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Principal Investigator
Jian Yang   Ph.D  
Title Professor
Phone
Fax 0871-65199941
E-mail jianyang@mail.kiz.ac.cn
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Zip Code 650223
 
   Education and Appointments:
Director of ICDC
Education and Appointment:
1978.9 -1982.7  B.S., Biophysics, Peking University
1982.8 -1985.7  M.S., Neurophysiology, Shanghai Brain Research Institute
1985.12-1987.8  Visiting Scholar, Anatomy and Neurobiology, Colorado State University
1987.9- 1991.6  Ph.D., Physiology and Biophysics, Washington University in Seattle
1991.8-1993.12   Postdoctoral Fellow, Molecular and Cellular Physiology, Stanford University
1994.1-1996.12  Postdoctoral Fellow, UCSF and the Howard Hughes Medical Institute
1997.1- 2002.4  Assistant Professor, Department of Biological Sciences, Columbia University
2002.5- 2009.5   Associate Professor, Department of Biological Sciences, Columbia University
2009.6- present  Professor, Department of Biological Sciences, Columbia University
2011.7- present   PI, Kunming Institute of Zoology
  Professional Services
   Research Interests:
 

We focus on voltage-gated calcium channels (VGCCs) and transient receptor potential (TRP) channels. We use a combination of techniques including molecular biology, biochemistry, patch-clamp, X-ray crystallography and optical imaging to study the structure, function, regulation, targeting, localization and activity-dependent trafficking of VGCCs and TRP channels. Our objectives are to better understand how these ion channels work as molecular machines, how they function to control cell excitability and signaling, and how their mutations and malfunction cause human diseases. We will use state-of-the-art high-throughput screen technologies to search for natural molecules targeting VGCCs and TRP channels.

  Supported Projects:
  Public Services:
  Honors:

1997     Sloan Research Fellow

2000     McKnight Scholar Award

2001     EJLB Scholar

2004     The Established Investigator Award, American Heart Association

2012     Top Talents Program of Yunnan Province

  Selected Publications:
1. Fan, M-m., Zhang, W.K., Buraei, Z., and Yang, J. (2012). Molecular determinants of Gem inhibition of P/Q-type voltage-gated Ca2+ channels. J. Biol. Chem. In press.
2. Zhu, J.*, Yu, Y.*, Ulbrich, M.H., Li, M-h., Isacoff, E.Y., Honig, B., and Yang, J. (2011). A structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc. Natl. Acad. Sci. 108, 10133-10138.
3. Li, M-h., Yu, Y., and Yang, J. (2011). Structural biology of TRP channels. Adv. Exp. Med. Biol., 704, 1-23.
4. Buraei, Z., and Yang, J. (2010). The  subunit of voltage-gated Ca2+ channels. Physiological Reviews. 90, 1461-1506.
5. Fan, M-m.*, Buraei, Z.*, Luo, H-R., Levenson-Palmer, R., and Yang, J. (2010). Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavβ interaction. Proc. Natl. Acad. Sci. 107, 14887-14892.
6. Zhang, Y., Yamada, Y., Fan, M., Bangaru, S.D., Lin, B., and Yang, J. (2010). The β-subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6. J. Biol. Chem. 285, 2527-2536.
7. Yu, Y., Ulbrich, M.H., Li, M-h., Chen, X-Z., Ong, A.C.M., Tong, L., Isacoff, E.Y., and Yang, J. (2009). Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc. Natl. Acad. Sci. 106, 11558-11563.
8. Zhang, Y., Chen, Y-h., Bangaru, S.D., Abele, K., Tanabe, S., Kozasa, T., and Yang, J. (2008). Origin of the voltage-dependence of G protein regulation of P/Q-type Ca2+ channels. J. Neurosci. 28, 14176-14188.
9. He, L-l., Zhang, Y., Chen, Y-h., Fitzmaurice, A., and Yang, J. (2007). Functional modularity of the  subunit of voltage-gated Ca2+ channels. Biophysical Journal 93, 834-845.
10. Michailidis, Y., Zhang, Y., and Yang, J. (2007). The lipid connection - Regulation of voltage-gated Ca2+ channels by phosphoinositides. Pflugers Ach. 455, 147-155.
11. Chen, Y-h., Li, M-h., Zhang, Y.,  He., L-l., Yamada, Y., Fitzmaurice, A., Shen, Y., Zhang, H., Tong, L., and Yang, J. (2004). Structural basis of the 1 interaction of voltage-gated Ca2+ channels. Nature 429, 675-680.
12. Xiao, J., Zhen, X-G., and Yang, J. (2003). Localization of PIP2 activation gate in inward rectifier K+ channels. Nature Neurosci. 6, 811-818.
13. Wu, L.*, Bauer, C*., Zhen, X-G., Xie, C., and Yang, J. (2002). Dual regulation of voltage-gated calcium channels by PIP2. Nature 419, 947-952. 
 
  Research Team:
 
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