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论文题目: High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)(2)D-3 to increase NGF secretion in a rat Schwann cell line RSC96
作者: Yi-Kun Zhou; Zhi Liang; Yan Guo; Hua-Tang Zhang; Kun-Hua Wang
联系作者: hua64482@sina.com;zht79571@163.com
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发表年度: 2015
卷: 404
期: C
页码: 75-81
摘要: Vitamin D deficiency or insufficiency is an independent risk factor for diabetic peripheral neuropathy (DPN), but the relationship between 1,25(OH)(2)D-3 and DPN remains unknown. We found that 1,25(OH)(2)D-3 stimulated the secretion of nerve growth factor (NGF) in rat Schwann cell line RSC96, but ability of 1,25(OH)(2)D-3 to increase NGF protein was impaired under high glucose conditions. High glucose upregulated the expression of CYP24A1 protein, which catalyzes the conversion of 1,25(OH)(2)D-3 into inactive products, further impairing the ability of 1,25(OH)(2)D-3 to upregulate NGF secretion in Schwann cells. Inhibition of CYP24A1 protein expression ameliorated the secretion of NGF in response to 1,25(OH)(2)D-3. The findings of this study suggest that CYP24A1 protein plays an important role in the relationship between DPN and 1,25(OH)(2)D-3.
刊物名称: Molecular and Cellular Endocrinology
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影响因子: 4.405 (2014)
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