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论文 |
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| 论文题目: |
Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia Peplus |
| 作者: |
Wan LS, Nian Y, Ye CJ, Shao LD, Peng XR, Geng CA, Zuo ZL, Li XN, Yang J, Zhou M, Qiu MH |
| 联系作者: |
mhchiu@mail.kib.ac.cn; mingzhou@mail.kiz.ac.cn. |
| 发表年度: |
2016 |
| DOI: |
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| 摘要: |
Euphorbia peplus has been used in traditional medicine to treat asthma and psoriasis. Three highly modified diterpenoids, namely, pepluacetal (1) and pepluanol A-B (2-3), have been isolated and identified from this plant. Compounds 1-3 exhibit unprecedented 5/4/7/3, 5/6/7/3, and 5/5/8/3 ring systems, respectively. Their structures with absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and electronic circular dichroism calculations. Since Kv1.3 is a validated target for the treatment of autoimmune diseases, such as multiple sclerosis, type-1 diabetes, asthma, and psoriasis, Kv1.3 was studied in terms of its response to the new compounds. All three compounds inhibit Kv1.3, with compound 3 being the most effective with an IC50 value of 9.50 μM. |
| 刊物名称: |
Organic Letters |
| 论文出处: |
http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b00787 |
| 影响因子: |
6.364 (2014年) |
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