| 论文题目: | Genetic Basis of Ruminant Headgear and Rapid Antler Regeneration |
| 作者: | Wang Y, Zhang C, Wang N, Li Z, Heller R, Liu R, Zhao Y, Han J, Pan X, Zheng Z, Dai X, Chen C, Dou M, Peng S, Chen X, Liu J, Li M, Wang K, Liu C, Lin Z, Chen L, Hao F, Zhu W, Song C, Zhao C, Zheng C, Wang J, Hu S, Li C, Yang H, Jiang L, Li G, Liu M, Sonstegard TS, Zhang G, Jiang Y, Wang W, Qiu Q |
| 联系作者: | wwang@mail.kiz.ac.cn |
| 发表年度: | 2019 |
| DOI: | doi: 10.1126/science.aav6335 |
| 摘要: |
Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis |
| 刊物名称: | Science |
| 论文出处: | https://science.sciencemag.org/content/364/6446/eaav6335.long |
| 影响因子: | 41.037(2018年) |
