|
论文 |
|
|
|
论文题目: |
Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium Complanatum |
作者: |
Zhang ZJ, Nian Y, Zhu QF, Li XN, Su J, Wu XD, Yang J, Zhao QS |
联系作者: |
qinshizhao@mail.kib.ac.cn |
发表年度: |
2017 |
DOI: |
doi:10.1021/acs.orglett.7b02293 |
摘要: |
Lycoplanine A (1), a Lycopodium alkaloid with a 6/9/5 tricyclic ring skeleton fused with the γ-lactone ring and featuring an unusual 1-oxa-6-azaspiro[4.4]nonane moiety and an unprecedented 3-azabicyclo[6.3.1]dodecane unit, was isolated from the club moss Lycopodium complanatum. The structure and absolute configuration of 1 were identified by a combination of NMR spectroscopic analysis and single-crystal X-ray diffraction. Biological studies showed that 1 is a potent Cav3.1 T-type calcium channel (TTCC) inhibitor with an IC50 value of 6.06 μM |
刊物名称: |
Organic Letters |
论文出处: |
http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.7b02293 |
影响因子: |
6.579(2016年) |
|
|