科研成果
获奖成果
论文
专著
专利
现在位置:首页 > 科研成果 > 论文
论文
论文题目: Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium Complanatum
作者: Zhang ZJ, Nian Y, Zhu QF, Li XN, Su J, Wu XD, Yang J, Zhao QS
联系作者: qinshizhao@mail.kib.ac.cn
发表年度: 2017
DOI: doi:10.1021/acs.orglett.7b02293
摘要:

Lycoplanine A (1), a Lycopodium alkaloid with a 6/9/5 tricyclic ring skeleton fused with the γ-lactone ring and featuring an unusual 1-oxa-6-azaspiro[4.4]nonane moiety and an unprecedented 3-azabicyclo[6.3.1]dodecane unit, was isolated from the club moss Lycopodium complanatum. The structure and absolute configuration of 1 were identified by a combination of NMR spectroscopic analysis and single-crystal X-ray diffraction. Biological studies showed that 1 is a potent Cav3.1 T-type calcium channel (TTCC) inhibitor with an IC50 value of 6.06 μM

刊物名称: Organic Letters
论文出处: http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.7b02293
影响因子: 6.579(2016年)