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Principal Investigator
Lei Shi     
Title
Phone +86 871 65190167
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E-mail shilei@mail.kiz.ac.cn
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Zip Code 650201
 
   Education and Appointments:
 
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  Selected Publications:

 1. Keil, J.M., Doyle, D.Z., Qalieh, A., Lam, M.M., Funk, O.H., Qalieh, Y., Shi, L., Mohan, N., Sorel, A., and Kwan, K.Y. (2020). Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications 11, 3839. 

2.  Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., et al. (2019). Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell 179, 687-702 

3.  Shi, L., Qalieh, A., Lam, M. M., Keil, J. M., and Kwan, K. Y. (2019). Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nature Communications 10 (1):2588 

4.  Shi, L., and Su, B. (2019). A transgenic monkey model for the study of human brain evolution. Zoological Research 40 (3):236-38 

5.  Shi, L.#, Luo, X.#, Jiang, J.#, Chen, Y.#, Liu, C.#, Hu, T., Li, M., Lin, Q., Li, Y., Huang, J., Wang, H., Niu, Y., Shi, Y., Styner, M., Wang, J., Lu, Y., Sun, X., Yu, H., Ji, W., and Su, B. (2019). Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review 6 (3):480-93#co-first author 

6.  Shi, L.#, Hu, E. Z.#, Wang, Z. B.#, Liu, J. W., Li, J., Li, M., Chen, H., Yu, C. S., Jiang, T. Z., and Su, B. (2017). Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution. Human Genetics 136 (2):193-204#co-first author 

7.  Mendizabal, I.#, Shi, L.#, Keller, T. E., Konopka, G., Preuss, T. M., Hsieh, T. F., Hu, E. Z., Zhang, Z., Su, B.*, and Yi, S. V.* (2016). Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution. Molecular Biology and Evolution 33 (11):2947-59 #co-first author 

8.  Shi, L.#, Zhang, Z.#, and Su, B. (2016). Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages. Scientific Reports 6#co-first author 

9.  Shi, L., Lin, Q., and Su, B. (2015). Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates. BMC Evol Biol 15:127 

10.  Shi, L.#, Lin, Q.#, and Su, B. (2014). Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator. Molecular Biology and Evolution 31 (3):594-604#co-first author 

11.  Li, M., Luo, X. J., Rietschel, M., Lewis, C. M., Mattheisen, M., Muller-Myhsok, B., Jamain, S., Leboyer, M., Landen, M., Thompson, P. M., Cichon, S., Nothen, M. M., Schulze, T. G., Sullivan, P. F., Bergen, S. E., Donohoe, G., Morris, D. W., Hargreaves, A., Gill, M., Corvin, A., Hultman, C., Toga, A. W., Shi, L., Lin, Q., Shi, H., Gan, L., Meyer-Lindenberg, A., Czamara, D., Henry, C., Etain, B., Bis, J. C., Ikram, M. A., Fornage, M., Debette, S., Launer, L. J., Seshadri, S., Erk, S., Walter, H., Heinz, A., Bellivier, F., Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Franke, B., Martin, N. G., Wright, M. J., Su, B., Consortium, M. B., Group, S. B. S., Neuroimaging, A. s. D., Consortium, E., and Consortium, C. (2014). Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry 19 (4):452-61 

12.  Shi, L., Li, M., Lin, Q., Qi, X. B., and Su, B. (2013). Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans. BMC Biology 11 

13.  Li, M., Luo, X. J., Xiao, X., Shi, L., Liu, X. Y., Yin, L. D., Ma, X. Y., Yang, S. Y., Pu, X. F., Yu, J., Diao, H. B., Shi, H., and Su, B. (2013). Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population. World Journal of Biological Psychiatry 14 (2):91-99 

14.  Shi, L., and Su, B. (2012). Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression. FEBS Journal 279 (3):491-503 

15.  Shi, L., Li, M., and Su, B. (2012). MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene. Gene 495 (1):1-9 

16.  Li, M., Luo, X. J., Xiao, X., Shi, L., Liu, X. Y., Yin, L. D., Diao, H. B., and Su, B. (2011). Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia. American Journal of Psychiatry 168 (12):1318-25 

17.  Li, M., Mo, Y., Luo, X. J., Xiao, X., Shi, L., Peng, Y. M., Qi, X. B., Liu, X. Y., Yin, L. D., Diao, H. B., and Su, B. (2011). Genetic association and identification of a functional SNP at GSK3 beta for schizophrenia susceptibility. Schizophrenia Research 133 (1-3):165-71 

18.  Niu, Y. Y., Yu, Y., Bernat, A., Yang, S. H., He, X. C., Guo, X. Y., Chen, D. L., Chen, Y. C., Ji, S. H., Si, W., Lv, Y. Q., Tan, T., Wei, Q. A., Wang, H., Shi, L., Guan, J. A., Zhu, X. M., Afanassieff, M., Savatier, P., Zhang, K., Zhou, Q., and Ji, W. Z. (2010). Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America 107 (41):17663-67 

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