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| 论文编号: |
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| 论文题目: |
Cucurbitacin e induces cell cycle g2/m phase arrest and apoptosis in triple negative breast cancer. |
| 作者: |
Kong, Yanjie; Chen, Jianchao; Zhou, Zhongmei; Xia, Houjun; Qiu, Ming-Hua; Chen, Ceshi |
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| 发表年度: |
2014 |
| 卷: |
9 |
| 期: |
7 |
| 页码: |
e103760 |
| 摘要: |
Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics. |
| 刊物名称: |
Plos One |
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| 影响因子: |
3.534 |
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