科研成果
获奖成果
论文
专著
专利
现在位置:首页 > 科研成果 > 论文
论文
论文题目: Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis
作者: Liang H, Xiao J, Zhou Z, Wu J, Ge F, Li Z, Zhang H, Sun J, Li F, Liu R, Chen C
联系作者: chenc@mail.kiz.ac.cn
发表年度: 2018
DOI: doi: 10.1038/s41388-017-0089-8
摘要:

It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth factor A (VEGFA) axis to promote angiogenesis in breast cancer. However, it is unclear how this axis is negatively regulated. In this study, we demonstrated that miR-153 directly inhibits expression of HIF1α by binding to the 3'UTR of HIF1A mRNA, as well as suppresses tube formation of primary human umbilical vein endothelial cells (HUVECs) and breast cancer angiogenesis by decreasing the secretion of VEGFA. Importantly, expression of miR-153 was induced by hypoxia-stimulated ER stress, which activates IRE1α and its downstream transcription factor X-box binding protein 1 (XBP1). X-box binding protein 1 directly binds to the promoter of the miR-153 host gene PTPRN and activates transcription. These results indicate that hypoxia induces miR-153 to fine tune the HIF1α/VEGFA axis in breastcancer angiogenesis and miR-153 could be used for breast cancer anti-angiogenesis therapy

刊物名称: Oncogene
论文出处: https://www.nature.com/articles/s41388-017-0089-8
影响因子: 7.519(2016年)