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论文题目: Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine
作者: YongMei Sun; Wei Zong; MuRu Zhou; YuanYe Ma; JianHong Wang*
联系作者: wangjh@mail.kiz.ac.cn
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发表年度: 2015
卷: 135
期: X
页码: 60-63
摘要:

The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical mu receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine.

刊物名称: Pharmacology Biochemistry and Behavior
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影响因子: 2.781 (2014)
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