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论文 |
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| 论文题目: |
The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| 作者: |
Gui-Zhen Wang; Xin Cheng; Bo Zhou; Zhe-Sheng Wen; Yun-Chao Huang; Hao-Bin Chen; Gao-Feng Li; Zhi-Liang Huang; Yong-Chun Zhou; Lin Feng; Ming-Ming Wei; Li-Wei Qu; Yi Cao; Guang-Biao Zhou* |
| 联系作者: |
gbzhou@ioz.ac.cn |
| 发表年度: |
2015 |
| DOI: |
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| 摘要: |
More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province the lung cancer incidence is among the highest in China attributed to smoky coal combustion-generated PAH pollution. Here we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen bezo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in cxcl13 or its receptor, cxcr5, abrogated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis. |
| 刊物名称: |
Elife |
| 论文出处: |
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| 影响因子: |
9.322 (2014) |
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