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论文题目: Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea
作者: Cheng-Qin Liang; Yi-Ming Shi; Rong-Hua Luo; Xing-Yao Li; Zhong-Hua Gao; Xiao-Nian Li; Liu-Meng Yang; Shan-Zhai Shang; Yan Li; Yong-Tang Zheng; Hong-Bin Zhang; Wei-Lie Xiao*; Han-Dong Sun*
联系作者: xwl@mail.kib.ac.cn; hdsun@mail.kib.ac.cn
发表年度: 2012
DOI:
摘要: A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C-9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 mu g/mL, respectively.
刊物名称: Organic Letters
论文出处:
影响因子: 6.732 (2015)