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论文 |
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| 论文题目: |
TET3-mediated DNA Oxidation Promotes
ATR-dependent DNA Damage Response |
| 作者: |
Jiang D, Wei S, Chen F, Zhang Y, Li J |
| 联系作者: |
lijiali@mail.kiz.ac.cn |
| 发表年度: |
2017 |
| DOI: |
doi:10.15252/embr.201643179 |
| 摘要: |
An efficient, accurate, and timely DNA damage response (DDR) is crucial for the maintenance of genome integrity. Here, we report that ten-eleven translocation dioxygenase (TET) 3-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in response to ATR-dependent DDR regulates DNA repair. ATR-dependent DDR leads to dynamic changes in 5hmC levels and TET3 enzymatic activity. We show that TET3 is an ATR kinase target that oxidizes DNA during ATR-dependent DNA damagerepair. Modulation of TET3 expression and activity affects DNA damage signaling and DNA repair and consequently cell death. Our results provide novel insight into ATR-mediated DDR, in which TET3-mediated DNA demethylation is crucial for efficient DNA repair and maintenance of genome stability |
| 刊物名称: |
EMBO reports |
| 论文出处: |
http：//embor.embopress.org/content/early/2017/03/21/embr.201643179 |
| 影响因子: |
7.739(2015年） |
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