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Principal Investigator
Jia-Li Li   Ph.D.  
Title Principal Investigator
Phone +86 871 65197043
Address Kunming Institute of Zoology, Chinese Academy of Sciences,No.32 Jiaochang Donglu,Kunming,Yunnan,P.R.China
Zip Code 650223
   Education and Appointments:

2000-2003 Ph.D., Fudan University  

2004-2007 Postdoctoral fellow, Mount Sinai School of Medicine  

2007-2010 Research Associate, Rutgers, the State University of New Jersey 

2010-2014 Research Assistant Professor, Rutgers, the State University of New Jersey  

2014-present, Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences 

  Professional Services
   Research Interests:

Our laboratory’s research interests focus on the mechanisms of degenerative process in neurodegenerative diseases. Among the laboratory’s accomplishments and ongoing activities are (i) epigenetic basis in neurodegeneration of Ataxia-Telangiectasia, (ii) the role of DNA demethyaltion in neuronal DNA damage response, (iii) epigenetic basis in neurodegeneration of Alzheimer’s Disorder, (iv) epigenetic basis in neurodegeneration of Dopaminergic neurons. Besides, authenticate and screen the small molecule compound, remedying the specific epigenetic regulatory system change, which for the future clinical diagnosis and preventive treatment to provide theoretical and experimental basis is also one of our major research interest. 

  Supported Projects:

Chinese Academy Sciences  

National Natural Science Foundation of China  

National Key Basic Research Program of China  

  Public Services:
  Selected Publications:

1.   Xu K, Zhang Y, and Li J*. (2021) Expression and function of circular RNAs in the mammalian brain. Cell. Mol. Life Sci. 08 February 2021. doi:10.1007/s00018-021-03780-3.

2.   Zhang Y, Zhang Z, Li L, Xu K, Ma Z, Chow H, Herrup K, and Li J*(2020) Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease. FASEB J. 00:119.

3.   Cao D, Jiang D, Zhou D, Yu H*, Li J*. (2020) A Comparative Study on 5hmC Targeting Regulation of Neurons in AD Mice by Several Natural Compound. Biomed Research International.

4.   Xu K, Zhang Y, Xiong W, Zhang Z, Wang Z, Lv L, Liu C, Hu Z, Zheng Y, Lu L, Hu X, Li J*. (2020) CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis. Nat Commun 11, 3594, doi:10.1038/s41467-020-17435-7.

5.   Chen N, Yang H, Zhong K and Li J*. (2020) Preliminary study on fine structures of subcortical nuclei in rhesus monkeys by ex vivo 9.4 T MRI. Zool Res, 1-4, doi:10.24272/j.issn.2095-8137.2020.013.

6.   Xu K, Chen D, Wang Z, Ma J, Zhou J, Chen N, Lv L, Zheng Y, Hu X, Zhang Y, Li J*. (2018) Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging. Cell Disc. 4: 48.

7.   Liu S, Wang Z, Chen D, Zhang B, Tian R, Wu J, Zhang Y, Xu K, Yang L, Cheng C, Ma J, Lv L, Zheng Y, Hu X, Zhang Y, Wang X, and Li J*. (2017) Annotation and cluster analysis of spatiotemporal- and sex-related lncRNAexpression in Rhesus Macaque brain. Geno. Res, 27(9):1608-1620.

8.   Wei S, Hua H, Chen Q, Zhang Y, Chen F, Li S, Li F, and Li J*. (2017) Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging. Zool. Res., 38(2):96-102.

9.   Jiang D, Wei S, Chen F, Zhang Y, Li J*. (2017) TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response. EMBO Rep..18(5):781-796.

10. Jiang D, Zhang Y, Hart R P, Chen J, Herrup K. and Li J*. (2015) Alteration in 5hmC-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM-deficiency. Brain. 138:3520-36.

11. Li J* and Jiang D. (2015) The role of epigenomics in the neurodegeneration of ataxia-telangiectasia. Epigenomics. 7(2):137-41.

12Li J*, Hart RP, Elyse M. Mallimo, Swerdel M, Kusnecov A and Herrup K*. (2013) EZH2-mediated histone methylation mediates neurodegeneration in ataxia-telangiectasia. Nat. Neurosci. 16(12):1745-53.

13. Herrup K, Chen J, and Li J*. (2013) Breaking news: thinking may be bad for DNA. Nat. Neurosci. 16(5):518-9.

14. Li J, Chen J, Ricupero C, Hart RP, Schwartz MS, Kusnecov A and Herrup K. (2012) Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia. Nat. Med., 18, 783790.

15. Li J*, Chen J, Vinters H, Gatti R & Herrup K. (2011) Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci. 31(20):7568-77.

16. Li J, Han Y, Plummer M and Herrup K. (2009) Cytoplasmic ATM in Neurons Modulates synaptic function. Curr. Biol. 19(24):2091-6.

  Research Team:

Laboratory Staff: 

Ms. Ying Zhang, Technician,  

Ms. Jie Xiao, Technician, 

Graduate Students:  

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