|论文题目:||Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability|
|作者:||Tang, XP ; Fang, MQ ; Cheng, RM ; Zhang, ZY ; Wang, YM ; Shen, CB ; Han, YJ ; Lu, QM ; Du, YR ; Liu, YY ; Sun, ZH ; Zhu, LP ; Mwangi, J ; Xue, M ; Long, CB ; Lai, R|
Rationale: Epidemiological studies have identified an associate between iron deficiency (ID) and the use of oral contraceptives (CC) and ischemic stroke (IS). To date, however, the underlying mechanism remains poorly understood. Both ID and CC have been demonstrated to upregulate the level and iron-binding ability of Tf (transferrin), with our recent study showing that this upregulation can induce hypercoagulability by potentiating FXIIa/thrombin and blocking antithrombin-coagulation proteases interactions.