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论文题目: Processing of visually evoked innate fear by a non-canonical thalamic pathway
作者: Pengfei Wei; Nan Liu; Zhijian Zhang; Xuemei Liu; Yongqiang Tang; Xiaobin He; Bifeng Wu; Zheng Zhou; Yaohan Liu; Juan Li; Yi Zhang; Xuanyi Zhou; Lin Xu; Lin Chen; Guoqiang Bi; Xintian Hu; Fuqiang Xu; Liping Wang*
联系作者: lp.wang@siat.ac.cn
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发表年度: 2015
卷: 6
期: X
页码: e6756
摘要: The ability of animals to respond to life-threatening stimuli is essential for survival. Although vision provides one of the major sensory inputs for detecting threats across animal species, the circuitry underlying defensive responses to visual stimuli remains poorly defined. Here, we investigate the circuitry underlying innate defensive behaviours elicited by predator-like visual stimuli in mice. Our results demonstrate that neurons in the superior colliculus (SC) are essential for a variety of acute and persistent defensive responses to overhead looming stimuli. Optogenetic mapping revealed that SC projections to the lateral posterior nucleus (LP) of the thalamus, a non-canonical polymodal sensory relay, are sufficient to mimic visually evoked fear responses. In vivo electrophysiology experiments identified a di-synaptic circuit from SC through LP to the lateral amygdale (Amg), and lesions of the Amg blocked the full range of visually evoked defensive responses. Our results reveal a novel collicular-thalamic-Amg circuit important for innate defensive responses to visual threats.
刊物名称: Nature Communications
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影响因子: 11.470 (2014)
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