 |
论文 |
|
|
 |
| 论文编号: |
|
| 论文题目: |
The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques |
| 作者: |
Wang, Rui-Rui; Au, Ka-Yee; Zheng, Hong-Yi; Gao, Liang-Min; Zhang, Xuan;Luo, Rong-Hua; Law, Sue Ka-Yee; Mak, Amanda Nga-Sze; Wong, Kam-Bo;Zhang, Ming-Xu; Pang, Wei; Zhang, Gao-Hong; Shaw, Pang-Chui; Zheng,Yong-Tang |
| 联系作者: |
pcshaw@cuhk.edu.hk; zhengyt@mail.kiz.ac.cn |
| 外单位作者单位: |
|
| 发表年度: |
2015 |
| 卷: |
7 |
| 期: |
1 |
| 页码: |
156-169 |
| 摘要: |
Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions. |
| 刊物名称: |
Toxins |
| 论文全文: |
点击查看 |
| 全文链接: |
点击下载 |
| Email:: |
|
| 学科: |
|
| 影响因子: |
3.571 (20150 |
| 第一作者所在部门: |
|
| 论文出处: |
|
| 论文类别: |
|
| 参与作者: |
|
|
|
