科研成果
获奖成果
论文
专著
专利
现在位置:首页 > 科研成果 > 论文
论文
论文题目: Platelets Mediate Protective Neuroinflammation and Promote Neuronal Plasticity at the Site of Neuronal Injury
作者: Dukhinova M, Kuznetsova I, Kopeykina E, Veniaminova E, Yung AWY, Veremeyko T, Levchuk K, Barteneva NS, Ho KKW, Yung WH, Liu JYH, Rudd J, Yau SSY, Anthony DC, Strekalova T, Ponomarev ED
联系作者: eponomarev@cuhk.edu.hk
发表年度: 2018
DOI: doi: 10.1016/j.bbi.2018.09.009
摘要:

It is generally accepted that inflammation within the CNS contributes to neurodegeneration after traumatic brain injury (TBI), but it is not clear how inflammation is initiated in the absence of infection and whether this neuroinflammation is predominantly beneficial or detrimental. We have previously found that brain-enriched glycosphingolipids within neuronal lipid rafts (NLR) induced platelet degranulation and secretion of neurotransmitters and pro-inflammatory factors. In the present study, we compared TBI-induced inflammation and neurodegeneration in wild-type vs. St3gal5 deficient (ST3-/-) mice that lack major CNS-specific glycosphingolipids. After TBI, microglial activation and CNS macrophage infiltration were substantially reduced in ST3-/- animals. However, ST3-/- mice had a larger area of CNS damage with marked neuronal/axonal loss. The interaction of platelets with NLR stimulated neurite growth, increased the number of PSD95-positive dendritic spines, and intensified neuronal activity. Adoptive transfer and blocking experiments provide further that platelet-derived serotonin and platelet activating factor plays a key role in the regulation of sterile neuroinflammation, hemorrhage and neuronal plasticity after TBI

刊物名称: Brain Behavior and Immunity
论文出处: https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(18)30578-6
影响因子: 6.306(2017年)