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论文题目: TET3-mediated DNA Oxidation Promotes ATR-dependent DNA Damage Response
作者: Jiang D, Wei S, Chen F, Zhang Y, Li J
联系作者: lijiali@mail.kiz.ac.cn
发表年度: 2018
DOI: doi: 10.15252/embr.201643179.
摘要:

An efficient, accurate, and timely DNA damage response (DDR) is crucial for the maintenance of genome integrity. Here, we report that ten-eleven translocation dioxygenase (TET) 3-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in response to ATR-dependent DDR regulates DNA repair. ATR-dependent DDR leads to dynamic changes in 5hmC levels and TET3 enzymatic activity. We show that TET3 is an ATR kinase target that oxidizes DNA during ATR-dependent DNA damage repair. Modulation of TET3 expression and activity affects DNA damage signaling and DNA repair and consequently cell death. Our results provide novel insight into ATR-mediated DDR, in which TET3-mediated DNA demethylation is crucial for efficient DNA repair and maintenance of genome stability

刊物名称: EMBO Reports
论文出处: http://embor.embopress.org/content/18/5/781.long
影响因子: 8.568(2016年)