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论文 |
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| 论文题目: |
(±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma Applanatum |
| 作者: |
Li L, Li H, Peng XR, Hou B, Yu MY, Dong JR, Li XN, Zhou L, Yang J, Qiu MH |
| 联系作者: |
jianyang@mail.kiz.ac.cn.; mhchiu@mail.kib.ac.cn. |
| 发表年度: |
2016 |
| DOI: |
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| 摘要: |
(±)-Ganoapplanin (1), a pair of novel meroterpenoid enantiomers featuring an unprecedented dioxaspirocyclic skeleton constructed from a 6/6/6/6 tetracyclic system and an unusual tricyclo[4.3.3.03',7']dodecane motif, were isolated from Ganoderma applanatum. Its structure and absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and ECD (electronic circular dichroism calculations). A plausible biogenetic pathway, involving a key Gomberg-Bachmann reaction, was also proposed for (±)-1. Biological studies showed that (±)-1 and its enantiomers exhibited different inhibitory activities on T-type voltage-gated calcium channels. |
| 刊物名称: |
Organic Letters |
| 论文出处: |
http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03064 |
| 影响因子: |
6.732 (2015年) |
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