| 论文题目: | A Neural Circuit for Comorbid Depressive Symptoms in Chronic Pain |
| 作者: | Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, Mao Y, Wang L, Xie W, Zhong H, Zhang N, Luo MH, Tao W, Wang H, Li J, Li J, Qiu BS, Zhou JN, Li X, Xu H, Wang K, Zhang X, Liu Y, Levin GR, Xu L, Zhang Z |
| 联系作者: | zhizhang@ustc.edu.cn |
| 发表年度: | 2019 |
| DOI: | doi: 10.1038/s41593-019-0468-2 |
| 摘要: | Comorbid depressive symptoms (CDS) in chronic pain are a common health problem, but the neural circuit mechanisms underlying these symptoms remain unclear. Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). The SOMCeAneurons project directly to the lateral habenula, an area known involved in depression. Inhibition of the 5-HTDRN→SOMCeA pathway produced depression-like behavior in a male mouse model of chronic pain. Activation of this pathway using pharmacological or optogenetic approaches reduced depression-like behavior in these mice. Human functional magnetic resonance imaging data showed that compared to healthy controls, functional connectivity between the CeA-containing centromedial amygdala and the DRN was reduced in patients with CDS but not in patients in chronic pain without depression. These findings indicate that a novel 5-HTDRN→SOMCeA→lateral habenula pathway may mediate at least some aspects of CDS |
| 刊物名称: | Nature Neuroscience |
| 论文出处: | https://www.nature.com/articles/s41593-019-0468-2 |
| 影响因子: | 21.126(2018年） |
