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Principal Investigator
Bao-Wei Jiao   Ph.D.  
Title Professor
Phone +86 871 65191706
Fax
E-mail jiaobaowei@mail.kiz.ac.cn
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Zip Code 650223
 
   Education and Appointments:

Principal Investigator, joined Kunming Institute of Zoology, Chinese Academy of Sciences since July of 2013. His research team is mainly interested in regulating mammary gland stem cells by imprinted genes and long non-coding RNA (lncRNA). The mechanisms and evolutionary significance of X chromosome inactivation (XCI) in development and evolution are his research focus.

  4/2013 now  Principal investigator of Imprinting in Development and Evolution Group, Kunming Institute of Zoology, Chinese Academy of Sciences 

  10/2008 - 4/2013 Postdoctor in University of Massachusetts Medical School 

  5/2007 - 10/2008 Research Assistant in College of Traditional Chinese Medicine, The Chinese University of Hong Kong 

  9/2003 - 3/2007 Doctor of Philosophy in Environmental Science, The Chinese University of Hong Kong 

  9/2000 - 7/2003  Master of zoology, College of Life Sciences, Southwest University

  9/1996 - 7/2000 Bachelor, College of Life Sciences, Southwest University 

  Professional Services
 
   Research Interests:

1. The impact of imprinted genes on breast development 

Genomic imprinting is an epigenetic phenomenon by which certain genes can be expressed in a parent-of-origin-specific manner. Researches show that imprinted genes play important roles in early embryonic development, adult tissues development, certain genetic diseases and tumors. We will characterize functions of imprinted genes through approaches of DNA methylome, transcript some analysis and functional procedures in mice and other animals.     

2. The working models of lncRNA in breast development 

lncRNA is an RNA molecule longer than 200 nucleotides and not translated into a protein. The mechanisms of lncRNAs have been proposed in a range of developmental processes and diseases, but knowledge of the mechanisms by which they act is still surprisingly limited. We will explore this field through comprehensive discussion of the roles of these lncRNAs in mammary gland development.     

3. The roles of XCI in mammary gland development 

Recently, more and more evidence show that the mammary gland lactation is greatly regulated by epigenetic modification, such as transgenerational inheritance, which is closely linked to another important epigenetic mechanism—XCI in our previous publications. We will focus on analyzing the impacts of XCI in breast and other nutrients organs through analyzing the function of XCI in adult and embryonic tissues by studying the XCI status of breast and placenta in mouse and other model organism. This approach will also offer more comprehensive understanding on sex chromosome evolution by comparing patterns of XCI among different animals, such as tree shrews and macaques, in order to reveal the law of the evolution on X chromosome. 

  Supported Projects:

Thousand Youth Talents Plan—the Organization Department of the Central Committee of the CPC, 3 million, 2013 

Research start-up fund by Kunming Institute of Zoology, Chinese Academy of Sciences, 1.5 million, 2013 

General Programs of National Natural Science Foundation Item,1.1 million, 2013
  Public Services:
  Honors:
 
  Selected Publications:

1. Wang S#, Ke H#, Zhang H, Ma Y, Ao L, Zou L, Yang Q, Zhu H, Nie J*, Wu C*, Jiao B*. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death and Disease. 2018 Jul 24;9(8):805. 

2. Chen W#, Wang H#, Cheng M#, Ni L, Zou L, Yang Q, Cai X*, Jiao B*. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Biomedicine & Pharmacotherapy. 2018 Jul;103:435-442

3. Ke H#, Zhao L#, Zhang H#, Feng X, Xu H, Hao J, Wang S, Yang Q, Zou L, Su X, Wang L, Wu C, Wang Y, Nie J, Jiao B*. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3.Proceedings of the National Academy of Sciences of U S A. http://www.pnas.org/content/early/2018/03/21/1714573115 

4. Zhang H#, Yang X#, Feng X, Xu H, Yang Q, Zou L, Yan M, Liu D, Su X, Jiao B*. Chromosome-wide gene dosage rebalance may benefit tumor progression. Molecular Genetics and Genomics. 2018 Mar 15. https://link.springer.com/article/10.1007/s00438-018-1429-2

5. Lv C, Li F, Li X, Tian Y, Zhang Y, Sheng X, Song Y, Meng Q, Yuan S, Luan L, Andl T, Feng X, Jiao B, Xu M, Plikus MV, Dai X, Lengner C, Cui W, Ren F, Shuai J, Millar SE, Yu Z*. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications. 2017, 8(1):1036. doi: 10.1038/s41467-017-01059-5.

6. Yang X#, Wang H*, Jiao B*. Mammary gland stem cells and their application in breast cancer. Oncotarget. 2017;8(6):10675-91.

7. Ke H#, Zhao L#, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L, Jiao B*. NEAT1 is required for survival of breast cancer cells through FUS and miR-548. Gene Regulation and Systems Biology,2016,10(Suppl 1):11-7.

8. Wu Y#, Feng X#, Gao L*Jiao B*. Imprinted genes: important regulators in development.Hereditas(Beijing). 2016,38(6):508-522.

9. Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones S, Mager JBach I*. 2013.  Rnf12/RLIM is dispensable for X chromosome inactivation in the mouse embryonic epiblast. Nature2014,511(7507):86-9.  

10. Jiao B#, Taniguchi-Ishigaki N#, Güngr C#, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA#*, Bach I*. 2013. Nucleo-cytoplasmic shuttling regulates functional activity of Rnf12/RLIM. Molecular Biology of the Cell, 24(19):3085-96.

11. Jiao B, Ma H, Shokhirev M, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach Ihttp://10.20.40.10/wcm/app/editor/editor/images/spacer.gif*. 2012. http://10.20.40.10/wcm/app/editor/editor/images/spacer.gifPaternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell, 149:630-41.

12. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I*. 2010.  http://10.20.40.10/wcm/app/editor/editor/images/spacer.gifMaternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature, 467:977-81.   

13. Lin ZX*, Jiao B, Che CT, Zuo Z, Mok CF, Zhao M, Ho WK, Tse WP, Lam KY, Fan RQ, Yang ZJ, Cheng CH*. 2010. Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment. Phytotherapy Research, 24:1056-64.  

14. Jiao B, Yeung EKC, Chan CB, Cheng CHK*. 2008. Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green. Journal of Cellular Biochemistry,105:1399-409.   

15. Jiao B, Cheng CHK*. 2010. Disrupting actions of bisphenol A and malachite green on growth hormone receptor gene expression and signal transduction in seabream. Fish Physiology and Biochemistry, 36:251-61.

16. Wang DS#*, Jiao B#, Hu C, Huang X, Liu Z, Cheng CHK*. 2008. Discovery of a gonad-specific IGF subtype in teleost, Biochemical and Biophysical Research Communications, 367, 336-41.   

17. Huang X#, Jiao B#, Fung KK#, Zhang Y#, Chan CB, Lin H, Wang DS, Cheng CHK*. 2007. The presence of two distinct prolactin receptors with different signal pathways and constructive expression pattern under the stimulation of steroid hormones in teleost. Journal of Endocrinology, 194, 373-92.   

18. Liu Z#, Wu F#, Jiao B#, Zhang X, Hu C, Huang B, Zhou L, Huang X, Wang Z, Zhang Y, Nagahama Y, Cheng CHK*, Wang DS*. 2007. Molecular cloning of Dmrt1, Foxl2 and Cyp19 in Southern catfish and their possible roles in sex differentiation. Journal of Endocrinology, 194, 223-41.   

19. Jiao B#, Huang X#, Chan CB#, Zhang L#, Wang DS#, Cheng CHK*. 2006. The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology, 36, 23-40. 

  Research Team:

Staff: 

Qin Yang, Research Assistant  

Jia Hu, Research Assistant     

Graduate Students: 

Hao Ke, 2013 

Li-Min Zhao, 2013 

 
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