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论文题目: |
Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear |
作者: |
Zhou,Feng-Jiao; Nian,Yin; Yan,Yongming; Gong,Ye; Luo,Qi; Zhang,Yu; Hou,Bo; Zuo,Zhi-Li; Wang,Shu-Mei; Jiang,He-Hai; Yang,Jian; Cheng,Yong-Xian |
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发表年度: |
2015 |
卷: |
17 |
期: |
12 |
页码: |
3082-3085 |
摘要: |
T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Ca(v)3.1 TTCC and showed noticeable selectivity against Ca(v)1.2, Ca(v)2.1, Ca(v)2.2, and K(v)11.1 (hERG) channels. |
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影响因子: |
6.364 (2014) |
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