#32 Jiaochangdong Road, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
Education and Appointments：
Neng-Yin Sheng, Ph.D, Professor & Principal Investigator
2017.08 – Present: Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences
2011.8 – 2017.07: Postdoctoral Fellow, University of California, San Francisco, Department of Cellular and Molecular Pharmacology
2003.09 –2011.01: PhD, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1999.09 –2003.07: B.S. Nankai University
Synapses are the primary functional units for neuronal communication in the brain and many neurodegeneration and neurological diseases are ultimately attributed to their malfunction or pathology. The long-term goal of my lab is to study the physiological and pathological roles and mechanisms of synapse for our brain functions, combing the electrophysiological method with novel molecular and genetic tools and biochemical, molecular, developmental biological approaches. The current research directions are as following:
(1) The molecular mechanisms of synaptic organization, synaptic transmission, synaptic plasticity;
(2) The molecular bases for synaptic malfunction underlying neurological diseases;
(3) The unique synaptic properties of human and primate central nervous system during development and neural transmission.
1.Duan GF, Ye Y, Xu S, Tao W, Zhao S, Jin T, Nicoll RA, Shi YS*, Sheng N*. (2018) Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nature Communications 9:4879.
2.Sheng N*, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA*. (2018) LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. Proceedings of the National Academy of Sciences 115: 3948-3953.
3.Tao W, Díaz-Alonso J, Sheng N, Roger A. Nicoll. (2018) Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin. Proceedings of the National Academy of Sciences 115: E5373-E5381.
4.Lomash RM, Sheng N, Li Y, Nicoll RA, Roche KW. (2017) Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at Serine 409 regulates synaptic targeting of the KAR subunit GluK1. Journal of Biological Chemistry 292:15369-15377.
5.Sheng N, Shi YS, Nicoll RA. (2017) Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking. Proceedings of the National Academy of Sciences 114: 1159-1164.
6.Sheng N, Yang J, Silm K, Edwards RH, Nicoll RA. (2017) A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons. Neuropharmacology 115: 4-9.
7.Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll RA. (2015) Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. Elife 3: e11682.
8.Yue W, Li Y, Zhang T, Jiang M, Qian Y, Zhang M, Sheng N, Feng S, Tang K, Yu X, Shu Y, Yue C, Jing N. (2015) ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models. Stem Cell Reports 5: 776-90.
9.Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han JD, Li J, Jing N. (2014) The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. Elife 3: e02224.
10. Fu Y, Tucciarone JM, Espinosa JS, Sheng N, Darcy DP, Nicoll RA, Huang ZJ, Stryker MP. (2014) A cortical circuit for gain control by behavioral state. Cell 156: 1139-1152.
11. Qiao Y, Zhu Y, Sheng N, Chen J, Tao R, Zhu Q, Zhang T, Qian C, Jing N. (2012) AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning. Cell Research 22: 1546–1561.
12. Xie Z, Sheng N, Jing N. (2012) BMP signaling pathway and spinal cord development. Frontiers in Biology 7: 24-29. (Review)
13. Sheng N, Xie Z, Wang C, Bai G, Zhang K, Zhu Q, Song J, Guillemot F, Chen YG, Lin A, Jing N. (2010) Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proceedings of the National Academy of Sciences 107: 18886-18891.
14. Hu Z, Wang C, Xiao Y, Sheng N, Chen Y, Xu Y, Zhang L, Mo W, Jing N, Hu G. (2009) NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development. Journal of Cell Science 122: 1145-1154.
15. Jing N, Sheng N, Xie Z. (2009) The function of BMP signaling pathway during the central nervous system development. Chinese Journal of Cell Biology 31: 2-8.
16. Bai G, Sheng N, Xie Z, Bian W, Yokota Y, Benezra R, Kageyama R, Guillemot F, Jing N. (2007) Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Developmental Cell 13: 283-297.