| 论文题目: | Pro-inflammatory Microenvironment and Systemic Accumulation of CXCR3+ cell Exacerbate Lung Pathology of Old Rhesus Macaques Infected with SARS-CoV-2 |
| 作者: | Hong-Yi Zheng, Xiao-Yan He, Wei Li, Tian-Zhang Song, Jian-Bao Han, Xiang Yang , Feng-Liang Liu, Rong-Hua Luo, Ren-Rong Tian, Xiao-Li Feng, Yu-Hua Ma, Chao Liu, Ming-Hua Li, Yong-Tang Zheng |
| 联系作者: | zhengyt@mail.kiz.ac.cn |
| 发表年度: | 2021 |
| DOI: | DOI10.1038/s41392-021-00734-w |
| 摘要: | Understanding the pathological features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an animal model is crucial for the treatment of coronavirus disease 2019 (COVID-19). Here, we compared immunopathological changes in young and old rhesus macaques (RMs) before and after SARS-CoV-2 infection at the tissue level. Quantitative analysis of multiplex immunofluorescence staining images of formalin-fixed paraffin-embedded (FFPE) sections showed that SARS-CoV-2 infection specifically induced elevated levels of apoptosis, autophagy, and nuclear factor kappa-B (NF-kappa B) activation of angiotensin-converting enzyme 2 (ACE2)+ cells, and increased interferon alpha (IFN-alpha)- and interleukin 6 (IL-6)-secreting cells and C-X-C motif chemokine receptor 3 (CXCR3)+ cells in lung tissue of old RMs. This pathological pattern, which may be related to the age-related pro-inflammatory microenvironment in both lungs and spleens, was significantly correlated with the systemic accumulation of CXCR3+ cells in lungs, spleens, and peripheral blood. Furthermore, the ratio of CXCR3+ to T-box protein expression in T cell (T-bet)+ (CXCR3+/T-bet+ ratio) in CD8+ cells may be used as a predictor of severe COVID-19. These findings uncovered the impact of aging on the immunopathology of early SARS-CoV-2 infection and demonstrated the potential application of CXCR3+ cells in predicting severe COVID-19 |
| 刊物名称: | Signal Transduction and Targeted Therapy |
| 论文出处: | https://www.nature.com/articles/s41392-021-00734-w |
| 影响因子: | 18.187(2020年) |
