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论文题目: |
High glucose upregulates CYP24A1 expression which attenuates the ability of 1,25(OH)(2)D-3 to increase NGF secretion in a rat Schwann cell line RSC96 |
作者: |
Yi-Kun Zhou; Zhi Liang; Yan Guo; Hua-Tang Zhang; Kun-Hua Wang |
联系作者: |
hua64482@sina.com;zht79571@163.com |
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发表年度: |
2015 |
卷: |
404 |
期: |
C |
页码: |
75-81 |
摘要: |
Vitamin D deficiency or insufficiency is an independent risk factor for diabetic peripheral neuropathy (DPN), but the relationship between 1,25(OH)(2)D-3 and DPN remains unknown. We found that 1,25(OH)(2)D-3 stimulated the secretion of nerve growth factor (NGF) in rat Schwann cell line RSC96, but ability of 1,25(OH)(2)D-3 to increase NGF protein was impaired under high glucose conditions. High glucose upregulated the expression of CYP24A1 protein, which catalyzes the conversion of 1,25(OH)(2)D-3 into inactive products, further impairing the ability of 1,25(OH)(2)D-3 to upregulate NGF secretion in Schwann cells. Inhibition of CYP24A1 protein expression ameliorated the secretion of NGF in response to 1,25(OH)(2)D-3. The findings of this study suggest that CYP24A1 protein plays an important role in the relationship between DPN and 1,25(OH)(2)D-3. |
刊物名称: |
Molecular and Cellular Endocrinology |
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影响因子: |
4.405 (2014) |
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