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Principal Investigator
Ming Li     
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Phone +86 871 65189508
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E-mail limingkiz@mail.kiz.ac.cn
Address #32 Jiaochangdong Road, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
Zip Code 650201
 
   CURRICULUM VITAE
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中科院和云南省“动物模型与人类疾病机理”重点实验室项目(50万元) 

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  Selected Publications:

1.       Yin MY, Guo L, Zhao LJ, Zhang C, Liu WP, Zhang CY, Huo JH, Wang L, Li SW, Zheng CB, Xiao X, Li M, Wang C, Chang H. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. BMC Medicine 2023;21:256.

2.       Yang ZH, Cai X, Ding ZL, Li W, Zhang CY, Huo JH, Zhang Y, Wang L, Zhang LM, Li SW, Li M, Zhang C, Chang H, Xiao X. Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. BMC Medicine 2023;21:254.

3.       Wu Y, Zhang CY, Wang L, Li Y, Xiao X. Genetic insights of schizophrenia via single cell RNA-sequencing analyses. Schizophrenia Bulletin 2023;49:914-922.

4.       Qi HX, Xiao X, Li T, Li M. New "drugs and targets" in the GWAS era of bipolar disorder. Bipolar Disorders 2023;25(5):410-421.

5.       Zhang CY, Cai X, Guo L, Wang L, Liu Z, Luo XJ, Li M, GeseDNA Research Team, Wang C, Li T, Xiao X. Genetic evidence for the "dopamine hypothesis of bipolar disorder". Molecular Psychiatry 2023;28:532-535.

6.       Shang MY, Wu Y, Zhang CY, Qi HX, Zhang Q, Huo JH, Wang L, Wang C, Li M. Bidirectional genetic overlap between bipolar disorder and intelligence. BMC Medicine 2022;20:464.

7.       Sun P, Wang L, Yang Y, Zhang CY, Yang L, Fang Y, Li M. Common variants associated with AKAP11 expression confer risk of bipolar disorder. Asian Journal of Psychiatry 2022;77:103271.

8.      Li M, Li T, Xiao X, Chen J, Hu Z, Fang Y. Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings. Molecular Psychiatry 2022;27:2927-2939.

9.       Xiao X, Zhang CY, Zhang Z, Hu Z, Li M, Li T. Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution. Molecular Psychiatry 2022;27:466-475.

10.    Zhang CY, Xiao X, Zhang Z, Hu Z, Li M. An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data. Molecular Psychiatry 2022;27:95-112.

11.   Chen R, Yang Z, Liu J, Cai X, Huo Y, Zhang Z, Li M, Chang H, Luo XJ. Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants. Genome Medicine 2022;14:53.

12.    Zhang Y, Zhang CY, Yuan J, Zeng XZ, Zhai SS, Xiao X, Li M, Yang JZ. Epistatic interactions of NRG1 and ERBB4 on antipsychotic treatment response in first-episode schizophrenia patients. Schizophrenia Research 2022;241:197-200.

13.   Li HJ, Zhang C, Hui L, Zhou DS, Li Y, Zhang CY, Wang C, Wang L, Li W, Yang Y, Qu N, Tang J, He Y, Zhou J, Yang Z, Li X, Cai J, Yang L, Chen J, Fan W, Tang W, Tang W, Jia QF, Liu W, Zhuo C, Song X, Liu F, Bai Y, Zhong BL, Zhang SF, Chen J, Xia B, Lv L, Liu Z, Hu S, Li XY, Liu JW, Cai X, Yao YG, Zhang Y, Yan H, Chang S, Zhao JP, Yue WH, Luo XJ, Chen X, Xiao X, Fang Y, Li M, for the GeseDNA Research Team. Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: A genome-wide association study and meta-analysis. JAMA Psychiatry 2021;78:320-330.

14.   Chang H, Cai X, Li HJ, Liu WP, Zhao LJ, Zhang CY, Wang JY, Liu JW, Ma XL, Wang L, Yao YG, Luo XJ, Li M, Xiao X. Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus. Biological Psychiatry 2021;89:246-255. (Cover story)

15.   Chang H, Cai X, Yang ZH, Xiao X, Li M. Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions. Molecular Psychiatry 2021;26:6109-6111.

16.   Zhang C, Xiao X, Li T, Li M. Translational genomics and beyond in bipolar disorder. Molecular Psychiatry 2021;26:186-202.

17.   Cao X, Liu WP, Cheng L, Li HJ, Wu H, Liu Y, Chen C, Xiao X, Li M, Wang GD, Zhang YP. Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs. Science Bulletin 2021;66:187-196.

18.   Cai X, Yang ZH, Li HJ, Xiao X, Li M, Chang H. A human-specific schizophrenia risk tandem repeat affects alternative splicing of a human-unique isoform AS3MTd2d3 and mushroom dendritic spine density. Schizophrenia Bulletin 2021;41:219-227.

19.    Li W, Cai X, Li HJ, Song M, Zhang CY, Yang Y, Zhang L, Zhao L, Liu W, Wang L, Shao M, Zhang Y, Zhang C, Cai J, Zhou DS, Li X, Hui L, Jia QF, Qu N, Zhong BL, Zhang SF, Chen J, Xia B, Li Y, Song X, Fan W, Tang W, Tang W, Tang J, Chen X, Yue W, Zhang D, Fang Y, Xiao X, Li M, Lv L, Chang H. Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. Neuropsychopharmacology 2021;46:1103-1112.

20.   Yang Z, Zhou D, Li H, Cai X, Liu W, Wang L, Chang H, Li M, Xiao X. The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function and mushroom dendritic spine. Molecular Psychiatry 2020;25:48-66.

21.   Li H, Zhang C, Cai X, Wang L, Luo F, Ma Y, Li M, Xiao X. Genome-wide association study of creativity reveals genetic overlap with psychiatric disorders, risk tolerance, and risky behaviors. Schizophrenia Bulletin 2020;46:1317-1326.

22.   Liu W, Li W, Cai X, Yang Z, Li H, Su X, Song M, Zhou DS, Li X, Zhang C, Shao M, Zhang L, Yang Y, Zhang Y, Zhao J, Chang H, Yao YG, Fang Y, Lv L, Li M, Xiao X. Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci. Neuropsychopharmacology 2020;45:1196-1206.

23.    Li HJ, Su X, Zhang L, Zhang CY, Wang L, Li W, Yang Y, Lv L, Li M, Xiao X. Transcriptomic analyses of humans and mice provide insights into depression. Zoological Research 2020;41:632-643.

24.    Yang ZH, Cai X, Qu N, Zhao LJ, Zhong BL, Zhang SF, Chen J, Xia B, Jiang HY, Zhou DY, Liu WP, Chang H, Xiao X, Li Y, Li M. Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32. Zoological Research 2020;41:84-89.

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