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| Spatial Cognition and Neurological Disorders |
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| E-mail |
luli@mail.kiz.ac.cn |
| Address |
No.17 Longxin Road, Kunming 650201, Yunnan, China |
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08/2015, Faculty of Medicine, Norwegian University of Science and Technology (Norges Teknisk-Naturvitenskapelige Universitet, NTNU), Ph.D in Neuroscience, Supervisors: Prof. Dr. Edvard I. Moser & Prof. Dr. May-Britt Moser (2014 Nobel laureates in Physiology or Medicine), Trondheim, Norway.
04/2007, University of Heidelberg (Universit？t Heidelberg), Master of Science in Molecular Biosciences, Supervisor: Prof. Dr. Hilmar Bading, Heidelberg, Germany.
07/2005, College of Life Sciences, Peking University, Bachelor of Science in Biological Science, Beijing, China.
10/2019 – present, Kunming Institute of Zoology, Chinese Academy of Sciences, Principal investigator, Kunming, China.
04/2016 – 09/2019, Department of Neurosciences, Baylor College of Medicine, Postdoc associate, Supervisors: Prof. Dr. Dora E. Angelaki & Prof. Dr. J. David Dickman, Houston, USA.
09/2015 – 03/2016, Kavli Institute for Systems Neuroscience / Centre for Neural Computation, Faculty of Medicine, NTNU, Researcher (Postdoc), Supervisors: Prof. Dr. Edvard Moser and Prof. Dr. May-Britt Moser, Trondheim, Norway.
05/2007 – 02/2009, Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Research assistant (technician), Supervisor: Prof. Dr. Hilmar Bading, Heidelberg, Germany.
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Spatial cognition, which enables an individual to navigate the environment in an oriented way, is vital to animals’ everyday survival. Deficits in spatial navigation skills are often preclinical signs of Alzheimer’s disease in seniors and neurodevelopmental disorders in children and adolescents. How the brain encode cognitive maps, which are internal representations of external space acquired through integration of multisensory cues, and how the brain utilize cognitive maps to guide navigational behavior remain elusive. Starting from October 2019, our group is interested in the coding schemes of the hippocampal-entorhinal circuit, which plays a critical role in spatial cognition. We are particularly interested in how three-dimensional space is reflected in the firing patterns of hippocampal and entorhinal neurons. We use in vivo extracellular recording techniques to monitor the activities of hippocampal place cells while rats or tree-shrews are performing navigational tasks, try to reveal: a) how spatial and non-spatial information is coded in cognitive maps, and b) how they influence flexible navigational strategies during complicated tasks.
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National Science and Technology Innovation 2030 Major Program, 2022-2027.
National Natural Science Foundation of China, General Program, 2020-2023.
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Human Frontier Science Program Fellowship 2016-2019
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1. Long JL, Lu L. 2022. Dynamic coding in the hippocampus during navigation. Zoological Research, 43(6), 1023-1025.
2. Gofman X, Tocker G, Weiss S, Boccara CN, Lu L, Moser MB, Moser EI, Morris G, Derdikman D. 2019. Dissociation between Postrhinal Cortex and Downstream Parahippocampal Regions in the Representation of Egocentric Boundaries. Current Biology. 29(16), 2751-2757.
3. Gardner RJ, Lu L, Wernle T, Moser MB, Moser EI. 2019. Correlation structure of grid cells is preserved during sleep. Nature Neuroscience. 22(4), 598-608.
4. Tsao A, Sugar J, Lu L, Wang C, Knierim JJ, Moser MB, Moser EI. 2018. Integrating time from experience in the lateral entorhinal cortex. Nature. 561(7721), 57-62.
5. Lu L, Popeney B, Dickman JD, Angelaki DE. 2018. Construction of an Improved Multi-Tetrode Hyperdrive for Large-Scale Neural Recording in Behaving Rats. Journal of Visualized Experiments. (135).
6. Lu L, Igarashi KM, Witter MP, Moser EI, Moser MB. 2015. Topography of Place Maps along the CA3-to-CA2 Axis of the Hippocampus. Neuron. 87(5), 1078-1092.
7. Igarashi KM, Lu L, Colgin LL, Moser MB, Moser EI. 2014. Coordination of entorhinal-hippocampal ensemble activity during associative learning. Nature. 510(7503), 143-147.
8. Lu L, Leutgeb JK, Tsao A, Henriksen EJ, Leutgeb S, Barnes CA, Witter MP, Moser MB, Moser EI. 2013. Impaired hippocampal rate coding after lesions of the lateral entorhinal cortex. Nature Neuroscience. 16(8), 1085-1093.
9. Zhang SJ, Zou M, Lu L, Lau D, Ditzel DA, Delucinge-Vivier C, Aso Y, Descombes P, Bading H. 2009. Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. PLoS Genetetics. 5(8).
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Name: Li, Chengji
Job: Title Lab manager
Tel.: 15812067649
Email: lichengji@mail.kiz.ac.cn
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