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Principal Investigator
Neurogenomics
Lei Shi   Ph.D  
Title Professor
Phone +86 871 65190167
Fax
E-mail shilei@mail.kiz.ac.cn
Address 17 Longxin Rd. Kunming, Yunnan 650201, P.R. China
Zip Code 650201
 
   CURRICULUM VITAE

2012.07   Ph.D. (Laboratory of Bing Su), State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P.R. China

2007.07  B.S. in College of Life Sciences, Southwest University, Chongqing, P.R. China

 

2020.10-Now    Principal Investigator (Neurogenomics Lab), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P.R. China.

2019.03-2020.09   Postdoctoral Fellow (Laboratory of Juan Carlos Izpisua Belmonte), Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, USA.

2015.07-2019.03  Postdoctoral Research Fellow (Laboratory of Kenneth Y. Kwan), Molecular &Behavioral Neuroscience Institute (MBNI), University of Michigan, Ann Arbor, USA.

2012.09-2015.07   Research Associate (Laboratory of Bing Su), State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P.R. China

2013.01-2013.07   Visiting Scholar (Laboratory of Martin Styner) Psychiatry Department, University of North Carolina, Chapel Hill, USA.

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  Selected Publications:

1.       Browder, K. C., Reddy, P., Yamamoto, M., Haghani, A., Guillen, I. G., Sahu, S., Wang, C., Luque, Y., Prieto, J., Shi, L., Shojima, K., Hishida, T., Lai, Z., Li, Q., Choudhury, F. K., Wong, W. R., Liang, Y., Sangaraju, D., Sandoval, W., Esteban, C. R., Delicado, E. N., Garcia, P. G., Pawlak, M., Vander Heiden, J. A., Horvath, S., Jasper, H. & Izpisua Belmonte, J. C. (2022). In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nature Aging.2, 243-253.

2.       Liu, H., Li, R., Liao, H.-K., Min, Z., Wang, C., Yu, Y., Shi, L., Dan, J., Hayek, A., Martinez Martinez, L., Nu?ez Delicado, E. & Izpisua Belmonte, J. C. (2021) Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells. Nature Communications. 12, 3330.

3.       Wang, C., Rabadan Ros, R., Martinez-Redondo, P., Ma, Z., Shi, L., Xue, Y., Guillen-Guillen, I., Huang, L., Hishida, T., Liao, H.-K., Nu?ez Delicado, E., Rodriguez Esteban, C., Guillen-Garcia, P., Reddy, P. & Izpisua Belmonte, J. C. (2021) In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. Nature Communications 12, 3094.

4.       Keil, J.M., Doyle, D.Z., Qalieh, A., Lam, M.M., Funk, O.H., Qalieh, Y., Shi, L., Mohan, N., Sorel, A., and Kwan, K.Y. (2020). Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications 11, 3839.

5.       Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H. K., Qiao, J., Deng, H., Nunez-Delicado, E., Rodriguez Esteban, C., Wu, J. and Izpisua Belmonte, J. C. (2019). Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell 179 (3), 687-702.

6.       Shi, L., Qalieh, A., Lam, M. M., Keil, J. M., and Kwan, K. Y. (2019). Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nature Communications 10 (1):2588

7.       Shi, L., and Su, B. (2019). A transgenic monkey model for the study of human brain evolution. Zoological Research 40 (3):236-38

8.       Shi, L#., Luo, X#., Jiang, J#., Chen, Y#., Liu, C#., Hu, T., Li, M., Lin, Q., Li, Y., Huang, J., Wang, H., Niu, Y., Shi, Y., Styner, M., Wang, J., Lu, Y., Sun, X., Yu, H., Ji, W., and Su, B. (2019). Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review 6 (3):480-93

9.       Shi, L#., Hu, E. Z#., Wang, Z. B#., Liu, J. W., Li, J., Li, M., Chen, H., Yu, C. S., Jiang, T. Z., and Su, B. (2017). Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution. Human Genetics 136 (2):193-204

10.   Mendizabal, I#., Shi, L#., Keller, T. E., Konopka, G., Preuss, T. M., Hsieh, T. F., Hu, E. Z., Zhang, Z., Su, B., and Yi, S. V. (2016). Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution. Molecular Biology and Evolution 33 (11):2947-59

11.   Shi, L#., Zhang, Z#., and Su, B. (2016). Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages. Scientific Reports 6

12.   Shi, L., Lin, Q., and Su, B. (2015). Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates. BMC Evol Biol 15:127

13.   Shi, L#., Lin, Q#., and Su, B. (2014). Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator. Molecular Biology and Evolution 31 (3):594-604

14.   Shi, L., Li, M., Lin, Q., Qi, X. B., and Su, B. (2013). Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans. BMC Biology 11

15.   Niu, Y. Y., Yu, Y., Bernat, A., Yang, S. H., He, X. C., Guo, X. Y., Chen, D. L., Chen, Y. C., Ji, S. H., Si, W., Lv, Y. Q., Tan, T., Wei, Q. A., Wang, H., Shi, L., Guan, J. A., Zhu, X. M., Afanassieff, M., Savatier, P., Zhang, K., Zhou, Q., and Ji, W. Z. (2010). Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. PNAS 107 (41):17663-67

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