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论文题目: Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism
作者: Qingyu Zhang; Jie Liu; Bin Liu; Juan Xia; Nianping Chen; Xiaofeng Chen; Yi Cao; Chen Zhang; CaiJie Lu; Mingyi Li*; Runzhi Zhu*
联系作者: Limingyi63@yahoo.cn; hepatolab@gmail.com
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发表年度: 2014
卷: 4
期: X
页码: e4628
摘要: The development of antitumor chemotherapy drugs remains a key goal for oncologists, and natural products provide a vast resource for anti-cancer drug discovery. In the current study, we found that the flavonoid dihydromyricetin (DHM) exhibited antitumor activity against liver cancer cells, including primary cells obtained from hepatocellular carcinoma (HCC) patients. In contrast, DHM was not cytotoxic to immortalized normal liver cells. Furthermore, DHM treatment resulted in the growth inhibition and remission of xenotransplanted tumors in nude mice. Our results further demonstrated that this antitumor activity was caused by the activation of the p53-dependent apoptosis pathway via p53 phosphorylation at serine (15Ser). Moreover, our results showed that DHM plays a dual role in the induction of cell death when administered in combination with cisplatin, a common clinical drug that kills primary hepatoma cells but not normal liver cells.
刊物名称: Scientific Reports
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影响因子: 5.228 (2015)
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