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| 论文编号: |
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| 论文题目: |
Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals |
| 作者: |
Zhen Liu; Wei Wang; Tong-Zuo Zhang; Gong-Hua Li, Kai He; Jing-Fei Huang; Xue-Long Jiang; Robert W. Murphy; Peng Shi* |
| 联系作者: |
ship@mail.kiz.ac.cn |
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| 发表年度: |
2014 |
| 卷: |
281 |
| 期: |
1776 |
| 页码: |
e20132950 |
| 摘要: |
Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals. |
| 刊物名称: |
Proceedings of the Royal Society B-biological Sciences |
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| 影响因子: |
4.823 (2015) |
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