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论文 |
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| 论文题目: |
Evolution of the human-specific microRNA miR-941 |
| 作者: |
Hai Yang Hu; Liu He; Kseniya Fominykh; Zheng Yan; song Guo; Xiaoyu Zhang; martin s. Taylor; Lin Tang; Jie Li; Jianmei Liu; Wen Wang; Haijing Yu*; Philipp Khaitovich* |
| 联系作者: |
hjyu@ynu.edu.cn; khaitovich@eva.mpg.de |
| 发表年度: |
2012 |
| DOI: |
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| 摘要: |
MicroRNA-mediated gene regulation is important in many physiological processes. Here we explore the roles of a microRNA, miR-941, in human evolution. We find that miR-941 emerged de novo in the human lineage, between six and one million years ago, from an evolutionarily volatile tandem repeat sequence. Its copy-number remains polymorphic in humans and shows a trend for decreasing copy-number with migration out of Africa. Emergence of miR-941 was accompanied by accelerated loss of miR-941-binding sites, presumably to escape regulation. We further show that miR-941 is highly expressed in pluripotent cells, repressed upon differentiation and preferentially targets genes in hedgehog- and insulin-signalling pathways, thus suggesting roles in cellular differentiation. Human-specific effects of miR-941 regulation are detectable in the brain and affect genes involved in neurotransmitter signalling. Taken together, these results implicate miR-941 in human evolution, and provide an example of rapid regulatory evolution in the human linage. |
| 刊物名称: |
Nature Communications |
| 论文出处: |
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| 影响因子: |
11.329 (2015) |
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