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论文 |
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| 论文题目: |
KHF16 is a Leading Structure from Cimicifuga Foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway |
| 作者: |
Kong Y, Li F, Nian Y, Zhou Z, Yang R, Qiu MH, Chen CS |
| 联系作者: |
chenc@mail.kiz.ac.cn; qiuminghua@mail.kib.ac.cn;jenny_yrx@sohu.com. |
| 发表年度: |
2016 |
| DOI: |
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| 摘要: |
Triterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis. In this study, KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ERα/PR/HER2 triple-negative breast cancer (TNBC) cell lines. KHF16 significantly induces cell cycle G2/M phase arrest and apoptosis in both MDA-MB-468 and SW527 TNBC cell lines. KHF16 reduces the expression levels of XIAP, Mcl-1, Survivin and Cyclin B1/D1 proteins. Importantly, KHF16 inhibits TNFα-induced IKKα/β phosphorylation, IKBα phosphorylation, p65 nuclear translocation and NF-κB downstream target gene expression, including XIAP, Mcl-1 and Survivin, in TNBC cells. These results suggest that KHF16 may inhibit TNBC by blocking the NF-κB signaling pathway in part. |
| 刊物名称: |
Theranostics |
| 论文出处: |
http://www.thno.org/v06p0875.htm |
| 影响因子: |
8.854 (2015年) |
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