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论文 |
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| 论文题目: |
BDNF Val66Met Polymorphism and Bipolar Disorder in European Populations: A risk Association in Case-control, Family-based and GWAS Studies |
| 作者: |
Li M, Chang H, Xiao X |
| 联系作者: |
limingkiz@mail.kiz.ac.cn |
| 发表年度: |
2016 |
| DOI: |
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| 摘要: |
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-like effects in animal models and may be implicated in the etiology of mood-related phenotypes. A functional polymorphism (Val66Met) in the BDNF gene was demonstrated to influence BDNF's secretion and function, as well as mood and cognitive related phenotypes. However, previous genetic association studies of Val66Metpolymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statisticalassociation or ancestry-specific effects. Here, we collected mood phenotypic and genetic data in over 90,000 individuals from diverse ethnic groups and conducted a systematic meta-analysis. The results showed that the Val66Met polymorphism was significantly associated with BPD in Europeans (Pmeta=0.0029, OR=1.136), but not in Asians (Pmeta=0.443). Also, it appears that the risk for MDD conferred by BDNF is waning, as the Val66Met variant was not associated with MDD in either European or Asian samples (Pmeta>0.5). |
| 刊物名称: |
Neuroscience and Biobehavioral Reviews |
| 论文出处: |
http://www.sciencedirect.com/science/article/pii/S0149763415303286 |
| 影响因子: |
8.580 (2015年) |
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