G, Li T. 2015. Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese. Neuroscience Bulletin, 31: 368-370

61.    Luo X-j, Huang L, van den Oord EJ, Aberg KA, Gan L, Zhao Z, Yao Y-G. 2015. Common variants in the MKL1 gene confer risk of schizophrenia. Schizophrenia Bulletin, 41: 715-727 (doi:10.1093/schbul/sbu156)

62.    Peng M-S, Shi N-N, Yao Y-G, Zhang Y-P. 2015. Caveats about interpretation of ancient chicken mtDNAs from northern China. Proceedings of the National Academy of Sciences of the United States of America, 112: E1970- E1971

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68.    Wang D, Xu L, Lv L, Su L-Y, Zhang D-F, Bi R, Yu D, Zhang W, Fan Y, Li X-A, Li Y-Y, Yao Y-G*. 2015. Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China. Genes and Immunity, 16: 112-119

69.    Li X, Zhang W, Zhang C, Yi Z, Zhang D-F, Gong w, Tang J, Wang D, Lu W, Chen X, Fang Y, Yao Y-G*. 2015. Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese. Molecular Genetics and Genomics, 290: 585-592 (doi: 10.1007/s00438-014-0942-1)

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75.    Bi R, Zhao L, Zhang C, Lu W, Feng J-Q, Wang Y, Ni J, Zhang J, Li G-D, Hu Q-X, Wang D, Yao Y-G*, Li T*. 2014. No association of the LRRK2 genetic variants with Alzheimer’s disease in Han Chinese. Neurobiology of Aging, 35: 444.e5-9 (doi: 10.1016/j.neurobiolaging.2013.08.013)

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77.    Zhang W, Tang J, Zhang A-M, Peng M-S, Xie H-B, Tan L, Xu L, Zhang Y-P, Chen X*, Yao Y-G*. 2014. A matrilineal genetic legacy from the last glacial maximum confers susceptibility to schizophrenia in Han Chinese. Journal of Genetics and Genomics, 41: 397-407 (http://dx.doi.org/10.1016/j.jgg.2014.05.004)

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79.    Li W-L*, Xiao M-S, Zhang D-F, Yu D, Yang R-X, Li X-Y, Yao Y-G*. 2014. Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer. Gene, 546: 263-270

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81.    Shao X-L, He S-Y, Zhuang X-Y, Fan Y, Li Y-H, Yao Y-G. 2014. mRNA expression and DNA methylation in three key genes involved in caste differentiation in female honeybees (Apis mellifera). Zoological Research, 35: 92-98

82.    Li X, Zhang W*, Zhang C, Gong W, Tang J, Yi Z, Wang D, Lu W, Fang Y, Chen X, Yao Y-G*. 2014. No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese. Neuroscience Letters, 566: 210-215 (doi: 10.1016/j.neulet.2014.03.006)

83.    Yu D, Xu L, Peng L, Chen S-Y, Liu Y-P, Yao Y-G*. 2014. Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens. Gene, 545: 226-232

84.    Fan Y, Yu D, Yao Y-G*. 2014. The positively selected genes of the locomotion system in Chinese tree shrew (Tupaia belangeri chinensis). Zoological Research, 35: 240-248

85.    Sun J, Zhang S, He D-Q, Chen S-Y, Duan Z-Y, Yao Y-G, Liu Y-P. 2014. Matrilineal genetic structure of domestic geese. The Journal of Poultry Science, 51: 130-137 (doi: 10.2141/jpsa.0120152)

86.    Huang J, Zhou B, He D-Q, Chen S-Y, Zhu Q, Yao Y-G, Liu Y-P. 2014. Sequence variation of melanocortin 1receptor (MC1R) gene and association with plumage color in domestic geese. The Journal of Poultry Science, 51: 270-274 (doi: 10.2141/jpsa.0130066)

87.    Peng M-S, He J-D, Fan L, Liu J, Adeola AC, Wu SF, Murphy RW, Yao Y-G, Zhang Y-P. 2014. Retrieving Y chromosomal haplogroup trees using GWAS data. European Journal of Human Genetics, 22: 1046-1050 (doi: 10.1038/ejhg.2013.272).

88.    Bandelt HJ, Kloss-Brandst?tter A, Richards MB, Yao YG, Logan I. 2014. The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies. Journal of Human Genetics, 59: 66-77

89.    Hu SP, Du JP, Li DR, Yao YG. 2014. Mitochondrial DNA haplogroup confers genetic susceptibility to nasopharyngeal carcinoma in Chaoshanese from Guangdong, China. PLoS One, 9: e87795 (doi: 10.1371/journal.pone.0087795)

90.    Lu J, Xu L, Zou Y, Yang RX, Fan Y, Zhang W, Yu D, Yao YG. 2014. IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma. Medical Science Monitor, 20: 247-254

91.    Zheng M, Bi R, Li W, Landeck L, Chen JQ, Lao LM, Cai SQ, Yao YG, Man XY. 2013. eneralized pure cutaneous Rosai-Dorfman disease: a link between inflammation and cancer not associated with mitochondrial DNA and SLC29A3 gene mutation? Discovery Medicine, 16: 193-200

92.    Yao Y-G*, Kajigaya S, Samsel L, McCoy JP Jr, Torelli G, Young NS. 2013. Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport. Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, 751-752: 36-41 (doi:10.1016/j.mrfmmm.2013.09.001)

93.    Liu YP, Lai R, Yao YG, Zhang ZK, Pu ET, Cai XH, Luo XD. 2013. Induced furoeudesmanes: a defense mechanism against stress in Laggera pterodonta, a Chinese herbal plant. Organic Letters, 15: 4940-4943

94.    Sun J, Zhong H, Chen SY, Yao YG, Liu YP. 2013. Association between MT-CO3 haplotypes and high-altitude adaptation in Tibetan chicken. Gene, 529:131-137

95.    Feng Y-M, Jia Y-F, Su L-Y, Wang D, Lv L, Xu L*, Yao Y-G*. 2013. Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. Autophagy, 9: 1395-1406

96.    Zhang A-M, Wang H, Sun P, Hu Q-X, He Y-Q, Yao Y-G*. 2013. Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families. Molecular Vision, 19: 1631-1638

97.    Ma L, Tang J, Wang D, Zhang W, Liu W, Wang D, Liu X-H, Gong W, Yao Y-G*, Chen X*. 2013. Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China. Molecular Psychiatry, 18: 638-639

98.    Xiao M-S, Chang L, Li W-L, Du Y-S, Pan Y, Zhang D-F, Wen Y, Luo J, Li X-Y*, Yao Y-G*. 2013. Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from Southwest China. PLoS ONE, 8: e67577

99.    Fan L, Yao Y-G*. 2013. An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination. Mitochondrion, 13: 360-363

100. Zhang D-F, Huang X-Q, Wang D, Li Y-Y, Yao Y-G*. 2013. Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China. Human Genetics, 132: 629-640

101. Zhuang XY, Yao YG*. 2013. Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands. FEBS Letters, 587: 1656-1662

102. Tu Z, Zhuang X, Yao Y-G, Zhang R. 2013. BRG1 is required for formation of senescence-associated heterochromatin foci (SAHF) induced by oncogenic RAS or BRCA1 loss. Molecular and Cellular Biology, 33:1819-1829 (doi:10.1128/MCB.01744-12).

103. Fan Y, Huang Z-Y, Cao C-C, Chen C-S, Chen Y-X, Fan D-D, He J, Hou H-L, Hu L, Hu X-T, Jiang X-T, Lai R, Lang Y-S, Liang B, Liao S-G, Mu D, Ma Y-Y, Niu Y-Y, Sun X-Q, Xia J-Q, Xiao J, Xiong Z-Q, Xu L, Yang L, Zhang Y, Zhao W, Zhao X-D, Zheng Y-T, Zhou J-M, Zhu Y-B, Zhang G-J*, Wang J*, Yao Y-G*. 2013. Genome of the Chinese tree shrew. Nature Communications, 4:1426 (doi: 10.1038/ncomms2416)

104. Yao Y-G*, Kajigaya S, Feng X, Samsel L, McCoy JP, Jr, Torelli G, Young NS. 2013. Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background. Stem Cell Research, 10:361-370 (http://dx.doi.org/10.1016/j.scr.2013.01.006)

105. Li Y-Y, Chen W-Y, Li X, Li H-B, Li H-Q, Wang L, He L, Yang X-P, Wang X-C, Huang Y-L, Yao Y-G. 2013. Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan province of China. BMC Infectious Diseases, 13(1):46 (doi:10.1186/1471-2334-13-46).

106. Li D-X, Zhuang X-Y, Zhang Y-P, Guo H, Wang Z, Zhang Q, Feng Y-M, Yao Y-G*. 2013. Effects of tai chi on the protracted abstinence syndrome: a time trial analysis. The American Journal of Chinese Medicine, 41:43-57 (doi: 10.1142/S0192415X13500043)

107. Ma L, Zhang W, Tang J, Tan L, Yao Y-G*, Chen X. 2013. No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese. Psychiatric Genetics, 23:29-32 (doi: 10.1097/YPG.0b013e32835862c5)

108. Miao Y-W, Peng M-S, Wu G-S, Ouyang Y-N, Yang Z-Y, Yu N, Liang J-P, Pianchou G, Beja-Pereira A, Mitra B, Palanichamy M-G, Baig M, Chaudhuri TK, Shen Y-Y, Kong Q-P, Murphy RW, Yao Y-G, Zhang Y-P. 2013. Chicken domestication: an updated perspective based on mitochondrial genomes. Heredity, 110: 277-282 (doi: 10.1038/hdy.2012.83).

109. Xu L, Fan Y, Jiang X-L, Yao Y-G*. 2013. Molecular evidence on the phylogenetic position of tree shrews. Zoological Research, 34: 70-76 (in Chinese)

110. Xu L, Zhang Y, Liang B, Lü L-B, Chen C-S, Chen Y-B, Zhou J-M, Yao Y-G*. 2013. Tree shrews under the spot light: emerging model of human diseases. Zoological Research, 34: 59-69  (in Chinese)

111. Liu X, Yao Y-G*. 2013. Characterization of 12 polymorphic microsatellite markers in the Chinese tree shrew (Tupaia belangeri chinensis). Zoological Research, 34 (E2): E62-E68

112. Zhang A-M, Yao Y-G*. 2013. Research progress of Leber hereditary optic neuropathy. Hereditas (Beijing), 35: 123-135 (in Chinese)

113. Chen S-Y, Yao Y-G, Liu Y-P. 2012. Species identification of ten common farm animals based on mitochondrial 12S rRNA gene polymorphisms. Animal Biotechnology, 23:213-220 (doi: 10.1080/10495398.2012.696568)

114. Bi R, Zhang A-M, Jia X, Zhang Q, Yao Y-G*. 2012. Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G>A and Leber hereditary optic neuropathy. Molecular Vision, 18:3087-3094

115. Guo H, Zhuang X-Y, Zhang A-M, Zhang W, Yuan Y, Guo L, Yu D-D, Liu J, Yang D-K, Yao Y-G*. 2012. Presence of mutation m.14484T>C in a Chinese family with maternally inherited essential hypertension but no expression of LHON. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1822:1535-1543 (doi: 10.1016/j.bbadis.2012.06.010)

116. Li Y, Zhang D-F, Zhang S-W, Zeng Y*, Yao Y-G*. 2012. Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease. International Journal of Hematology, 96:229-233 (doi: 10.1007/s12185-012-1104-z)

117. Zhang A-M, Jia X, Guo X, Zhang Q*, Yao Y-G*. 2012. Mitochondrial DNA mutation m.10680G>A is associated with Leber hereditary optic neuropathy in Chinese patients. Journal of Translational Medicine, 10(1):43 (doi:10.1186/1479-5876-10-43)

118. Wang D, Feng JQ, Li Y-Y, Zhang D-F, Li X-A, Li Q-W, Yao Y-G*. 2012. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China. Human Genetics, 131:1251-1260 (doi: 10.1007/s00439-012-1153-7)

119. He J-D, Peng M-S, Quang H-H, Dang K-P, Trieu AV, Wu S-F, Jin J-Q, Murphy RW, Yao Y-G, Zhang Y-P. 2012. Patrilineal perspective on the Austronesian diffusion in Mainland Southeast Asia. PLoS ONE, 7(5): e36437

120. Wang D, Su L-Y, Zhang A-M, Li Y-Y, Li X-A, Chen L-L, Long H, Yao Y-G*. 2012. Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from southwest China. PLoS ONE, 7(6): e38848

121. Liu J, Wang L-D, Sun Y-B, Li E-M, Xu L-Y, Zhang Y-P, Yao Y-G, Kong Q-P. 2012. Deciphering the signature of selective constraints on cancerous mitochondrial genome. Molecular Biology and Evolution, 29: 1255-1261

122. Xu L, Chen S-Y, Nie W-H, Jiang X-L, Yao Y-G*. 2012. Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: implication for using tree shrew as an alternative experimental animal to primates in biomedical research. Journal of Genetics and Genomics, 39: 131-137

123. Zhang Z-R, Zhu Q, Yao Y-G, Jiang X-S, Du R-H, Liu Y-P. 2012. Characterization of the expression profile of calpain-3 (CAPN3) gene in chicken. Molecular Biology Reports, 39: 3517-3521

124. Zhang A-M, Jia X, Bi R, Salas A, Li S, Xiao X, Wang P, Guo X, Kong Q-P, Zhang Q*, Yao Y-G*. 2011. Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients. PLoS ONE, 6(11): e27750 (doi:10.1371/journal.pone.0027750)

125. Lu F-Y, Xu L, Yin X-G, Wan P, Zhang X-D, Chen W-W, Ding S-P, Yao Y-G*. 2011. Identification of mutation c.632G>A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier’s disease. International Journal of Dermatology, 50: 1366-1370 (doi: 10.1111/j.1365-4632.2011.05129.x)

126. Zhang A-M, Bandelt H-J, Jia X, Zhang W, Li S, Yu D, Wang D, Zhuang X-Y, Zhang Q*, Yao Y-G*. 2011. Is mitochondrial tRNAphe variant m.593T>C a synergistically pathogenic mutation in Chinese LHON families with m.11778G>A? PLoS ONE, 6(10): e26511 (doi: 10.1371/journal.pone.0026511)

127. Kong Q-P, Sun C, Wang H-W, Zhao M, Wang W-Z, Zhong L, Hao X-D, Pan H, Wang S-Y, Cheng Y-T, Zhu C-L, Wu S-F, Liu L-N, Jin J-Q, Yao Y-G, Zhang Y-P. 2011. Large-scale mtDNA screening reveals a surprising matrilineal complexity in East Asia and its implications to the peopling of the region. Molecular Biology and Evolution, 28: 513-522

128. Xiao M-S, Zhang D-F, Zeng Y, Cheng Y-F, Yao Y-G*. 2011. Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients. Annals of Hematology, 90: 1137-1144

129. Bi R, Zhang A-M, Yao Y-G. 2011. Leber's Hereditary Optic Neuropathy. Ophthalmology, 118:1489-1489.e1 (doi:10.1016/j.ophtha.2011.04.007; comments)

130. Liu F-L, Yao Y-G, Li H, Zheng Y-T. 2011. Human rights, ethics, and the protection of intravenous drug users are much improved in China. JAIDS Journal of Acquired Immune Deficiency Syndromes, 57:e31-e32

131. Chen S-Y, Xu L, Lü L-B, Yao Y-G*. 2011. Genetic diversity and matrilineal structure in Chinese tree shrews inhabiting Kunming, China. Zoological Research 32:17-23

132. Bi R, Li W-L, Chen M-Q, Zhu Z, Yao Y-G*. 2011. Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 709-710:15-20

133. Fan L, Yao Y-G*. 2011. MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations. Mitochondrion, 11: 351-356

134. Peng M-S, Palanichamy MG, Yao Y-G, Mitra B, Cheng YT, Zhao M, Liu J, Wang H-W, Pan H, Wang W-Z, Zhang A-M, Zhang W, Wang D, Zou Y, Yang Y, Chaudhuri TK, Kong Q-P, Zhang Y-P. 2011. Inland post-glacial dispersal in East Asia revealed by mitochondrial haplogroup M9a'b. BMC Biology 9: 2 (doi: 10.1186/1741-7007-9-2.)

135. Wang Y, Zhu Q, Zhao XL, Yao Y-G, Liu Y-P. 2011. Age-related expression profile of the SLC27A1 gene in chicken tissues. Molecular Biology Reports, 38: 5139-5145

136. Li Y-Y, Li X-A, He L, Qang D, Chen W-Y, Chen L, Lu J-B, Yao Y-G. 2011. Trends in new leprosy case detection over 57 years (1952-2008) in Yuxi, Yunnan Province of Southwest China. Leprosy Review, 82:6-16

137. Zhang W, Chen X*, Gong W, Tang J, Tan L, Guo H, Yao Y-G*. 2010. Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese. Behavioral and Brain Functions 6: 75 (doi:10.1186/1744-9081-6-75)

138. Yu D, Jia X, Zhang A-M, Li S, Zou Y, Zhang Q*, Yao Y-G*. 2010. Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C. PLoS ONE,  5(10): e13426

139. Chen S-Y, Liu Y-P, Yao Y-G*. 2010. Species authentication of commercial beef jerky based on PCR-RFLP analysis of the mitochondrial 12S rRNA gene. Journal of Genetics and Genomics 37: 763-769

140. Zou Y, Zeng Y, Zhang D-F, Zou S-H, Cheng Y-F*, Yao Y-G*. 2010. IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders. Biochemical and Biophysical Research Communications, 402: 378-383

141. Bi R, Zhang A-M, Zhang W, Kong Q-P, Wu B-L, Yang X-H, Wang D, Zou Y, Zhang Y-P, Yao Y-G*. 2010. The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells. Human Mutation, 31: 538-543

142. Zou Y, Jia X, Zhang A-M, Wang W-Z, Li S, Guo X, Kong Q-P, Zhang Q*, Yao Y-G*. 2010. The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations. Biochemical and Biophysical Research Communications, 399: 179-185

143. Zhang A-M, Jia X, Zhang Q*, Yao Y-G*. 2010. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A. Human Genetics, 128: 465-468

144. Bi R, Zhang A-M, Yu D, Chen D, Yao Y-G*. 2010. Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR. Clinica Chimica Acta, 411: 1671-1674

145. Peng M-S, Quang H-H, Dang K-P, Trieu A-V, Wang H-W, Yao Y-G, Kong Q-P, Zhang Y-P. 2010. Tracing the Austronesian footprint in mainland Southeast Asia: a perspective from mitochondrial DNA. Molecular Biology and Evolution, 27: 2417-2430

146. Yu D, Jia X, Zhang A-M, Guo X, Zhang Y-P, Zhang Q*, Yao Y-G*. 2010. Molecular characterization of six Chinese families with m.3460G>A and Leber hereditary optic neuropathy. Neurogenetics, 11: 349-356

147. Wang Y, Zhu Q, Zhao XL, Yao Y-G*, Liu Y-P*. 2010. Association of FATP1 gene polymorphisms with chicken carcass traits in Chinese meat-type quality chicken populations. Molecular Biology Reports, 37: 3683-3690

148. Kong Q-P, Bandelt H-J, Zhao M, Zhang Y-P, Yao Y-G. 2010. Reply to van Oven: Suggestions and caveats for naming mtDNA haplogroup. Proceedings of the National Academy of Sciences of the United States of America, 107: E40-E41 (doi:10.1073/pnas.1000977107; comment)

149. Wang Q, Wang P, Li S, Xiao X, Jia X, Guo X, Kong Q-P, Yao Y-G, Zhang Q. 2010. Mitochondrial DNA haplogroup distribution in Chaoshanese with and without myopia. Molecular Vision, 16: 303-309

150. Zhou B, Chen S-Y, Zhu Q, Yao Y-G, Liu Y-P. 2010. Matrilineal components and genetic relationship of Silkies from China and Japan. Journal of Poultry Science, 47: 22-27

151. Yao Y-G, Salas A, Logan I, Bandelt H-J. 2009. mtDNA data-mining in GenBank needs surveying. American Journal of Human Genetics, 85: 929-933

152. Zhao M, Kong Q-P, Wang H-W, Peng M-S, Xie X-D, Wang W-Z, Jiayang, Duan J-G, Cai M-C, Zhao S-N, Cidanpingcuo, Tu Y-Q, Wu SF, Yao Y-G, Bandelt H-J, Zhang Y-P. 2009. Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau. Proceedings of the National Academy of Sciences of the United States of America, 106: 21230-21235

153. Bandelt H-J, Salas A, Taylor RW, Yao Y-G*. 2009. The exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searches. Human Mutation, 30: 191-196

154. Zhang A-M, Zou Y, Guo X, Jia X, Zhang Q*, Yao Y-G*. 2009 Mitochondrial DNA mutation m.3635G>A may be associated with Leber hereditary optic neuropathy in Chinese. Biochemical and Biophysical Research Communications, 386: 392-395

155. Chen S-Y, Huang Y, Zhu Q, Fontanesi L, Yao Y-G*, Liu Y-P*. 2009. Sequence characterization of the MC1R gene in yak (Poephagus grunniens) breeds with different coat colours. Journal of Biomedicine and Biotechnology, Volume 2009, Article ID 861046; doi:10.1155/2009/861046

156. Zhang Z-R, Liu Y-P, Yao Y-G, Jiang X, Du H, Zhu Q. 2009. Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens. BMC Genetics, 10: 10; doi:10.1186/1471-2156-10-10

157. Bandelt H-J, Yao Y-G, Bravi CM, Salas A, Kivisild T. 2009. Median network analysis of defectively sequenced entire mitochondrial genomes from early and contemporary disease studies. Journal of Human Genetics, 54: 174-181

158. Liu Y-P, Cao S-X, Chen S-Y, Yao Y-G, Liu T-Z. 2009. Genetic diversity of Chinese domestic goat based on the mitochondrial DNA sequence variation. Journal of Animal Breeding and Genetics, 126: 80-89

159. Ji Y, Zhang A-M, Jia X, Zhang Y-P, Xiao X, Li S, Guo X, Bandelt H-J, Zhang Q, Yao Y-G*. 2008. Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber Hereditary Optic Neuropathy in Chinese families with the m.11778G→A mutation. American Journal of Human Genetics, 83: 760-768

160. Yao Y-G*, Kong Q-P, Salas A, Bandelt H-J. 2008. Pseudo-mitochondrial genome haunts disease studies. Journal of Medical Genetics, 45: 769-772

161. He D-Q, Zhu Q, Chen S-Y, Wang H-Y, Liu Y-P*, Yao Y-G*. 2008. A homogenous nature of Chinese native duck matrilineal pool. BMC Evolutionary Biology, 8: 298; doi:10.1186/1471-2148-8-298

162. Bandelt H-J, Yao Y-G, Richards M, Salas A. 2008. The brave new era of human genetic testing. BioEssays, 30: 1246-1251

163. Kong Q-P, Salas A, Sun C, Fuku N, Tanaka M, Zhong L, Wang C-Y, Yao Y-G, Bandelt H-J. 2008. Distilling artificial recombinants from large sets of complete mtDNA genomes. PLoS ONE, 3:e3016; doi:10.1371/journal.pone.0003016

164. Zhang A-M, Jia X, Yao Y-G*, Zhang Q*. 2008. Co-occurrence of A1555G and G11778A in a Chinese family with high penetrance of Leber's hereditary optic neuropathy. Biochemical and Biophysical Research Communications, 376: 221-224

165. Wang H-W, Jia X, Ji Y, Kong Q-P, Zhang Q*, Yao Y-G*, Zhang Y-P. 2008. Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is independent of mtDNA haplogroup background and secondary mutation G13708A. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 643: 48-53

166. Bandelt H-J, Yao Y-G, Salas A. 2008. The search of 'novel' mtDNA mutations in hypertrophic cardiomyopathy: MITOMAPping as a risk factor. International Journal of Cardiology, 126: 439-442

167. Chen S-Y, Liu Y-P, Wang W, Gao C-Z, Yao Y-G, Lai S-J. 2008. Dissecting the matrilineal components of Tongjiang cattle from southwest China. Biochemical Genetics, 46: 206-215

168. Ji Y, Jia X, Zhang Q, Yao Y-G. 2007. mtDNA haplogroup distribution in Chinese patients with Leber’s hereditary optic neuropathy and G11778A mutation. Biochemical and Biophysical Research Communications, 364: 238-242

169. Wu G-S, Yao Y-G, Qu K-X, Ding Z-L, Li H, Palanichamy Mg, Duan Z-Y, Li N, Chen Y-S, Zhang Y-P. 2007. Population phylogenomic analysis of mitochondrial DNA in wild boars and domestic pigs revealed multiple domestication events in East Asia. Genome Biology, 8:R245;  doi:10.1186/gb-2007-8-11-r245

170. Yao Y-G*, Childs RW, Kajigaya S, McCoy JP, Jr, Young NS. 2007. Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation. Stem Cells, 25:2670-2676

171. Yao Y-G*, Bandelt H-J, Young NS. 2007. External contamination in single cell mtDNA analysis. PLoS ONE, 2: e681; doi:10.1371/journal.pone.0000681

172. Wang C-Y, Wang H-W, Yao Y-G, Kong Q-P, Zhang Y-P. 2007. Somatic mutations of mitochondrial genome in early stage breast cancer. International Journal of Cancer, 121: 1253-1256

173. Bandelt H-J, Olivieri A, Bravi C, Yao Y-G, Torroni A, Salas A. 2007. ‘Distorted’ mitochondrial DNA sequences in schizophrenic patients. European Journal of Human Genetics, 15: 400-402

174. Yao Y-G*, Ogasawara Y, Kajigaya S, Molldrem JJ, Falc?o RP, Pint?o M-C, McCoy JC, Jr, Rizzatti EG, Young NS*. 2007. Mitochondrial DNA sequence variation in single cells from leukemia patients. Blood, 109: 756-762

175. Yao Y-G*, Ellison FM, McCoy JP, Jr, Chen J, Young NS. 2007. Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background. Human Molecular Genetics, 16: 286-294

176. Lai S-J, Chen S-Y, Liu Y-P, Yao Y-G. 2007. Mitochondrial DNA sequence diversity and origin of Chinese domestic yak. Animal Genetics, 38: 77-80

177. Bandelt H-J, Yao Y-G, Salas A, Kivisild T, Bravi CM. 2007. High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patients. Biochemical and Biophysical Research Communications, 352: 283-291

178. Wang C-Y, Kong Q-P, Yao Y-G*, Zhang Y-P. 2006. MtDNA mutation C1494T, haplogroup A, and hearing loss in Chinese. Biochemical and Biophysical Research Communications, 348: 712-715

179. Man X-Y, Yang X-H, Cai S-Q, Yao Y-G, Zheng M. 2006. Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis. Molecular Medicine, 12: 127-136

180. Yang X-H, Man X-Y, Cai S-Q, Yao Y-G, Bu Z-Y, Zheng M. 2006. Expression of VEGFR-2 on HaCaT cells is regulated by VEGF and plays an active role in mediating VEGF induced effects. Biochemical and Biophysical Research Communications, 349: 31-38

181. Kong Q-P, Bandelt H-J, Sun C, Yao Y-G, Salas A, Achilli A, Wang C-Y, Zhong L, Zhu C-L, Wu S-F, Torroni A, Zhang Y-P. 2006. Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations. Human Molecular Genetics, 15: 2076-2086

182. Yao Y-G*, Salas A, Bravi CM, Bandelt H-J. 2006. A reappraisal of complete mtDNA variation in East Asian families with hearing impairment. Human Genetics, 119: 505-515

183. Salas A, Yao Y-G, Bandelt H-J. 2006. Mitochondria: more than mitochondrial DNA in cancer - author’s reply. PLoS Medicine, 3: e166; doi:10.1371/journal.pmed.0030166 (comment)

184. Sun C, Kong Q-P, Palanichamy MG, Agrawal S, Bandelt H-J, Yao Y-G, Khan F, Zhu C-L, Chaudhuri TK, Zhang Y-P. 2006. The dazzling array of basal branches in the mtDNA macrohaplogroup M from India as inferred from complete genomes. Molecular Biology and Evolution, 23: 683-690

185. Palanichamy MG, Agrawal S, Yao Y-G, Kong Q-P, Sun C, Khan F, Chaudhuri TK, Zhang Y-P. 2006. Comment on ‘‘Reconstructing the origin of Andaman islanders’’. Science, 311: 470; doi: 10.1126/science.1120176 (comment)

186. Liu Y-P, Zhu Q, Yao Y-G*. 2006. Genetic relationship of Chinese and Japanese gamecocks revealed by mtDNA sequence variation. Biochemical Genetics, 44: 19-29

187. Liu Y-P, Wu G-S, Yao Y-G, Miao Y-W, Luikart G, Baig M, Beja-Pereira A, Ding Z-L, Palanichamy MG, Zeng F-T, Qiu X-P, Zhang Y-P. 2006. Multiple maternal origins of chickens: out of the Asian jungles? Molecular Phylogenetics and Evolution, 38: 12-19

188. Lai S-J, Liu Y-P*, Liu Y-X, Li X-W, Yao Y-G*. 2006. Genetic diversity and origin of Chinese cattle revealed by mtDNA D-loop sequence variation. Molecular Phylogenetics and Evolution, 38: 146-154

189. Salas A, Yao Y-G, Macaulay V, Vega A, Carracedo A, Bandelt H-J. 2005. A critical reassessment of the role of mitochondria in tumorigenesis. PLoS Medicine, 2: e296; doi:10.1371/journal.pmed.0020296

190. Bandelt H-J, Achilli A, Kong Q-P, Salas A, Lutz-Bonengel S, Sun C, Zhang Y-P, Torroni A, Yao Y-G. 2005. Low “penetrance” of phylogenetic knowledge in mitochondrial disease studies. Biochemical and Biophysical Research Communications, 333: 122-130

191. Yao Y-G, Yang HS, Cao Z, Danielsson J, Duh EJ. 2005. Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism. FEBS Letters, 579: 1227-1234

192. Bandelt H-J, Yao Y-G, Kivisild T. 2005. Mitochondrial genes and schizophrenia. Schizophrenia Research, 72: 267-269

193. Yao Y-G, Kong Q-P, Wang C-Y, Zhu C-L, Zhang Y-P. 2004. Different matrilineal contributions to genetic structure of ethnic populations in Silk-Road region in China. Molecular Biology and Evolution, 21: 2265-2280

194. Yao Y-G, Duh EJ. 2004. VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis? Biochemical and Biophysical Research Communications, 321: 648-656

195. Yao Y-G, Bravi CM, Bandelt H-J. 2004. A call for mtDNA data quality control in forensic science. Forensic Science International, 141: 1-6

196. Kong Q-P, Yao Y-G, Sun C, Zhu C-L, Zhong L, Wang C-Y, Cai W-W, Xu X-M, Xu A-L, Zhang Y-P. 2004. Phylogeographic analysis of mitochondrial DNA haplogroup F2 in China reveals T12338C in the initiation codon of the ND5 gene not to be pathogenic. Journal of Human Genetics, 49: 414-423

197. Duh EJ, Yao Y-G, Dagli M, Goldberg MF. 2004. Persistence of fetal vasculature in a patient with Knobloch Syndrome: potential role for endostatin in fetal vascular remodeling of the eye. Ophthalmology, 111: 1885-1888

198. Luan Y-X, Yao Y-G, Xie R-D, Yang Y-M, Zhang Y-P, Yin W-Y. 2004. Analysis of 18S rRNA gene of Octostigma sinensis (Projapygoidea: Octostigmatidae) supports the monophyly of Diplura. Pedobiologia, 48: 453-459

199. Yao Y-G*, Macaulay V, Kivisild T, Zhang Y-P, Bandelt H-J. 2003. To trust or not to trust an idiosyncratic mitochondrial data set. American Journal of Human Genetics, 72: 1341-1346

200. Yao Y-G*, Macaulay V, Kivisild T, Zhang Y-P, Bandelt H-J. 2003. Mitochondrial DNA variation in Amerindians - Reply to Silva et al. American Journal of Human Genetics, 72: 1348-1349 (comment)

201. Yao Y-G, Zhang Y-P. 2003. Pitfalls in the analysis of ancient human mtDNA. Chinese Science Bulletin, 48: 826-830

202. Yao Y-G, Kong Q-P, Sun C, Zhang Y-P. 2003. Can the occurrence of rare insertion/deletion polymorphisms in human mtDNA be verified from phylogeny? Chinese Science Bulletin, 48: 663-667

203. Yao Y-G, Kong Q-P, Man X-Y, Bandelt H-J, Zhang Y-P. 2003. Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA. Molecular Biology and Evolution, 20: 214-219

204. Kong Q-P, Yao Y-G, Liu M, Chen C, Zhu C-L, Palanichamy MG, Zhang Y-P. 2003. Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China. Human Genetics, 113: 391-405

205. Kong Q-P, Yao Y-G, Sun C, Bandelt H-J, Zhu C-L, Zhang Y-P. 2003. Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences. American Journal of Human Genetics, 73: 671-676

206. Bandelt H-J, Herrnstadt C, Yao Y-G, Kong Q-P, Kivisild T, Rengo C, Scozzari R, Richards M, Villems R, Macaulay V, Howell N, Torroni A, Zhang Y-P. 2003. Identification of Native American founder mtDNAs through the analysis of complete mtDNA sequences: some caveats. Annals of Human Genetics, 67: 512-524

207. Kong Q-P, Yao Y-G, Huang S-Y, Huang J-F, Zhang Y-P. 2003. Mitochondrial DNA control region and cytochrome b sequence variation in the genus Mystacoleucus Günther (Pisces: Cyprinidae: Barbinae) from China. Biochemical Genetics, 41: 305-313

208. Man X-Y, Luo H-R, Li X-P, Yao Y-G, Mao C-Z, Zhang Y-P. 2003. Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese. Annals of the Rheumatic Diseases, 62: 71-73

209. Yao Y-G, Kong Q-P, Bandelt H-J, Kivisild T, Zhang Y-P. 2002. Phylogeographic differentiation of mitochondrial DNA in Han Chinese. American Journal of Human Genetics, 70: 635-651

210. Yao Y-G, Nie L, Harpending H, Fu Y-X, Yuan Z-G, Zhang Y-P. 2002. Genetic relationship of Chinese ethnic populations revealed by mtDNA sequence diversity. American Journal of Physical Anthropology, 118: 63-76

211. Yao Y-G, Zhang Y-P. 2002. Phylogeographic analysis of mtDNA variation in four ethnic populations from Yunnan Province: new data and a reappraisal. Journal of Human Genetics, 47: 311-318

212. Yao Y-G, Kong Q-P, Zhang Y-P. 2002. Mitochondrial DNA 5178A polymorphism and longevity. Human Genetics, 111: 462-463

213. Luo H-R, Lü X-M, Yao Y-G, Horie N, Takeishi K, Jorde LB, Zhang Y-P. 2002. Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles. Biochemical Genetics, 40: 41-51

214. Zhang Y-W, Fang Y-H, Long H-S, Yao Y-G, Cai Q, Zhang Y-P. 2002. Sequence variation of rbcL gene and evolution of Saccharum and related species. Acta Botanica Yunnanica, 24: 29-36 (In English with Chinese abstract)

215. Yao Y-G, Yuan Z-G, Zhou Z-D, Geng P-L, Li Q-W, Zhang Y-P. 2001. Frequency of the mtDNA 9-bp deletion in Chinese ethnic groups. Progress in Natural Science, 11: 358-364

216. Yang Z-Q, Zuo Y-X, Yao Y-G, Chen X-W, Yang G-C, Zhang Y-P. 2001. Analysis of the 18S rRNA genes of Sarcocystis species suggests that the morphologically similar organism from cattle and water buffalo should be considered the same species. Molecular and Biochemical Parasitology, 115: 283-288

217. Yao Y-G, Kong Q-P, Zhang Y-P. 2001. Methods and thoughts on detecting nucleotide variation in human mitochondrial DNA. Zoological Research, 22: 321-331 (in Chinese)

218. Yuan Z-G, Yao Y-G, Ma Z-X, Pang Q-P, Jie Y-R, Ma J, Zhang Y-P. 2001. Mitochondrial DNA sequence variations of Zhuang ethnic group in Guangxi. Acta Genetica Sinica, 28:95-102 (in Chinese)

219. Yu Y-S, Yao Y-G, Kong Q-P, Rong J-Q, Luo Z-G, Ren G-X, Zhang Y-P. 2001. Mitochondrial DNA sequence variations of Shui ethnic group. Acta Genetica Sinica, 28: 691-698 (in Chinese)

220. Yao Y-G, Watkins WS, Zhang Y-P. 2000. Evolutionary history of the mtDNA 9-bp deletion in Chinese populations and its relevance to the peopling of East and Southeast Asia. Human Genetics, 107: 504-512

221. Yao Y-G, Lü X-M, Luo H-R, Li W-H, Zhang Y-P. 2000. Gene admixture in the silk road of China: evidence from mtDNA and melanocortin 1 receptor polymorphism. Genes & Genetic Systems, 75: 173-178

222. Ding Y-C, Wooding S, Harpending H, Chi H-C, Li H-P, Fu Y-X, Pang J-F, Yao Y-G, Xiang YJG, Moyzis R, Zhang Y-P. 2000. Population structure and history in East Asia. Proceedings of the National Academy of Sciences of the United States of America, 97: 14003-14006

223. Yao Y-G, Zhang Y-P. 2000. Mitochondrial DNA and human evolution. Zoological Research, 21: 392-406 (in Chinese)

224. Zhou J-L, Yao Y-G, Huang M-H, Yang D-T, Lü S-Q, Zhang Y-P. 2000. Phylogenetic relationships among Viperidae, Crotalinae based on mitochondrial 12S rRNA sequence variations. Acta Genetica Sinica, 27: 283-289 (in Chinese)

  研究团队

工作人员

余丹丹 硕士 副研究员,yudandan@mail.kiz.ac.cn

毕 蕊 博士 副研究员,birui@mail.kiz.ac.cn     

许 凌 博士 副研究员,lingxu0502@yahoo.com

张登峰 博士 副研究员,zhangdengfeng@mail.kiz.ac.cn 

苏凌燕 博士 副研究员,sulingyan@mail.kiz.ac.cn

范 宇 博士 助理研究员,fanyu@mail.kiz.ac.cn

杨禄秀 本科 助理实验师,yangluxiu@mail.kiz.ac.cn 

研究生

武勇 罗荣灿 徐敏 古天乐 姚玉林 刘前进 李余 李桂瑜 焦利进 叶茂森  张金燕 阳静

郑全振 苗莹 曾春华 郑晓 李慧龙