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论文题目: Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
作者: Zhou,Feng-Jiao; Nian,Yin; Yan,Yongming; Gong,Ye; Luo,Qi; Zhang,Yu; Hou,Bo; Zuo,Zhi-Li; Wang,Shu-Mei; Jiang,He-Hai; Yang,Jian; Cheng,Yong-Xian
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发表年度: 2015
卷: 17
期: 12
页码: 3082-3085
摘要: T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Ca(v)3.1 TTCC and showed noticeable selectivity against Ca(v)1.2, Ca(v)2.1, Ca(v)2.2, and K(v)11.1 (hERG) channels.
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影响因子: 6.364 (2014)
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