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论文 |
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| 论文题目: |
Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain |
| 作者: |
Wei JK, Wang WC, Zhai RW, Zhang YH, Yang SC, Rizak J, Li L, Xu LQ, Liu L, Pan MK, Hu YZ, Ghanemi A, Wu J, Yang LC, Li H, Lv LB, Li JL, Yao YG, Xu L, Feng X, Yin Y, Qin DD, Hu XT, Wang ZB |
| 联系作者: |
xthu@mail.kiz.ac.cn;wangzb@mail.kiz.ac.cn |
| 发表年度: |
2016 |
| DOI: |
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| 摘要: |
Here, we examine whether neurons differentiated from transplanted stem cells can integrate into the host neural network and function in awake animals, a goal of transplanted stem cell therapy in the brain. We have developed a technique in which a small “hole” is created in the inferior colliculus (IC) of rhesus monkeys, then stem cells are transplanted in situ to allow for investigation of their integration into the auditory neural network. We found that some transplanted cells differentiated into mature neurons and formed synaptic input/output connections with the host neurons. In addition, c-Fos expression increased significantly in the cells after acoustic stimulation, and multichannel recordings indicated IC specific tuning activities in response to auditory stimulation. These results suggest that the transplanted cells have the potential to functionally integrate into the host neural network. |
| 刊物名称: |
Cell Reports |
| 论文出处: |
http://www.sciencedirect.com/science/article/pii/S221112471630835X |
| 影响因子: |
7.870 (2015年) |
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