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论文题目: Pleiotropy of the de novo-originated gene MDF1
作者: Dan Li; Zhihui Yan; Lina Lu; Huifeng Jiang*; Wen Wang*
联系作者: jiang_hf@tib.cas.cn;wwang@mail.kiz.ac.cn
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发表年度: 2014
卷: 4
期: X
页码: e7280
摘要: MDF1 is a young de novo-originated gene from a non-coding sequence in baker's yeast, S. cerevisiae, which can suppress mating and promote vegetative growth. Our previous experiments successfully demonstrated how Mdf1p binds to the key mating pathway determinant MAT alpha 2 to suppress mating. However, how Mdf1p promotes growth and fulfills the crosstalk between the yeast mating and growth pathways are still open questions. Thus, the adaptive significance of this new de novo gene remains speculative. Here, we show that Mdf1p shortens the lag phase of S. cerevisiae by physically interacting with SNF1, the governing factor for nonfermentable carbon source utilization, and thereby confers a selective advantage on yeasts through the rapid consumption of glucose in the early generational stage in rich medium. Therefore, MDF1 functions in two important molecular pathways, mating and fermentation, and mediates the crosstalk between reproduction and vegetative growth. Together, our results provide a comprehensive example of how a de novo-originated gene organizes new regulatory circuits and thereby confers a selective advantage on S. cerevisiae to allow exquisite adaptation to the changing environment.
刊物名称: Scientific Reports
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影响因子: 5.578 (2014)
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