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Principal Investigator
Yong-Bin Chen   Ph.D  
Title Professor
Phone +86 871 65176320
Fax +86 871 65176312
E-mail ybchen@mail.kiz.ac.cn
Address Kunming Institute of Zoology, the Chinese Academy of Sciences 32 Jiaochang Donglu, Kunming, Yunnan, 650223, China
Zip Code 650223
 
   Education and Appointments:
Yong-Bin Chen, Ph.D, Professor

Tel: 86-871-5176320 ; Fax: 86-871-5176312

E-mail: ybchen@mail.kiz.ac.cn

2012.05 – Present: Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences

2010.12 – 2012.05: Instructor, UT Southwestern Medical Center at Dallas, TX, USA

2005.12 – 2010.11: Postdoctoral Fellow, UT Southwestern Medical Center at Dallas, TX, USA

2000.09 –2005.07: PhD, Shanghai Institute of Biochemistry and Cell Biology, SIBS, CAS

1996.09 –2000.07: B.S. Wuhan University

  Professional Services
   Research Interests:
The major interest of our lab is inductive signals involved in regulating tumor and stem cell. We use Drosophila, chicken, mouse, monkey and tree shrew as model systems to study the fundamental and prevalent mechanisms that control tumor and stem cells self-renew, proliferation, differentiation and so on. We are also establishing tumor models in the primate animals and developing drug screening platforms for serial cancers in the lab
  Supported Projects:
  Public Services:
  Honors:
  Selected Publications:

1.  Xu, P.F#., Jiang, L.P#., Yang, Y#., Wu, M.G., Liu ,B.Y., Shi, Y.L., Shen, Q.S., Jiang, X.L., He ,Y.M., Cheng, D,T., Xiong, Q.X., Yang, Z.Z., Duan, L.C., Lin, J., Zhao, S., Shi, P., Yang, C.P*., Chen,Y.B*.,(2020)PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.Theranostics.10(8): 3767-3778.

2. Xiong,Q.X#.,Liu,B.Y#.,Ding,M.X.,Zhou,J.M.,Yang, C.P*., Chen,Y.B*.,(2020)Hypoxia and cancer related pathology.Cancer Letters. 486 : 17

3. Shi, Y.L#., Fan,S.Q#., Wu,M.G#., Zuo,Z.X., Li, X.Y., Jiang, L.P., Shen, Q.S., Xu, P.F., Zeng, L., Zhou, Y.C., Huang, Y.C., Yang, Z.Z., Zhou, J.M., Gao, J., Zhou, H., Xu, S.H., Ji, H.B., Shi, P., Wu, D.D*., Yang, C.P*., Chen, Y.B*., (2019).YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.Nature communications10:4892

4. Wu,D.D#.*., Yang, C.P#., Wang,M.S#., Dong,K.Z#., Yan, D.W#., Hao,Z.Q#., ,Fan, S.Q., Chu ,S.Z., Shen,Q.S., Jiang,L.P., Li,Y. , Zeng,L., Liu, H.Q., Xie,H.B., Ma,Y.F. , Kong, X.Y., Yang,S.L. , Dong,X.X. , Ali Esmailizadeh Koshkoiyeh, David M Irwin, Xiao,X., Li,M., Dong,Y., Wang,W., Shi, P., Li,H.P., Ma, Y.H*., Gou,X*., Chen,Y.B*., Zhang,Y.P*., (2019)Convergent genomic signatures of high altitude adaptation among domestic mammals National Science Review doi: http://dx.doi.org/10.1101/743955.

5. Yu, L#*., Wang, G.D#., Ruan, J#., Chen, Y.B#., Yang, C.P#., Cao, X#., Wu, H#., Liu, Y.H#., Du, Z.L#., Wang, X.P#., Yang, J#., Chen, S.C#., Zhong, L., Wang, L., Wang, X., Hu, J.Y., Fang, L., Bai, B., Wang, K.L., Zhang, J.G., Yang, Y.Q., Zhang, C.L., Long, Y.C., Li, H.S., Yang, J.Y., Irwin, D., Ryder, O., Li, Y., Wu, S.F., Wu, C.I*., Zhang, Y.P*. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nature Genetics. 48(8):947-52.

6. Yang, C.P#., Li, X.Y#., Wu, Y#., Shen, Q.S#., Zeng, Y., Xiong, Q.X., Wei, M.P, Chen, C.H., Liu, J.W., Huo, Y.X., Li, K.Q., Xue, G., Yao, Y.G., Zhang, C., Li, M., Chen, Y.B*., Luo, X.J*. (2018). Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nature communications 9, 838.

7. Jiang, L.P., Fan, S.Q., Xiong, Q.X., Zhou, Y.C., Yang, Z.Z., Li, G.F., Huang, Y.C., Wu, M.G., Shen, Q.S., Liu, K., Yang, C.P*., Chen, Y.B*. (2018). GRK5 functions as an oncogenic factor in non-small-cell lung cancer. Cell death & disease 9, 295.

8. Yin, L#., Jiang, L.P#., Shen, Q.S#., Xiong, Q.X#., Zhuo, X., Zhang, L.L., Yu, H.J., Guo, X., Luo, Y., Dong, J*., Kong, Q.P*., Yang, C.P*., Chen, Y.B*. (2017). NCAPH plays important roles in human colon cancer. Cell death & disease 8, e2680.

9. Chen, Y.B*., Jiang, J*. (2013) Decoding the phosphorylation code in Hedgehog signal transduction. Cell Research 23, 186-200.

10. Yang, C.P., Chen, W.L., Chen, Y.B*., Jiang, J*. (2012) Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Research 22, 1593-1604.

 

  Research Team:

Laboratory  Staff 

Dr. Cui-Ping Yang, Associate Professorcuipingyang@mail.kiz.ac.cn 

Mr. Xing-Pin Chen, Secretarychenxingpin@mail.kiz.ac.cn 

Mr. Zhong-Liang Chen, Technician 

Ms. Xing-Gui Zhao, Technician 

Ms. Dan XuTemporary Technicianxudan_6677@163.com 

Graduate Students 

Li-Ping JiangQiu-Shuo ShenZhen-Yu HuYing-Jie Miao, Yong YangBai-Zhang Dai 

 
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