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论文 |
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论文题目: |
Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea |
作者: |
Cheng-Qin Liang; Yi-Ming Shi; Rong-Hua Luo; Xing-Yao Li; Zhong-Hua Gao; Xiao-Nian Li; Liu-Meng Yang; Shan-Zhai Shang; Yan Li; Yong-Tang Zheng; Hong-Bin Zhang; Wei-Lie Xiao*; Han-Dong Sun* |
联系作者: |
xwl@mail.kib.ac.cn; hdsun@mail.kib.ac.cn |
发表年度: |
2012 |
DOI: |
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摘要: |
A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C-9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 mu g/mL, respectively. |
刊物名称: |
Organic Letters |
论文出处: |
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影响因子: |
6.732 (2015) |
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