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Principal Investigator
Ming Li     
Title
Phone +86 871 65189508
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E-mail limingkiz@mail.kiz.ac.cn
Address #32 Jiaochangdong Road, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
Zip Code 650201
 
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中科院和云南省“动物模型与人类疾病机理”重点实验室项目(50万元) 

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  Selected Publications:

 

1.        Li HJ,# Zhang C,# Hui L,# Zhou DS,# Li Y,# Zhang CY,# Wang C, Wang L, Li W, Yang Y, Qu N, Tang J, He Y, Zhou J, Yang Z, Li X, Cai J, Yang L, Chen J, Fan W, Tang W, Tang W, Jia QF, Liu W, Zhuo C, Song X, Liu F, Bai Y, Zhong BL, Zhang SF, Chen J, Xia B, Lv L, Liu Z, Hu S, Li XY, Liu JW, Cai X, Yao YG, Zhang Y, Yan H, Chang S, Zhao JP, Yue WH, Luo XJ, Chen X, Xiao X, Fang Y,* Li M,* for the GeseDNA Research Team. Genome-wide association study in Han Chinese and trans-ancestry meta-analysis identify novel risk loci for bipolar disorder. JAMA Psychiatry 2020; in proof.

2.        Chang H,# Cai X,# Li HJ,# Liu WP, Zhao LJ, Zhang CY, Wang JY, Liu JW, Ma XL, Wang L, Yao YG, Luo XJ, Li M,* Xiao X.* Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus. Biological Psychiatry 2020; doi.org/10.1016/j.biopsych.2020.09.016

3.        Zhang C,# Xiao X,# Li T,* Li M.* Translational genomics and beyond in bipolar disorder. Molecular Psychiatry 2020; doi:10.1038/s41380-020-0782-9.

4.        Yang Z,# Zhou D,# Li H,# Cai X, Liu W, Wang L, Chang H, Li M,* Xiao X.* The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function and mushroom dendritic spine. Molecular Psychiatry 2020; 25(2):48-66.

5.        Cao X,# Liu WP,# Cheng L, Li HJ, Wu H, Liu Y, Chen C, Xiao X, Li M,* Wang GD,* Zhang YP.* Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs. Science Bulletin 2020; doi.org/10.1016/j.scib.2020.09.021.

6.        Cai X,# Yang ZH,# Li HJ, Xiao X, Li M,* Chang H.* A human-specific schizophrenia risk tandem repeat affects alternative splicing of a human-unique isoform AS3MTd2d3 and mushroom dendritic spine density. Schizophrenia Bulletin 2020; doi:10.1093/schbul/sbaa098.

7.        Li H, Zhang C, Cai X, Wang L, Luo F, Ma Y, Li M,* Xiao X.* Genome-wide association study of creativity reveals genetic overlap with psychiatric disorders, risk tolerance, and risky behaviors. Schizophrenia Bulletin 2020; 46(5):1317-1326.

8.        Li W,# Cai X,# Li HJ,# Song M,# Zhang CY, Yang Y, Zhang L, Zhao L, Liu W, Wang L, Shao M, Zhang Y, Zhang C, Cai J, Zhou DS, Li X, Hui L, Jia QF, Qu N, Zhong BL, Zhang SF, Chen J, Xia B, Li Y, Song X, Fan W, Tang W, Tang W, Tang J, Chen X, Yue W, Zhang D, Fang Y, Xiao X, Li M,* Lv L,* Chang H.* Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. Neuropsychopharmacology 2020; doi:10.1038/s41386-020-00788-4.

9.        Liu W,# Li W,# Cai X,# Yang Z,# Li H, Su X, Song M, Zhou DS, Li X, Zhang C, Shao M, Zhang L, Yang Y, Zhang Y, Zhao J, Chang H, Yao YG, Fang Y, Lv L,* Li M,* Xiao X.* Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci. Neuropsychopharmacology 2020; 45(7):1196-1206.

10.    Li HJ,# Qu N,# Hui L,# Cai X, Zhang CY, Zhong BL, Zhang SF, Chen J, Xia B, Wang L, Jia QF, Li W, Chang H, Xiao X,* Li M,* Li Y.* Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data. Translational Psychiatry 2020; 10(1):98.

11.    Zhou D, Xiao X, Li M.* The schizophrenia risk isoform ZNF804AE3E4 affects dendritic spine. Schizophrenia Research 2020; 218:324-325.

12.    Li HJ,# Su X,# Zhang L,# Zhang CY, Wang L, Li W, Yang Y, Lv L, Li M,* Xiao X.* Transcriptomic analyses of humans and mice provide insights into depression. Zoological Research 2020; doi:10.24272/j.issn.2095-8137.2020.174.

13.    Yang ZH,# Cai X,# Qu N,# Zhao LJ, Zhong BL, Zhang SF, Chen J, Xia B, Jiang HY, Zhou DY, Liu WP, Chang H, Xiao X, Li Y,* Li M.* Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32. Zoological Research 2020; 41(1):84-89.

14.    Hu Z,* Xiao X, Zhang Z, Li M.* Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders. Molecular Psychiatry 2019; 24(10):1400-1414.

15.    Li H,# Chang H,# Song X,# Liu W, Li L, Wang L, Yang Y, Zhang L, Li W, Zhang Y, Zhou DS, Li X, Zhang C, Fang Y, Sun Y, Dai JP, Luo XJ, Yao YG, Xiao X,* Lv L,* Li M.* Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. Neuropsychopharmacology 2019; 44(9):1552-1561.

16.    Liu W,# Yan H,# Zhou D,# Cai X,# Zhang Y, Li S, Li H, Li S, Zhou DS, Li X, Zhang C, Sun Y, Dai JP, Zhong J, Yao YG, Luo XJ, Fang Y, Zhang D, Ma Y, Yue W,* Li M,* Xiao X.* The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population. Translational Psychiatry 2019; 9(1):333.

17.    Li H,# Zhou DS,# Chang H,# Wang L, Liu W, Dai SX, Zhang C, Cai J, Liu W, Li X, Fan W, Tang W, Tang W, Liu F, He Y, Bai Y, Hu Z, Xiao X, Gao L,* Li M.* Interactome analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of bipolar disorder. Journal of Psychiatric Research 2019; 115:165-175.

18.    Xiao X, Zhang C,* Grigoroiu-Serbanescu M,* Wang L, Li L, Zhou D, Yuan T-F, Wang C, Chang H, Wu Y, Li Y, Wu D-D, Yao Y-G, Li M.* The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Molecular Psychiatry 2018; 23(9):1957-1967.

19.    Chang H,# Hoshina N,# Zhang C,# Ma Y, Cao H, Wang Y, Wu DD, Bergen SE, Landén M, Hultman CM, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, N?then MM, The Swedish Bipolar Study Group, MooDS Bipolar Consortium, Walter H, Erk S, Heinz A, Amin N, van Duijn CM, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T,* Rietschel M,* Li M.* The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders. Molecular Psychiatry 2018; 23(2):400-412.

20.    Xiao X,# Zheng F,# Chang H, Ma Y, Yao YG, Luo XJ, Li M.* The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder. Neuropsychopharmacology 2018; 43(5):1128-1137.

21.    Zhao L,# Chang H,# Zhou DS,# Cai J, Fan W, Tang W, Tang W, Li X, Liu W, Liu F, He Y, Bai Y, Sun Y, Dai J, Li L, Xiao X,* Zhang C,* Li M.* Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. Translational Psychiatry 2018; 8(1):270.

22.    Chang H,# Xiao X,# Li M.* The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. Molecular Psychiatry 2017; 22(7):944-953.

23.    Xiao X, Wang L, Wang C, Yuan TF, Zhou D, Zheng F, Li L, Grigoroiu-Serbanescu M, Ikeda M, Iwata N, Takahashi A, Kamatani Y, Kubo M, Preisig M, Kutalik Z, Castelao E, Pistis G, Amin N, van Duijn CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, N?then MM, Chang H, Luo XJ, Fang Y, Yao YG, Zhang C, Rietschel M, Li M;* Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. Translational Psychiatry 2017; 7(12):1273.

24.    Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR.* A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia associated locus. Nature Medicine 2016; 22(6):649-656.

25.    Li M,* Chang H, Xiao X. BDNF Val66Met polymorphism and bipolar disorder in European populations: a risk association in case-control, family-based and GWAS studies. Neuroscience and Biobehavioral Reviews 2016; 68:218-233.

26.    Li M,#,* Wu DD,# Yao YG, Huo YX, Liu JW, Su B, Chasman DI, Chu AY, Huang T, Qi L, Zheng Y, CHARGE Nutrition Working Group, DietGen Consortium, Luo XJ.#,* Recent positive selection drives the expansion of a schizophrenia risk non-synonymous variant at SLC39A8 in Europeans. Schizophrenia Bulletin 2016; 42(1):178-190.

27.    Li M,#,* Luo XJ,# Landén M, Bergen SE, Hultman CM, Li X, Zhang W, Yao YG, Zhang C, Liu J, Mattheisen M, Cichon S. Mühleisen TW, Degenhardt FA, N?then MM, Schulze TG, Grigoroiu-Serbanescu M, Li H, Fuller CK, Chen C, Dong Q, Chen C, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Preisig M, Kutalik Z, Castelao E, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, MooDS Consortium, The Swedish Bipolar Study Group, Rietschel M, Liu C, Kleinman JE, Hyde TM, Weinberger DR, Su B.* Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance. British Journal of Psychiatry 2016; 208(2):128-137.

28.    Li M,# Luo XJ,# Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, N?then MM, Schulze TG, Sullivan PF, Bergen SE, Donohoe G, Morris DW, Hargreaves A, Gill M, Corvin A, Hultman C, Toga AW, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis JC, Ikram MA, Fornage M, Debette S, Launer LJ, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein JL, Medland SE, Vasquez AA, Hibar DP, Franke B, Martin NG, Wright MJ, MooDS Bipolar Consortium, The Swedish Bipolar Study Group, Alzheimer’ s Disease Neuroimaging Initiative, ENIGMA consortium, CHARGE consortium, Su B.* Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry 2014; 19(4):452-461.

29.    Li M, Ge T, Feng J, Su B.* SLC6A15 rs1545843 and depression: implications from brain imaging data. American Journal of Psychiatry 2013; 170(7):805.

30.    Li M, Luo XJ, Xiao X, Shi L, Liu XY, Yin LD, Diao HB, Su B.* Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia. American Journal of Psychiatry 2011; 168(12):1318-1325.

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