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论文题目: Genome Sequence of a Diabetes-prone Rodent Reveals a Mutation Hotspot Around the ParaHox Gene Cluster
作者: Hargreaves AD, Zhou L, Christensen J, Marlétaz F, Liu S, Li F, Jansen PG, Spiga E, Hansen MT, Pedersen SVH, Biswas S, Serikawa K, Fox BA, Taylor WR, Mulley JF, Zhang G, Heller RS, Holland PWH
联系作者: richardscottheller@gmail.com
发表年度: 2018
DOI: doi: 10.1073/pnas.1702930114
摘要:

The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHoxcluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution

刊物名称: Proceedings of the National Academy of Sciences of the United States of America
论文出处: http://www.pnas.org/content/114/29/7677.long
影响因子: (.661(2016年)