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Principal Investigator
Jia-Li Li   Ph.D.  
Title Principal Investigator
Phone +86 871 65197043
Fax
E-mail lijiali@mail.kiz.ac.cn
Address Kunming Institute of Zoology, Chinese Academy of Sciences,No.32 Jiaochang Donglu,Kunming,Yunnan,P.R.China
Zip Code 650223
 
   Education and Appointments:

2000-2003 Ph.D., Fudan University  

2004-2007 Postdoctoral fellow, Mount Sinai School of Medicine  

2007-2010 Research Associate, Rutgers, the State University of New Jersey 

2010-2014 Research Assistant Professor, Rutgers, the State University of New Jersey  

2014-present, Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences 

  Professional Services
   Research Interests:

Our laboratory’s research interests focus on the mechanisms of degenerative process in neurodegenerative diseases. Among the laboratory’s accomplishments and ongoing activities are (i) epigenetic basis in neurodegeneration of Ataxia-Telangiectasia, (ii) the role of DNA demethyaltion in neuronal DNA damage response, (iii) epigenetic basis in neurodegeneration of Alzheimer’s Disorder, (iv) epigenetic basis in neurodegeneration of Dopaminergic neurons. Besides, authenticate and screen the small molecule compound, remedying the specific epigenetic regulatory system change, which for the future clinical diagnosis and preventive treatment to provide theoretical and experimental basis is also one of our major research interest. 

  Supported Projects:

Chinese Academy Sciences  

National Natural Science Foundation of China  

National Key Basic Research Program of China  

  Public Services:
  Honors:
  Selected Publications:

1. Liu S, Wang Z, Chen D, Zhang B, Tian R, Wu J, Zhang Y, Xu K, Yang L, Cheng C, Ma J, Lv L, Zheng Y, Hu X, Zhang Y, Wang X and Li J*. Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain. Genome Research. 2017 (*corresponding author).

2. Jiang D, Wei S, Chen F, Zhang Y, Li J*. TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response. EMBO Rep. 2017, pii: e201643179 (*corresponding author).

3. Wei S, Hua H, Chen Q, Zhang Y, Chen F, Li S, Li F, Li J*. Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging. Zoological Research.  2017; 38 (2): 96-102 (*corresponding author)..

4. Jiang D, Zhang Y, Hart R P, Chen J, Herrup K, Li J*. Alteration in 5hmC-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM-deficiency. Brain. 2015 (*corresponding author).

 

5. Li J, Jiang D. The role of epigenomics in the neurodegeneration of ataxia-telangiectasia. Epigenomics. 2015; 7(2): 137-41.

 

6. Li J*, Hart R P, Elyse M. Mallimo, Swerdel M, Kusnecov A and Herrup K. EZH2-mediated histone methylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci. 2013; 16(12): 1745-53(*corresponding author).

 

7. Yang Y, Hui C-W, Li J and Herrup K.The interaction of the Atm genotype with inflammation and oxidative stress.PLoS One. 2014; 9(1): e85863.

 

8. Herrup K, Li J, Chen J and Plummer M. Ataxia-telangiectasia and the biology of ATM. The 2nd edition of book “Movement Disorders: Genetics and Models”. 2014.

 

9. Herrup K, Chen J, Li J*. Breaking news: thinking may be bad for DNA. Nat Neurosci. 2013; 16(5): 518-9(*corresponding author).

 

10. Herrup K, Li J and Chen J. The role of ATM and DNA damage in neurons: upstream and downstream connections. DNA Repair (Amst). 2013; 12(8):600.

 

11. Davila JL, Goff LA, Ricupero CL, Camarillo C, Oni EN, Swerdel M, Toro-Ramos AJ, Li J and Hart RP.A positive feedback mechanism that regulates expression of miR-9 during neurogenesis.PLoS One. 2014;9(4):e94348.

 

12. Li J, Chen J, Ricupero C, Hart RP, Schwartz MS, Kusnecov A and Herrup K. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia. Nat Med. 2012;Volume:18,Pages:783–790.

 

13. Li J*, Chen J, Vinters H, Gatti R &Herrup K. Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci. 2011; 31(20):7568-77(*corresponding author).

 

14. Li J, Han Y, Plummer M and Herrup K. Cytoplasmic ATM in Neurons Modulates synaptic function. Curr Biol. 2009; 19(24):2091-6.

  Research Team:

Laboratory Staff: 

Ms. Ying Zhang, Technician, zhangying@mail.kiz.ac.cn  

Ms. Jie Xiao, Technician, xiaojie@mail.kiz.ac.cn 

Graduate Students:  

 
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